Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace

Autor: Maren Heimhalt, Alex Berndt, Jane Wagstaff, Madhanagopal Anandapadamanaban, Olga Perisic, Sarah Maslen, Stephen McLaughlin, Conny Wing-Heng Yu, Glenn R Masson, Andreas Boland, Xiaodan Ni, Keitaro Yamashita, Garib N Murshudov, Mark Skehel, Stefan M Freund, Roger L Williams

Publikováno v: eLife, Vol 10 (2021)

The mTORC1 kinase complex regulates cell growth, proliferation, and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated with some cancers, we reconstituted mTORC1 with DEPTOR to understand its function. We find t

Externí odkaz: https://doaj.org/article/f3e3156092d447fd9fa28ea08dad4816

Partial inhibition of nitric oxide synthase activity stimulates the nuclear maturation progression of bovine cumulus–oocyte complex in vitro in the presence of hemisections of the follicular walls

Autor: V. L. Maciel, M.C. Caldas-Bussiere, Wlaisa Sampaio, Carla Sobrinho Paes de Carvalho, Matheus Pedrotti de Cesaro, Márcia R Faes, Diego Fernando Dubeibe, Celia Raquel Quirino, Paulo Bayard Dias Gonçalves

Publikováno v: Zygote. 28:388-396

SummaryThis study aimed to assess the effects of the inhibition of nitric oxide synthase (NOS) on events that modulate bovine in vitro oocyte maturation. Cumulus–oocyte complexes (COCs) were cultured with hemisections (HSs) of the follicular walls

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97057e15f05e75c15040c9ca0d1e2321
https://doi.org/10.1017/s0967199420000234

Inhibition of GGPPS1 attenuated LPS-induced acute lung injury and was associated with NLRP3 inflammasome suppression

Autor: Bing Wan, Lin Wu, Jia-jia Jin, Suhua Zhu, Ping Zhan, Xiaoxia Wang, Yong Song, Tangfeng Lv, Ning-wei Zhao, Chao-jun Li, Wujian Xu, Hongbing Liu, Qian Zou

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 316:L567-L577

Inhibition of the mevalonate pathway using statins has been shown to be beneficial in the treatment of acute lung injury (ALI). Here, we investigated whether partial inhibition of this pathway by targeting geranylgeranyl pyrophosphate synthase large

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf6b866a60f67b4f57c6821cbb2dd72
https://doi.org/10.1152/ajplung.00190.2018

Glycolysis is integral to histamine‐induced endothelial hyperpermeability

Autor: Jong-Hyung Lim, Tiago C. Alves, Peter Mirtschink, George Hajishengallis, Thomas Noll, Anke Witt, Sylvia Grossklaus, Constantinos M. Mikelis, Triantafyllos Chavakis, Nikolais Androulaki, Sanaullah Sajib, Tatyana Grinenko, Michael Gerlach, Anupam Das, Eman Hagag, David Sprott, Athanasios Ziogas

Publikováno v: FASEB J

Histamine-induced vascular leakage is a core process of allergic pathologies, including anaphylaxis. Here, we show that glycolysis is integral to histamine-induced endothelial barrier disruption and hyperpermeability. Histamine rapidly enhanced glyco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b51c94e2e49c91263f93ca93dd6cfa
https://doi.org/10.1096/fj.202001634r

Comparative vulnerability of PET radioligands to partial inhibition of P-glycoprotein at the blood-brain barrier: A criterion of choice?

Autor: Sylvain Auvity, Oliver Langer, Louise Breuil, Solène Marie, Sébastien Goutal, Fabien Caillé, Wadad Saba, Nicolas Tournier, Charles Truillet

Publikováno v: Journal of Cerebral Blood Flow and Metabolism
Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, In press, pp.0271678X2110454. ⟨10.1177/0271678X211045444⟩
Journal of Cerebral Blood Flow and Metabolism, In press, pp.0271678X2110454. ⟨10.1177/0271678X211045444⟩
J Cereb Blood Flow Metab

Only partial deficiency/inhibition of P-glycoprotein (P-gp, ABCB1) function at the blood-brain barrier (BBB) is likely to occur in pathophysiological situations or drug-drug interactions. This raises questions regarding the sensitivity of available P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6380f972cc8379139da0064e7b586554
https://hal-cea.archives-ouvertes.fr/cea-03356224/document