MiR-455-5p suppresses PDZK1IP1 to promote the motility of oral squamous cell carcinoma and accelerate clinical cancer invasion by regulating partial epithelial-to-mesenchymal transition

Autor: Sheng-Yen Hsiao, Shang-Mei Weng, Jenn-Ren Hsiao, Yi-Ying Wu, Jia-En Wu, Chia-Hao Tung, Wan-Lin Shen, Shu-Fang Sun, Wen-Tsung Huang, Cheng-Yao Lin, Shang-Hung Chen, Tse-Ming Hong, Yuh-Ling Chen, Jang-Yang Chang

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-19 (2023)

Abstract Background Lymph node and distant metastasis contribute to poor outcomes in patients with oral squamous cell carcinoma (OSCC). The mechanisms regulating cancer migration and invasion play a key role in OSCC. Methods We determined migration a

Externí odkaz: https://doaj.org/article/0aac509a7647492fab204db355a88715

Long noncoding RNA MYOSLID promotes invasion and metastasis by modulating the partial epithelial-mesenchymal transition program in head and neck squamous cell carcinoma

Autor: Hong-Gang Xiong, Hao Li, Yao Xiao, Qi-Chao Yang, Lei-Lei Yang, Lei Chen, Lin-Lin Bu, Wen-Feng Zhang, Jia-Li Zhang, Zhi-Jun Sun

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)

Abstract Background Partial epithelial mesenchymal transition (p-EMT) was found to play a potential role in the initial stage of metastasis in human head and neck squamous cell carcinoma (HNSCC). Some long noncoding RNAs (lncRNAs) have been reported

Externí odkaz: https://doaj.org/article/2571833e58ee411f99704ded533c80af

Dual reporter genetic mouse models of pancreatic cancer identify an epithelial‐to‐mesenchymal transition‐independent metastasis program

Autor: Yang Chen, Valerie S LeBleu, Julienne L Carstens, Hikaru Sugimoto, Xiaofeng Zheng, Shruti Malasi, Dieter Saur, Raghu Kalluri

Publikováno v: EMBO Molecular Medicine, Vol 10, Iss 10, Pp 1-13 (2018)

Abstract Epithelial‐to‐mesenchymal transition (EMT) is a recognized eukaryotic cell differentiation program that is also observed in association with invasive tumors. Partial EMT program in carcinomas imparts cancer cells with mesenchymal‐like

Externí odkaz: https://doaj.org/article/7240628df48e479797a97ac8d277c95a

SLUG-related partial epithelial-to-mesenchymal transition is a transcriptomic prognosticator of head and neck cancer survival

Autor: Schinke, H., Pan, M., Akyol, M., Zhou, J., Shi, E., Kranz, G., Libl, D., Quadt, T., Simon, F., Canis, M., Baumeister, P., Gires, O.

Publikováno v: Molecular Oncology
Mol. Oncol., DOI: 10.1002/1878-0261.13075 (2021)

Partial epithelial‐to‐mesenchymal transition (pEMT) contributes to cellular heterogeneity that is associated with nodal metastases and unfavorable clinical parameters in head and neck squamous cell carcinomas (HNSCCs). We developed a single‐cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::47e45fe1c42cdf6cb7b35f6c39da14d5
https://pubmed.ncbi.nlm.nih.gov/34382739

SLUG-related partial epithelial-to-mesenchymal transition is a transcriptomic prognosticator of head and neck cancer survival

Autor: Akyol, Merve, Schinke, Henrik, Pan, Min, Zhou, Jiefu, Shi, Enxian, Kranz, Gisela, Libl, Darko, Quadt, Tanja, Simon, Florian, Canis, Martin, Baumeister, Philipp, Gires, Olivier, School of Medicine

Publikováno v: Molecular Oncology

Partial epithelial-to-mesenchymal transition (pEMT) contributes to cellular heterogeneity that is associated with nodal metastases and unfavorable clinical parameters in head and neck squamous cell carcinomas (HNSCCs). We developed a single-cell RNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3076::a5d8fed8df51919ceb592b3d8d877748
http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/9826