Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Parthasarathy Sampathkumar"'
Autor:
Parthasarathy Sampathkumar, Heekyung Jung, Hui Chen, Zhengjian Zhang, Nicholas Suen, Yiran Yang, Zhong Huang, Tom Lopez, Robert Benisch, Sung-Jin Lee, Jay Ye, Wen-Chen Yeh, Yang Li
Publikováno v:
eLife, Vol 13 (2024)
Molecules that facilitate targeted protein degradation (TPD) offer great promise as novel therapeutics. The human hepatic lectin asialoglycoprotein receptor (ASGR) is selectively expressed on hepatocytes. We have previously engineered an anti-ASGR1 a
Externí odkaz:
https://doaj.org/article/a9f6fd6b3417451d9b40177a6d13884a
Autor:
Anniina T. Virtanen, Teemu Haikarainen, Parthasarathy Sampathkumar, Maaria Palmroth, Sanna Liukkonen, Jianping Liu, Natalia Nekhotiaeva, Stevan R. Hubbard, Olli Silvennoinen
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 75 (2023)
Hyperactive mutation V617F in the JAK2 regulatory pseudokinase domain (JH2) is prevalent in patients with myeloproliferative neoplasms. Here, we identified novel small molecules that target JH2 of JAK2 V617F and characterized binding via biochemical
Externí odkaz:
https://doaj.org/article/6cfdba99ff324992a07f46b8c564e944
Autor:
Huy, Nguyen, Hui, Chen, Meghah, Vuppalapaty, Elizabeth, Whisler, Kelsey Ronarda, Logas, Parthasarathy, Sampathkumar, Russell Byron, Fletcher, Asmiti, Sura, Nicholas, Suen, Suhani, Gupta, Tom, Lopez, Jay, Ye, Shengjiang, Tu, Menaka, Bolaki, Wen-Chen, Yeh, Yang, Li, Sung-Jin, Lee
Publikováno v:
Translational Vision Science & Technology. 11:19
There remains a high unmet need for therapies with new mechanisms of action to achieve reperfusion of ischemic retina in diabetic retinopathy. We examined whether a novel frizzled class receptor 4 (FZD4) agonist could promote regeneration of function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ad1de27f5c99c1e91d27a01b5d7a97
https://doi.org/10.1167/tvst.11.9.19
https://doi.org/10.1167/tvst.11.9.19
Autor:
Hyun Bong, Park, Parthasarathy, Sampathkumar, Corey E, Perez, Joon Ha, Lee, Jeannie, Tran, Jeffrey B, Bonanno, Elissa A, Hallem, Steven C, Almo, Jason M, Crawford
Publikováno v:
The Journal of biological chemistry. 292(16)
Members of the gammaproteobacterial Photorhabdus genus share mutualistic relationships with Heterorhabditis nematodes, and the pairs infect a wide swath of insect larvae. Photorhabdus species produce a family of stilbenes, with two major components b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::096a52711fce42991c16f9db83a4984f
https://pubmed.ncbi.nlm.nih.gov/28246174
https://pubmed.ncbi.nlm.nih.gov/28246174
Autor:
Puneeth Puneeth, Gangarekaluve J. Naveen, Vishwanath Koti, Nitrahalli D. Prasanna, Litton Bhandari, Javaregowda Satheesh, Parthasarathy Sampathkumara
Publikováno v:
Iranian Journal of Materials Science and Engineering, Vol 19, Iss 1, Pp 1-15 (2022)
Hybrid composite finds wide application in various fields. In this present study, the hybrid composites are developed using stir casting technique as per Taguchi’s L9 orthogonal array. Hybrid composites were fabricated using Aluminium Al6082 as the
Externí odkaz:
https://doaj.org/article/bdd4accc88164b51a65487e6f66d29d3
Publikováno v:
Bioconjugate Chemistry. 15:685-693
The self-assembling proteins that form crystalline surface layers (S-layers) on many microbial species have found numerous applications due to their nanostructured nature. To devise a new method to construct surface displays that exploit S-layer self
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5b91641459a261b208cd364b9cf5c1
https://doi.org/10.1021/bc034204r
https://doi.org/10.1021/bc034204r
Autor:
Parthasarathy, Sampathkumar, Seung Joong, Kim, Danalyn, Manglicmot, Kevin T, Bain, Jeremiah, Gilmore, Tarun, Gheyi, Jeremy, Phillips, Ursula, Pieper, Javier, Fernandez-Martinez, Josef D, Franke, Tsutomu, Matsui, Hiro, Tsuruta, Shane, Atwell, Devon A, Thompson, J Spencer, Emtage, Stephen R, Wasserman, Michael P, Rout, Andrej, Sali, J Michael, Sauder, Steven C, Almo, Stephen K, Burley
Publikováno v:
Proteins, vol 80, iss 8
The nuclear pore complex (NPC), embedded in the nuclear envelope, is a large, dynamic molecular assembly that facilitates exchange of macromolecules between the nucleus and cytoplasm. The yeast NPC is an eight-fold symmetric annular structure compose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7fd2dbc1d11453a60ce258a631e022fa
https://escholarship.org/uc/item/85c5q7k1
https://escholarship.org/uc/item/85c5q7k1
Autor:
Parthasarathy, Sampathkumar, Frances, Lu, Xun, Zhao, Zhenzhen, Li, Jeremiah, Gilmore, Kevin, Bain, Marc E, Rutter, Tarun, Gheyi, Kenneth D, Schwinn, Jeffrey B, Bonanno, Ursula, Pieper, J Eduardo, Fajardo, Andras, Fiser, Steven C, Almo, Subramanyam, Swaminathan, Mark R, Chance, David, Baker, Shane, Atwell, Devon A, Thompson, J Spencer, Emtage, Stephen R, Wasserman, Andrej, Sali, J Michael, Sauder, Stephen K, Burley
Publikováno v:
Proteins. 78(14)
The X-ray structure of a putative BenF-like (gene name: PFL1329) protein from Pseudomonas fluorescens Pf-5 (PflBenF) has been determined at 2.6Å resolution. X-ray crystallography revealed a canonical 18-stranded β-barrel fold that forms a central p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cdeba8396d9107e39da0598726c488c4
https://pubmed.ncbi.nlm.nih.gov/20737437
https://pubmed.ncbi.nlm.nih.gov/20737437
Autor:
Parthasarathy, Sampathkumar, Tarun, Gheyi, Stacy A, Miller, Kevin T, Bain, Mark, Dickey, Jeffrey B, Bonanno, Seung Joong, Kim, Jeremy, Phillips, Ursula, Pieper, Javier, Fernandez-Martinez, Josef D, Franke, Anne, Martel, Hiro, Tsuruta, Shane, Atwell, Devon A, Thompson, J Spencer, Emtage, Stephen R, Wasserman, Michael P, Rout, Andrej, Sali, J Michael, Sauder, Stephen K, Burley
Publikováno v:
Proteins. 79(5)
Nuclear pore complexes (NPCs), responsible for the nucleo-cytoplasmic exchange of proteins and nucleic acids, are dynamic macromolecular assemblies forming an eight-fold symmetric co-axial ring structure. Yeast (Saccharomyces cerevisiae) NPCs are mad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::300edc25b30d044dce00ab4d7e33c6ea
https://pubmed.ncbi.nlm.nih.gov/21365675
https://pubmed.ncbi.nlm.nih.gov/21365675
Autor:
Parthasarathy, Sampathkumar, Sinem A, Ozyurt, Johnny, Do, Kevin T, Bain, Mark, Dickey, Logan A, Rodgers, Tarun, Gheyi, Andrej, Sali, Seung Joong, Kim, Jeremy, Phillips, Ursula, Pieper, Javier, Fernandez-Martinez, Josef D, Franke, Anne, Martel, Hiro, Tsuruta, Shane, Atwell, Devon A, Thompson, J Spencer, Emtage, Stephen R, Wasserman, Michael P, Rout, J Michael, Sauder, Stephen K, Burley
Publikováno v:
Proteins. 78(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0055d872e8a82abed77c8735cf342585
https://pubmed.ncbi.nlm.nih.gov/20310066
https://pubmed.ncbi.nlm.nih.gov/20310066