Výsledky vyhledávání - "Partha S. Mitra"

PCB exposure and potential future cancer incidence in Slovak children: an assessment from molecular finger printing by Ingenuity Pathway Analysis (IPA®) derived from experimental and epidemiological investigations

Autor: Kepher H. Makambi, Lubica Palkovicova Murinova, Christopher A. Loffredo, Eric P. Hoffman, Somiranjan Ghosh, Partha S. Mitra, Tomas Trnovec, Eva Sovcikova, Sisir K. Dutta

Publikováno v: Environmental Science and Pollution Research. 25:16493-16507

The risk of cancer due to PCB exposure in humans is highly debated. In eastern Slovakia, high exposure of the population to organochlorines (especially PCBs) was associated with various disease and disorder pathways, viz., endocrine disruption, metab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076a3b55c409aff8d2ab487b09365d67
https://doi.org/10.1007/s11356-017-0149-1

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Differential gene expression and a functional analysis of PCB-exposed children: Understanding disease and disorder development

Autor: Eva Sovcikova, Partha S. Mitra, Shizhu Zang, Svetlana Ghimbovschi, Eric P. Hoffman, Dean Sonneborn, Somiranjan Ghosh, Sisir K. Dutta, Irva Hertz-Picciotto, Lubica Palkovicova, Tomas Trnovec

Publikováno v: Environment International, Vol 40, Iss, Pp 143-154 (2012)

The goal of the present study is to understand the probable molecular mechanism of toxicities and the associated pathways related to observed pathophysiology in high PCB-exposed populations. We have performed a microarray-based differential gene expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b450f25bde4976cfba9ca2d26fd4bacc
http://www.sciencedirect.com/science/article/pii/S0160412011001942

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Analysis of the toxicogenomic effects of exposure to persistent organic pollutants (POPs) in Slovakian girls: Correlations between gene expression and disease risk

Autor: Shizhu Zang, Dean Sonneborn, Lubica Palkovicova, Eva Sovcikova, Irva Hertz-Picciotto, Tomas Trnovec, Svetlana Ghimbovschi, Somiranjan Ghosh, Eric P. Hoffman, Partha S. Mitra, Sisir K. Dutta

Publikováno v: Environment International, Vol 39, Iss 1, Pp 188-199 (2012)

The chemical composition of persistent organic pollutants (POPs) in the environment is not uniform throughout the world, and these contaminants contain many structurally different lipophilic compounds. In a well-defined study cohort in the Slovak Rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde0f2e8ac0fc7ebe8842db12449669a
http://www.sciencedirect.com/science/article/pii/S0160412011002285

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Global gene expression and Ingenuity biological functions analysis on PCBs 153 and 138 induced human PBMC in vitro reveals differential mode(s) of action in developing toxicities

Autor: Sisir K. Dutta, Eric P. Hoffman, Somiranjan Ghosh, Svetlana Ghimbovschi, Partha S. Mitra, Shizhu Zang

Publikováno v: Environment International, Vol 37, Iss 5, Pp 838-857 (2011)

Several reports have indicated that low level of polychlorinated biphenyl (PCB) exposure can adversely affect a multitude of physiological disorders and diseases in in vitro, in vivo, and as reported in epidemiological studies. This investigation is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e36aecc2e2031e8a77e8241aa063c10
http://www.sciencedirect.com/science/article/pii/S0160412011000419

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Regulated Phosphorylation of a Major UDP-glucuronosyltransferase Isozyme by Tyrosine Kinases Dictates Endogenous Substrate Selection for Detoxification*

Autor: Partha S. Mitra, Sunit K. Chakraborty, Nikhil K. Basu, Ida S. Owens, Tapas Saha, Mousumi Basu

Publikováno v: The Journal of Biological Chemistry

Whereas UDP-glucuronosyltransferase-2B7 is widely distributed in different tissues, it preferentially detoxifies genotoxic 4-OH-estradiol and 4-OH-estrone (4-OHE(1)) with barely detectable 17β-estradiol (E(2)) conversion following expression in COS-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02dfcd1ecbaa88ba34e73540b707930
http://europepmc.org/articles/PMC3020772

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The Major Chemical-detoxifying System of UDP-glucuronosyltransferases Requires Regulated Phosphorylation Supported by Protein Kinase C

Autor: Mousumi Basu, Nikhil K. Basu, Labanyamoy Kole, Ida S. Owens, Partha S. Mitra, Kushal Chakraborty

Publikováno v: Journal of Biological Chemistry. 283:23048-23061

Finding rapid, reversible down-regulation of human UDP-glucuronosyltransferases (UGTs) in LS180 cells following curcumin treatment led to the discovery that UGTs require phosphorylation. UGTs, distributed primarily in liver, kidney, and gastrointesti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c261572e67f18dba945a5b89ba05bdf
https://doi.org/10.1074/jbc.m800032200

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Targeting Base Excision Repair for Chemosensitization

Autor: Jerita J. Dubash, Rabindra Roy, Sanjay Adhikari, Partha S. Mitra, Sujata Choudhury, Shyama Prasad Sajankila

Publikováno v: Anti-Cancer Agents in Medicinal Chemistry. 8:351-357

In both bacteria and eukaryotes the alkylated, oxidized, and deaminated bases and depurinated lesions are primarily repaired via an endogenous preventive pathway, i.e. base excision repair (BER). Radiation therapy and chemotherapy are two important m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e810ad859f7b3b37cc3bc09425313de
https://doi.org/10.2174/187152008784220366

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Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity

Autor: Nikhil K. Basu, Ida S. Owens, Amanda E Garza, Rajat Banerjee, Tapas Saha, Shigeki Kubota, Martina Kovarova, Partha S. Mitra, Juan Rivera

Publikováno v: Proceedings of the National Academy of Sciences. 102:6285-6290

UDP-glucuronosyltransferase (UGT) isozymes catalyze detoxification of numerous chemical toxins present in our daily diet and environment by conjugation to glucuronic acid. The special properties and enzymatic mechanism(s) that enable endoplasmic reti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5241690bd94b5a2ea1a9544da13699d6
https://doi.org/10.1073/pnas.0407872102

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Snake Venom Hemorrhagins

Autor: Subhadeep Sarker, Kunal Kumar Bhattacharyya, Rathanath Hati, Partha S. Mitra

Publikováno v: Critical Reviews in Toxicology. 29:1-19

Viperine and crotaline snake venoms contain one or more hemorrhagic principles called hemorrhagins. These are zinc-containing metalloproteases characterized by the presence of a protease domain, with additional domains in some of them. They act essen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb1645b69ae8ac0a86d6cae9ede1eb5
https://doi.org/10.1080/10408449991349168

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