Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Parth H. Amin"'
2
Akademický článek
Toxoplasma gondii Co-opts the Unfolded Protein Response To Enhance Migration and Dissemination of Infected Host Cells
Autor: Leonardo Augusto, Jennifer Martynowicz, Parth H. Amin, Nada S. Alakhras, Mark H. Kaplan, Ronald C. Wek, William J. Sullivan
Publikováno v: mBio, Vol 11, Iss 4 (2020)
ABSTRACT Toxoplasma gondii is an intracellular parasite that reconfigures its host cell to promote pathogenesis. One consequence of Toxoplasma parasitism is increased migratory activity of host cells, which facilitates dissemination. Here, we show th
Externí odkaz: https://doaj.org/article/3d630c390fc84de5b6a66b41628efa5f
Zobrazit plný text záznamu
3
GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
Autor: Ricardo A. Cordova, Jagannath Misra, Parth H. Amin, Angela J. Klunk, Nur P. Damayanti, Kenneth R. Carlson, Andrew J. Elmendorf, Hyeong-Geug Kim, Emily T. Mirek, Bennet D. Elzey, Marcus J. Miller, X. Charlie Dong, Liang Cheng, Tracy G. Anthony, Roberto Pili, Ronald C. Wek, Kirk A. Staschke
Publikováno v: eLife. 11
A stress adaptation pathway termed the integrated stress response has been suggested to be active in many cancers including prostate cancer (PCa). Here, we demonstrate that the eIF2 kinase GCN2 is required for sustained growth in androgen-sensitive a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8cbbbe26b5658cae631cca4cd553e1
https://pubmed.ncbi.nlm.nih.gov/36107759
Zobrazit plný text záznamu
5
An RNA stem-loop functions in conjunction with an upstream open reading frame to direct preferential translation in the integrated stress response
Autor: Parth H. Amin, Kenneth R. Carlson, Ronald C. Wek
Publikováno v: Journal of Biological Chemistry. 299:102864
In response to environmental stresses, cells invoke translational control to conserve resources and rapidly reprogram gene expression for optimal adaptation. A central mechanism for translational control involves phosphorylation of the α subunit of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a9ec335fbde18865a024589132e52c
https://doi.org/10.1016/j.jbc.2022.102864
Zobrazit plný text záznamu
6
Abstract 3040: The eIF2 kinase GCN2 controls expression of key amino acid transporters and is critical for prostate cancer growth and progression
Autor: Ricardo Cordova, Jagannath Misra, Nur P. Damayanti, Parth H. Amin, Kenneth R. Carlson, Angela J. Klunk, Emily T. Mirek, Marcus J. Miller, Tracy G. Anthony, Roberto Pili, Ronald C. Wek, Kirk A. Staschke
Publikováno v: Cancer Research. 82:3040-3040
The Integrated Stress Response (ISR) is central for adaptation and survival of tumor cells in response to exogenous and endogenous stresses. The ISR features a family of protein kinases that phosphorylate the eukaryotic translation initiation factor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::973b5e1ab20c42078740bada5cb0a7d8
https://doi.org/10.1158/1538-7445.am2022-3040
Zobrazit plný text záznamu
7
Akademický článek
Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii.
Autor: Leonardo Augusto, Parth H Amin, Ronald C Wek, William J Sullivan
Publikováno v: PLoS Pathogens, Vol 15, Iss 6, p e1007746 (2019)
Toxoplasma gondii is a prevalent protozoan parasite that can infect any nucleated cell but cannot replicate outside of its host cell. Toxoplasma is auxotrophic for several nutrients including arginine, tryptophan, and purines, which it must acquire f
Externí odkaz: https://doaj.org/article/6a529d6eedf84a8284c70024423e30bb
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje