Clinical tolerance but no protective efficacy in a placebo-controlled trial of repeated controlled schistosome infection.

Autor: Koopman JPR; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands., Houlder EL; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands., Janse JJ; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands., Lamers OA; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands., Roozen GV; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands., Sijtsma JC; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands., Casacuberta-Partal M; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands., Hilt ST; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands., van der Stoep MYEC; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands., van Amerongen-Westra IM; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands., Brienen EA; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands., Wammes LJ; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands., van Lieshout L; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands., van Dam GJ; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands., Corstjens PL; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands., van Diepen A; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands., Yazdanbakhsh M; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands., Hokke CH; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands., Roestenberg M; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Dec 12. Date of Electronic Publication: 2024 Dec 12.

Safety and infectivity of female cercariae in Schistosoma-naïve, healthy participants: a controlled human Schistosoma mansoni infection study.

Autor: Koopman JPR; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Houlder EL; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Janse JJ; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Casacuberta-Partal M; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Lamers OAC; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Sijtsma JC; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., de Dood C; Department of Cell and Chemical Biology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Hilt ST; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands; Department of Cell and Chemical Biology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Ozir-Fazalalikhan A; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Kuiper VP; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Roozen GVT; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., de Bes-Roeleveld LM; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Kruize YCM; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Wammes LJ; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Smits HH; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., van Lieshout L; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., van Dam GJ; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., van Amerongen-Westra IM; Center for Cell and Gene Therapy, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Meij P; Center for Cell and Gene Therapy, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Corstjens PLAM; Department of Cell and Chemical Biology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Jochems SP; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., van Diepen A; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Yazdanbakhsh M; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Hokke CH; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands., Roestenberg M; Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, the Netherlands. Electronic address: M.Roestenberg@lumc.nl.

Publikováno v: EBioMedicine [EBioMedicine] 2023 Nov; Vol. 97, pp. 104832. Date of Electronic Publication: 2023 Oct 12.

Candidate gene family-based and case-control studies of susceptibility to high Schistosoma mansoni worm burden in African children: a protocol

Autor: Nyangiri, Oscar A, Edwige, Sokouri A, Koffi, Mathurin, Mewamba, Estelle, Simo, Gustave, Namulondo, Joyce, Mulindwa, Julius, Nassuuna, Jacent, Elliott, Alison, Karume, Kévin, Mumba, Dieudonne, Corstjens, PLAM, Casacuberta-Partal, M, van Dam, GJ, Bucheton, Bruno, Noyes, Harry, Matovu, Enock, TrypanoGEN+ Research Group of the H3Africa Consortium

Background: Approximately 25% of the risk of Schistosoma mansoni is associated with host genetic variation. We will test 24 candidate genes, mainly in the T h2 and T h17 pathways, for association with S. mansoni infection intensity in four African co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::d133259277d682b197ccca08c79f375a

Repeated doses of Praziquantel in Schistosomiasis Treatment (RePST) - single versus multiple praziquantel treatments in school-aged children in Côte d'Ivoire: a study protocol for an open-label, randomised controlled trial.

Autor: Hoekstra, P. T.¹ pthoekstra@lumc.nl, Casacuberta Partal, M.¹ m.casacuberta_partal@lumc.nl, Amoah, A. S.¹ a.s.amoah@lumc.nl, van Lieshout, L.¹ e.a.van_lieshout@lumc.nl, Corstjens, P. L. A. M.² p.corstjens@lumc.nl, Tsonaka, S.³ s.tsonaka@lumc.nl, Assaré, R. K.^4,5,6,7 hrufinass@yahoo.fr, Silué, K. D.^6,7 kigbafori.silue@gmail.com, Meité, A.⁸ aboulaye_meite77@yahoo.fr, N'Goran, E. K.^6,7 eliezerngoran@yahoo.fr, N'Gbesso, Y. K.⁹ koutouann@yahoo.fr, Roestenberg, M.¹ m.roestenberg@lumc.nl, Knopp, S.^4,5 s.knopp@swisstph.ch, Utzinger, J.^4,5 juerg.utzinger@swisstph.ch, Coulibaly, J. T.^4,5,6,7 couljeanvae@yahoo.fr, van Dam, G. J.¹ govert@lumc.nl

Publikováno v: BMC Infectious Diseases. 12/14/2018, Vol. 18 Issue 1, p1-10. 10p. 2 Diagrams.

Fine-scale mapping of Schistosoma mansoni infections and infection intensities in sub-districts of Makenene in the Centre region of Cameroon.

Autor: Mewamba EM; Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Tiofack AAZ; Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Kamdem CN; Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Tchounkeu EY; Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Tatang RJA; Research Unit of Biology and Applied Ecology, Department of Animal Biology, Faculty of Science, University of Dschang, Dschang, Cameroon., Mengoue LET; Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Mbagnia MCT; Parasitology and Ecology Laboratory, Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon., Njiokou F; Parasitology and Ecology Laboratory, Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.; Centre for Research in Infectious Diseases, Yaoundé, Cameroon., Casacuberta-Partal M; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Womeni HM; Unité de Recherche de Biochimie, des plantes Médicinales, des Sciences alimentaires et Nutrition, University of Dschang, Dschang, Cameroon., Simo G; Molecular Parasitology and Entomology Unit, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.

Publikováno v: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2022 Oct 13; Vol. 16 (10), pp. e0010852. Date of Electronic Publication: 2022 Oct 13 (Print Publication: 2022).