Systematic review of treatment intensification using novel agents for chemoradiotherapy in rectal cancer

Autor: Clifford, R, Govindarajah, N, Parsons, JL, Gollins, S, West, NP, Vimalachandran, D

Publikováno v: The British Journal of Surgery
British Journal of Surgery

Background With the well established shift to neoadjuvant treatment for locally advanced rectal cancer, there is increasing focus on the use of radiosensitizers to improve the efficacy and tolerability of radiotherapy. There currently exist few rando

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4d21e46b6119edec2a8bbcb9be510287
http://europepmc.org/articles/PMC6282533

The human DNA glycosylases NEIL1 and NEIL3 excise psoralen-induced DNA-DNA cross-links in a four-stranded DNA structure

Autor: Martin, PR, Couve, S, Zutterling, C, Albelazi, MS, Groisman, R, Matkarimov, BT, Parsons, JL, Elder, RH, Saparbaev, MS

Publikováno v: Scientific Reports
SCIENTIFIC REPORTS
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-17693-4⟩

Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand separation. Previously, we demonstrated that the bacterial and\ud human DNA glycosylases Nei and NEIL1 excise unhooked p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8082e94d19162be519f8fed33a14cf6e

End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair

Autor: Parsons, JL, Dianova, II, Boswell, E, Weinfeld, M, Dianov, GL

Ionizing radiation, oxidative stress and endogenous DNA-damage processing can result in a variety of single-strand breaks with modified 5' and/or 3' ends. These are thought to be one of the most persistent forms of DNA damage and may threaten cell su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0de4551bb93672aec06a829afb2d2dd1
https://doi.org/10.1111/j.1742-4658.2005.04962.x

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