Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19.

Autor: Dallan B; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., Proietto D; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., De Laurentis M; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., Gallerani E; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., Martino M; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., Ghisellini S; Laboratory of Clinical Pathology, University Hospital St. Anna, Ferrara, Italy., Zurlo A; Department of Medical Sciences, University of Ferrara, Geriatrics Unit, University Hospital of Ferrara, Ferrara, Italy., Volpato S; Department of Medical Sciences, University of Ferrara, Geriatrics Unit, University Hospital of Ferrara, Ferrara, Italy., Govoni B; Department of Medical Sciences, University of Ferrara, Geriatrics Unit, University Hospital of Ferrara, Ferrara, Italy., Borghesi M; Department of Economics and Management, University of Ferrara, Ferrara, Italy., Albanese V; Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy., Appay V; Université de Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, Bordeaux, France., Bonnini S; Department of Economics and Management, University of Ferrara, Ferrara, Italy., Llewellyn-Lacey S; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK., Pacifico S; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., Grumiro L; Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy., Brandolini M; Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy., Semprini S; Unit of Microbiology, Greater Romagna Area Hub Laboratory, Cesena, Italy., Sambri V; Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.; Unit of Microbiology, Greater Romagna Area Hub Laboratory, Cesena, Italy., Ladell K; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK., Parry HM; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK., Moss PAH; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK., Price DA; Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.; Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, UK., Caputo A; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., Gavioli R; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy., Nicoli F; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy. francesco.nicoli@unife.it.

Publikováno v: Nature aging [Nat Aging] 2024 Aug; Vol. 4 (8), pp. 1121-1136. Date of Electronic Publication: 2024 Jun 25.

Protocol for a multicentre randomised controlled trial examining the effects of temporarily pausing Bruton tyrosine kinase inhibitor therapy to coincide with SARS-CoV-2 vaccination and its impact on immune responses in patients with chronic lymphocytic leukaemia.

Autor: Barber VS; Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Oxford Clinical Trials Research Unit (OCTRU), University of Oxford, Oxford, UK., Peckham N; Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Oxford Clinical Trials Research Unit (OCTRU), University of Oxford, Oxford, UK., Duley L; Nottingham Clinical Trials Unit, University of Nottingham, Nottingham, UK., Francis A; Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Oxford Clinical Trials Research Unit (OCTRU), University of Oxford, Oxford, UK., Abhishek A; Academic Rheumatology, University of Nottingham, Nottingham, UK., Moss P; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK., Cook JA; Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Oxford Clinical Trials Research Unit (OCTRU), University of Oxford, Oxford, UK., Parry HM; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK h.m.parry@bham.ac.uk.

Publikováno v: BMJ open [BMJ Open] 2023 Sep 28; Vol. 13 (9), pp. e077946. Date of Electronic Publication: 2023 Sep 28.

SARS-CoV-2 vaccine responses following CD20-depletion treatment in patients with haematological and rheumatological disease: a West Midlands Research Consortium study.

Autor: Shields AM; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.; Department of Clinical Immunology, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK., Venkatachalam S; Department of Rheumatology, The Royal Wolverhampton NHS Trust, Wolverhampton, UK., Shafeek S; Department of Haematology, Worcestershire Acute NHS Trust, Worcester, UK., Paneesha S; Department of Haematology, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK., Ford M; Department of Rheumatology, The Royal Wolverhampton NHS Trust, Wolverhampton, UK., Sheeran T; Department of Rheumatology, The Royal Wolverhampton NHS Trust, Wolverhampton, UK., Kelly M; Department of Haematology, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK., Qureshi I; Department of Haematology, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK., Salhan B; Department of Haematology, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK., Karim F; Department of Haematology, The Royal Wolverhampton NHS Trust, Wolverhampton, UK., De Silva N; Department of Haematology, The Royal Wolverhampton NHS Trust, Wolverhampton, UK., Stones J; Department of Haematology, The Royal Wolverhampton NHS Trust, Wolverhampton, UK., Lee S; Department of Haematology, The Royal Wolverhampton NHS Trust, Wolverhampton, UK., Khawaja J; Department of Haematology, The Royal Wolverhampton NHS Trust, Wolverhampton, UK., Kaudlay PK; Department of Haematology, The Royal Wolverhampton NHS Trust, Wolverhampton, UK., Whitmill R; Department of Haematology, The Royal Wolverhampton NHS Trust, Wolverhampton, UK., Kakepoto GN; Department of Haematology, The Royal Wolverhampton NHS Trust, Wolverhampton, UK., Parry HM; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.; Department of Haematology, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK., Moss P; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.; Department of Haematology, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK., Faustini SE; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK., Richter AG; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.; Department of Clinical Immunology, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK., Drayson MT; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.; Department of Clinical Immunology, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK., Basu S; Department of Haematology, The Royal Wolverhampton NHS Trust, Wolverhampton, UK.; Faculty of Science & Engineering, University of Wolverhampton, Wolverhampton, UK.

Publikováno v: Clinical and experimental immunology [Clin Exp Immunol] 2022 Jan 28; Vol. 207 (1), pp. 3-10.

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.

Autor: Shah S; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.; Institute of Cardiovascular Science, University College London, London, UK.; British Heart Foundation Research Accelerator, University College London, London, UK., Henry A; Institute of Cardiovascular Science, University College London, London, UK.; British Heart Foundation Research Accelerator, University College London, London, UK.; Institute of Health Informatics, University College London, London, UK., Roselli C; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Lin H; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA., Sveinbjörnsson G; deCODE genetics/Amgen Inc., Sturlugata 8, 101, Reykjavik, Iceland., Fatemifar G; British Heart Foundation Research Accelerator, University College London, London, UK.; Institute of Health Informatics, University College London, London, UK.; Health Data Research UK London, University College London, London, UK., Hedman ÅK; Cardiovascular Medicine unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden., Wilk JB; Pfizer Worldwide Research & Development, 1 Portland St, Cambridge, MA, USA., Morley MP; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Chaffin MD; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Helgadottir A; deCODE genetics/Amgen Inc., Sturlugata 8, 101, Reykjavik, Iceland., Verweij N; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Dehghan A; Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Campus, London, W2 1PG, UK.; MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, St Mary's Campus, London, W2 1PG, UK., Almgren P; Department of Clinical Sciences, Lund University, Malmö, Sweden., Andersson C; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Department of Cardiology, Herlev Gentofte Hospital, Herlev Ringvej 57, 2650, Herlev, Denmark., Aragam KG; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Ärnlöv J; Department of Neurobiology, Care Sciences and Society/ Section of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden.; School of Health and Social Sciences, Dalarna University, Falun, Sweden., Backman JD; Regeneron Genetics Center, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA., Biggs ML; Department of Biostatistics, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Bloom HL; Division of Cardiology, Department of Medicine, Emory University Medical Center, Atlanta, GA, USA., Brandimarto J; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Brown MR; Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, Texas, USA., Buckbinder L; Pfizer Worldwide Research & Development, 1 Portland St, Cambridge, MA, USA., Carey DJ; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.; Harvard Medical School, Boston, MA, 02115, USA., Chen X; Pfizer Worldwide Research & Development, 1 Portland St, Cambridge, MA, USA., Chen X; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Chung J; Regeneron Genetics Center, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA., Chutkow W; Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Cook JP; Department of Biostatistics, University of Liverpool, Liverpool, UK., Delgado GE; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany., Denaxas S; British Heart Foundation Research Accelerator, University College London, London, UK.; Institute of Health Informatics, University College London, London, UK.; Health Data Research UK London, University College London, London, UK.; The National Institute for Health Research University College London Hospitals Biomedical Research Centre, University College London, London, UK.; The Alan Turing Institute, London, United Kingdom., Doney AS; Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK., Dörr M; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Dudley SC; Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN, USA., Dunn ME; Regeneron Pharmaceuticals, Cardiovascular Research, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA., Engström G; Department of Clinical Sciences, Lund University, Malmö, Sweden., Esko T; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia., Felix SB; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Finan C; Institute of Cardiovascular Science, University College London, London, UK.; British Heart Foundation Research Accelerator, University College London, London, UK., Ford I; Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK., Ghanbari M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Ghasemi S; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Giedraitis V; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, 75185, Sweden., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA., Gottdiener JS; Department of Medicine, Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD, USA., Gross S; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Guðbjartsson DF; deCODE genetics/Amgen Inc., Sturlugata 8, 101, Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, 101, Reykjavik, Iceland., Gutmann R; Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Haggerty CM; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA., van der Harst P; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands., Hyde CL; Pfizer Worldwide Research & Development, 1 Portland St, Cambridge, MA, USA., Ingelsson E; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, 94305, USA.; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Stanford Diabetes Research Center, Stanford University, Stanford, CA, 94305, USA., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, The Netherlands., Kavousi M; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Khaw KT; Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB2 0QQ, UK., Kleber ME; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Heidelberg, Germany., Køber L; Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Koekemoer A; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Lindgren CM; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., London B; Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USA., Lotta LA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Lovering RC; Institute of Cardiovascular Science, University College London, London, UK.; British Heart Foundation Research Accelerator, University College London, London, UK., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Magnusson P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Margulies KB; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., März W; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria., Melander O; Department of Internal Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Malmö, Sweden., Mordi IR; Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK., Morgan T; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.; Vanderbilt University School of Medicine, Nashville, TN, USA., Morris AD; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom., Morris AP; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Morrison AC; Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, Texas, USA., Nagle MW; Pfizer Worldwide Research & Development, 1 Portland St, Cambridge, MA, USA., Nelson CP; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Niessner A; Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria., Niiranen T; National Institute for Health and Welfare, Helsinki, Finland.; Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland., O'Donoghue ML; TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA., Owens AT; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Palmer CNA; Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK., Parry HM; Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK., Perola M; National Institute for Health and Welfare, Helsinki, Finland., Portilla-Fernandez E; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Psaty BM; Department of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA., Rice KM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.; Harvard Medical School, Boston, MA, 02115, USA., Romaine SPR; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Rotter JI; The Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Salo P; National Institute for Health and Welfare, Helsinki, Finland., Salomaa V; National Institute for Health and Welfare, Helsinki, Finland., van Setten J; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands., Shalaby AA; Division of Cardiology, Department of Medicine, University of Pittsburgh Medical Center and VA Pittsburgh HCS, Pittsburgh, PA, USA., Smelser DT; Department of Molecular and Functional Genomics, Geisinger, Danville, PA, USA., Smith NL; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research & Development, Seattle, WA, USA., Stender S; Department of Clinical Biochemistry, Copenhagen University Hospital, Herlev and Gentofte, København, Denmark., Stott DJ; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom., Svensson P; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.; Department of Cardiology, Södersjukhuset, Stockholm, Sweden., Tammesoo ML; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia., Taylor KD; Institute for Translational Genomics and Population Sciences, LABiomed and Departments of Pediatrics at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Teder-Laving M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, 51010, Estonia., Teumer A; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Thorgeirsson G; deCODE genetics/Amgen Inc., Sturlugata 8, 101, Reykjavik, Iceland.; Division of Cardiology, Department of Internal Medicine, Landspitali, National University Hospital of Iceland, Hringbraut, 101, Reykjavik, Iceland., Thorsteinsdottir U; deCODE genetics/Amgen Inc., Sturlugata 8, 101, Reykjavik, Iceland.; Faculty of Medicine, Department of Medicine, University of Iceland, Saemundargata 2, 101, Reykjavik, Iceland., Torp-Pedersen C; Department of Epidemiology and Biostatistics, Aalborg University Hospital, Aalborg, Denmark.; Department of Health, Science and Technology, Aalborg University Hospital, Aalborg, Denmark.; Departments of Cardiology, Aalborg University Hospital, Aalborg, Denmark., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands., Tyl B; Translational and Clinical Research, Servier Cardiovascular Center for Therapeutic Innovation, 50 rue Carnot, 92284, Suresnes, France., Uitterlinden AG; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Veluchamy A; Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK., Völker U; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Voors AA; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Wang X; Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Waterworth D; Human Genetics, GlaxoSmithKline, Collegeville, PA, USA., Weeke PE; Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Weiss R; Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, OH, USA., Wiggins KL; Department of Medicine, University of Washington, Seattle, WA, USA., Xing H; Novartis Institutes for Biomedical Research, Cambridge, MA, USA., Yerges-Armstrong LM; Human Genetics, GlaxoSmithKline, Collegeville, PA, USA., Yu B; Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, Texas, USA., Zannad F; Université de Lorraine, CHU de Nancy, Inserm and INI-CRCT (F-CRIN), Institut Lorrain du Coeur et des Vaisseaux, 54500, Vandoeuvre Lès, Nancy, France., Zhao JH; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Hemingway H; British Heart Foundation Research Accelerator, University College London, London, UK.; Institute of Health Informatics, University College London, London, UK.; Health Data Research UK London, University College London, London, UK.; BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom., Samani NJ; Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., McMurray JJV; BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom., Yang J; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia., Visscher PM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, 4072, Australia.; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, 4072, Australia., Newton-Cheh C; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA., Malarstig A; Cardiovascular Medicine unit, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.; Pfizer Worldwide Research & Development, 1 Portland St, Cambridge, MA, USA., Holm H; deCODE genetics/Amgen Inc., Sturlugata 8, 101, Reykjavik, Iceland., Lubitz SA; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Sattar N; BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom., Holmes MV; Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK.; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospital, Oxford, UK., Cappola TP; Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Asselbergs FW; Institute of Cardiovascular Science, University College London, London, UK.; British Heart Foundation Research Accelerator, University College London, London, UK.; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands., Hingorani AD; Institute of Cardiovascular Science, University College London, London, UK.; British Heart Foundation Research Accelerator, University College London, London, UK., Kuchenbaecker K; Division of Psychiatry, University College of London, London, W1T 7NF, UK.; UCL Genetics Institute, University College London, London, WC1E 6BT, UK., Ellinor PT; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Lang CC; Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK., Stefansson K; deCODE genetics/Amgen Inc., Sturlugata 8, 101, Reykjavik, Iceland.; Faculty of Medicine, Department of Medicine, University of Iceland, Saemundargata 2, 101, Reykjavik, Iceland., Smith JG; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.; Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, Sweden., Vasan RS; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA.; Sections of Cardiology, Preventive Medicine and Epidemiology, Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, MA, USA., Swerdlow DI; Institute of Cardiovascular Science, University College London, London, UK., Lumbers RT; British Heart Foundation Research Accelerator, University College London, London, UK. t.lumbers@ucl.ac.uk.; Institute of Health Informatics, University College London, London, UK. t.lumbers@ucl.ac.uk.; Health Data Research UK London, University College London, London, UK. t.lumbers@ucl.ac.uk.; Bart's Heart Centre, St. Bartholomew's Hospital, London, UK. t.lumbers@ucl.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2020 Jan 09; Vol. 11 (1), pp. 163. Date of Electronic Publication: 2020 Jan 09.

Long-Term Ibrutinib Therapy Reverses CD8 ⁺ T Cell Exhaustion in B Cell Chronic Lymphocytic Leukaemia.

Autor: Parry HM; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom., Mirajkar N; Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom., Cutmore N; St James' University Hospital, Leeds Teaching Hospitals Trust, Leeds, United Kingdom., Zuo J; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom., Long H; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom., Kwok M; Institute of Cancer and Genomic Sciences University of Birmingham, Birmingham, United Kingdom., Oldrieve C; Institute of Cancer and Genomic Sciences University of Birmingham, Birmingham, United Kingdom., Hudson C; Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham, United Kingdom., Stankovic T; Institute of Cancer and Genomic Sciences University of Birmingham, Birmingham, United Kingdom., Paneesha S; Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom., Kelly M; Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom., Begum J; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom., McSkeane T; Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, United Kingdom., Pratt G; Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom., Moss P; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.

Publikováno v: Frontiers in immunology [Front Immunol] 2019 Dec 12; Vol. 10, pp. 2832. Date of Electronic Publication: 2019 Dec 12 (Print Publication: 2019).