Omnibus proteome-wide association study identifies 43 risk genes for Alzheimer disease dementia

Autor: Hu, Tingyang, Parrish, Randy L., Dai, Qile, Buchman, Aron S., Tasaki, Shinya, Bennett, David A., Seyfried, Nicholas T., Epstein, Michael P., Yang, Jingjing

Publikováno v: In The American Journal of Human Genetics 5 September 2024 111(9):1848-1863

Proteome-wide association studies using summary pQTL data of three tissues identified 30 risk genes of Alzheimer's disease dementia.

Autor: Hu T; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Division of Biostatistics and Bioinformatics, Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA., Liu Q; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Department of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA, 30322, USA., Dai Q; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Department of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA, 30322, USA., Parrish RL; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA.; Department of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA, 30322, USA., Buchman AS; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA., Tasaki S; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA., Seyfried NT; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA., Wang Y; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA., De Jager PL; Center for Translational and Computational Neuroimmunology, Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY10032, USA., Epstein MP; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA., Yang J; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Sep 04. Date of Electronic Publication: 2024 Sep 04.

TIGAR-V2: Efficient TWAS tool with nonparametric Bayesian eQTL weights of 49 tissue types from GTEx V8.

Autor: Parrish RL; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Gibson GC; School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA., Epstein MP; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Yang J; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.

Publikováno v: HGG advances [HGG Adv] 2021 Nov 04; Vol. 3 (1), pp. 100068. Date of Electronic Publication: 2021 Nov 04 (Print Publication: 2022).