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Akademický článek

Mitochondrial DNA as a potential tool for early cancer detection

Autor: Parr Ryan L, Dakubo Gabriel D, Thayer Robert E, McKenney Keith, Birch-Machin Mark A

Publikováno v: Human Genomics, Vol 2, Iss 4, Pp 252-257 (2006)

Abstract The recent surge in mitochondrial research has been driven by the identification of mitochondria-associated diseases and the role of mitochondria in apoptosis. Both of these aspects have identified mitochondrial analysis as a vital component

Externí odkaz: https://doaj.org/article/1d2d57d5aac945d9875a8272c06b80be

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Akademický článek

Mitochondrial and nuclear genomics and the emergence of personalized medicine

Autor: Parr Ryan L, Martin Luis H

Publikováno v: Human Genomics, Vol 6, Iss 1, p 3 (2012)

Abstract Developing early detection biosensors for disease has been the long‒held goal of the Human Genome Project, but with little success. Conversely, the biological properties of the mitochondrion coupled with the relative simplicity of the mito

Externí odkaz: https://doaj.org/article/7e444a1e0a304c6c84fa65c6f0d776a3

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Akademický článek

Facile whole mitochondrial genome resequencing from nipple aspirate fluid using MitoChip v2.0

Autor: Thayer Robert E, Wagner Paul D, Robinson Kerry, Wittock Roy, Maki Katrina, Reguly Brian, Maki Jennifer, Maragh Samantha, Maggrah Andrea, Jakupciak John P, Gehman Ken, Gehman Teresa, Srivastava Sudhir, Ngom Alioune, Dakubo Gabriel D, Parr Ryan L

Publikováno v: BMC Cancer, Vol 8, Iss 1, p 95 (2008)

Abstract Background Mutations in the mitochondrial genome (mtgenome) have been associated with many disorders, including breast cancer. Nipple aspirate fluid (NAF) from symptomatic women could potentially serve as a minimally invasive sample for brea

Externí odkaz: https://doaj.org/article/16ff12f649f44cd8b099f2dcba916fa8

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Akademický článek

Clinical implications and utility of field cancerization

Autor: Birch-Machin Mark A, Jakupciak John P, Dakubo Gabriel D, Parr Ryan L

Publikováno v: Cancer Cell International, Vol 7, Iss 1, p 2 (2007)

Abstract Cancer begins with multiple cumulative epigenetic and genetic alterations that sequencially transform a cell, or a group of cells in a particular organ. The early genetic events might lead to clonal expansion of pre-neoplastic daughter cells

Externí odkaz: https://doaj.org/article/d4329fc01ccb41e486ee7b5f72eff045

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Akademický článek

The pseudo-mitochondrial genome influences mistakes in heteroplasmy interpretation

Autor: Wittock Roy, Aguirre Andrea, Dakubo Gabriel D, Reguly Brian, Maki Jennifer, Parr Ryan L, Robinson Kerry, Jakupciak John P, Thayer Robert E

Publikováno v: BMC Genomics, Vol 7, Iss 1, p 185 (2006)

Abstract Background Nuclear mitochondrial pseudogenes (numts) are a potential source of contamination during mitochondrial DNA PCR amplification. This possibility warrants careful experimental design and cautious interpretation of heteroplasmic resul

Externí odkaz: https://doaj.org/article/dce8bc235f2b495aa2b144c8c5aed410

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