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pro vyhledávání: '"Parnia Rahnamay Farnood"'
Publikováno v:
Current Molecular Pharmacology. 16:71-82
Abstract: The most prevalent primary bone malignancy among children and adolescents is osteosarcoma. The high mortality rate of osteosarcoma is due to lung metastasis. Despite the development of multi-agent chemotherapy and surgical resection, patien
Autor:
Liaosadat Mirsafaei, Zatollah Asemi, Bahman Yousefi, Parnia Rahnamay Farnood, Romina Danesh Pazhooh, Hamed Mirzaei
Publikováno v:
DNA Repair. 104:103142
The mammalian target of rapamycin (mTOR) is a conserved serine/threonine-protein kinase, comprising two subunit protein complexes: mTORC1 and mTORC2. In response to insult and cancer, the mTOR pathway plays a crucial role in regulating growth, metabo
Publikováno v:
DNA Repair. 103:103116
Pancreatic cancer (PC) is among fatal malignancies, with a dismal prognosis and a low survival rate of 5-10%. In both sporadic and inherited PC, gene alterations, such as BRCA1/2, PALB2, and ATM, can occur frequently. Currently, surgery, chemo- and r