Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

Autor: Elizabeth Spangenberg, Paul L. Severson, Lindsay A. Hohsfield, Joshua Crapser, Jiazhong Zhang, Elizabeth A. Burton, Ying Zhang, Wayne Spevak, Jack Lin, Nicole Y. Phan, Gaston Habets, Andrey Rymar, Garson Tsang, Jason Walters, Marika Nespi, Parmveer Singh, Stephanie Broome, Prabha Ibrahim, Chao Zhang, Gideon Bollag, Brian L. West, Kim N. Green

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)

Genetics implicate microglia in Alzheimer’s disease pathogenesis, but their roles remain unclear. Here, the authors find that microglial depletion in a mouse model of Alzheimer’s disease impairs plaque formation and that Aβ-induced changes in ne

Externí odkaz: https://doaj.org/article/ab83dec7482d44a28b96b168ea75f0ff

Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy

Autor: Lukas Henning, Henrike Antony, Annika Breuer, Julia Müller, Gerald Seifert, Etienne Audinat, Parmveer Singh, Frederic Brosseron, Michael T. Heneka, Christian Steinhäuser, Peter Bedner

Publikováno v: Glia 71(2), 168-186 (2023). doi:10.1002/glia.24265

Extensive microglia reactivity has been well described in human and experimental temporal lobe epilepsy (TLE). To date, however, it is not clear whether and based on which molecular mechanisms microglia contribute to the development and progression o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7febe93f8d8c48e53108d8572a2f2a1d

Propagation of human prostate tissue from induced pluripotent stem cells

Autor: Omar E. Franco, Anastasia C. Hepburn, Adriana Buskin, Susan E. Crawford, Simon W. Hayward, Ian G. Mills, Luke Gaughan, M Moad, Rakesh Heer, Parmveer Singh, Craig N. Robson, Emma L Curry, Rebecca E Steele, Laura Wilson

Publikováno v: Hepburn, A C, Curry, E L, Moad, M, Steele, R E, Franco, O E, Wilson, L, Singh, P, Buskin, A, Crawford, S E, Gaughan, L, Mills, I G, Hayward, S W, Robson, C N & Heer, R 2020, ' Propagation of human prostate tissue from induced pluripotent stem cells ', Stem cells translational medicine . https://doi.org/10.1002/sctm.19-0286
Stem Cells Translational Medicine, Vol 9, Iss 7, Pp 734-745 (2020)
STEM CELLS Translational Medicine
Stem Cells Translational Medicine

Primary culture of human prostate organoids and patient‐derived xenografts is inefficient and has limited access to clinical tissues. This hampers their use for translational study to identify new treatments. To overcome this, we established a comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb605acdb40354aa09e0646f93a13357
https://doi.org/10.1002/sctm.19-0286

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model

Autor: Gaston Habets, Parmveer Singh, Gideon Bollag, Brian L. West, Lindsay A. Hohsfield, Andrey Rymar, Prabha N. Ibrahim, Stephanie Broome, Joshua D. Crapser, Garson Tsang, Elizabeth E. Spangenberg, Marika Nespi, Elizabeth A. Burton, Paul Severson, Jason Walters, Kim N. Green, Chao Zhang, Jack Lin, Jiazhong Zhang, Wayne Spevak, Ying Zhang, Nicole Y. Phan

Publikováno v: Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
Nature Communications

Many risk genes for the development of Alzheimer’s disease (AD) are exclusively or highly expressed in myeloid cells. Microglia are dependent on colony-stimulating factor 1 receptor (CSF1R) signaling for their survival. We designed and synthesized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed40cee7378de96501838a791a1537ee
https://escholarship.org/uc/item/6062s7cq

Genetic backgrounds and modifier genes of NTD mouse models: An opportunity for greater understanding of the multifactorial etiology of neural tube defects

Autor: Renee Y M, Leduc, Parmveer, Singh, Heather E, McDermid

Publikováno v: Birth defects research. 109(2)

Neurulation, the early embryonic process of forming the presumptive brain and spinal cord, is highly complex and involves hundreds of genes in multiple genetic pathways. Mice have long served as a genetic model for studying human neurulation, and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::986e7293b60daf8d152568ff93bf95c4
https://pubmed.ncbi.nlm.nih.gov/27768235