Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Parmjit S, Jat"'
Autor:
Junhui Hu, Ping Tan, Moe Ishihara, Nicholas A. Bayley, Shiruyeh Schokrpur, Jeremy G. Reynoso, Yangjun Zhang, Raymond J. Lim, Camelia Dumitras, Lu Yang, Steven M. Dubinett, Parmjit S. Jat, Jacques Van Snick, Jiaoti Huang, Arnold I. Chin, Robert M. Prins, Thomas G. Graeber, Hua Xu, Lily Wu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-16 (2023)
Abstract Loss of function of the von Hippel-Lindau (VHL) tumor suppressor gene is a hallmark of clear cell renal cell carcinoma (ccRCC). The importance of heterogeneity in the loss of this tumor suppressor has been under reported. To study the impact
Externí odkaz:
https://doaj.org/article/7fbb896806994806aeb3daa83568734f
Autor:
Madeleine Reilly, Iryna Benilova, Azadeh Khalili-Shirazi, Christian Schmidt, Parvin Ahmed, Daniel Yip, Parmjit S. Jat, John Collinge
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract There is an urgent need to develop disease-modifying therapies to treat neurodegenerative diseases which pose increasing challenges to global healthcare systems. Prion diseases, although rare, provide a paradigm to study neurodegenerative de
Externí odkaz:
https://doaj.org/article/6c3d427e537748449f547bcad8e6d4f9
Autor:
Ruchi Kumari, Holger Hummerich, Xu Shen, Martin Fischer, Larisa Litovchick, Sibylle Mittnacht, James A. DeCaprio, Parmjit S. Jat
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Cellular senescence is a stable cell cycle arrest that normal cells undergo after a finite number of divisions, in response to a variety of intrinsic and extrinsic stimuli. Although senescence is largely established and maintained by the p53
Externí odkaz:
https://doaj.org/article/6e66597928294524a625be5f57918552
Autor:
James Dylewski, Evgenia Dobrinskikh, Linda Lewis, Pantipa Tonsawan, Makoto Miyazaki, Parmjit S Jat, Judith Blaine
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0209732 (2019)
Proteinuria is strongly associated with kidney disease progression but the mechanisms underlying podocyte handling of serum proteins such as albumin and IgG remain to be elucidated. We have previously shown that albumin and IgG are transcytosed by po
Externí odkaz:
https://doaj.org/article/6429773ab2654fc4a6ad7bd6706fe950
Autor:
Savroop K. Bhamra, Parineeta Arora, Laszlo L. P. Hosszu, Jan Bieschke, Anthony R. Clarke, John Collinge, Parmjit S. Jat
Mutational analysis of the cellular prion protein (PrPC) has revealed various regions of the protein that modulate prion propagation. However, most approaches involve deletions, insertions, or replacements in the presence of the wild-type cellular pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49405a2f604d3a2ab0b884ab8a548b11
https://doi.org/10.1101/2023.01.19.524767
https://doi.org/10.1101/2023.01.19.524767
Autor:
Holger Hummerich, Xu Shen, Martin Fischer, James A. DeCaprio, Ruchi Kumari, Sibylle Mittnacht, Parmjit S. Jat, Larisa Litovchick
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Cellular senescence is a stable cell cycle arrest that normal cells undergo after a finite number of divisions, in response to a variety of intrinsic and extrinsic stimuli. Although senescence is largely established and maintained by the p53/p21WAF1/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17cde7e195b624eeb4f26a347456c49e
https://doaj.org/article/6e66597928294524a625be5f57918552
https://doaj.org/article/6e66597928294524a625be5f57918552
Autor:
Savroop Bhamra, Parineeta Arora, Szymon W. Manka, Christian Schmidt, Craig Brown, Melissa L. D. Rayner, Peter-Christian Klöhn, Anthony R. Clarke, John Collinge, Parmjit S. Jat
Prions consist of assemblies of aberrantly folded cellular prion protein (PrPC) upon template-assisted conversion and propagation of disease-associated PrP. To dissect the N-terminal residues critical for efficient prion propagation, we generated a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13379c73087367c006d43d47569dab4a
https://doi.org/10.1101/2022.08.08.503133
https://doi.org/10.1101/2022.08.08.503133
Autor:
Artur Brandt, Katharina Löhers, Manfred Beier, Barbara Leube, Carmen de Torres, Jaume Mora, Parineeta Arora, Parmjit S Jat, Brigitte Royer-Pokora
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155561 (2016)
We describe a stromal predominant Wilms tumor with focal anaplasia and a complex, tumor specific chromosome 11 aberration: a homozygous deletion of the entire WT1 gene within a heterozygous 11p13 deletion and an additional region of uniparental disom
Externí odkaz:
https://doaj.org/article/b4d0897ae4a74e828f5ff01196048094
Autor:
Hua Xu, Jacques Van Snick, Beatrice S. Knudsen, Shiruyeh Schokrpur, Moe Ishihara, Thomas G. Graeber, Lily Wu, Jeremy Reynoso, Parmjit S. Jat, Robert M. Prins, Ping Tan, Junhui Hu, Nicholas Bayley, Arnold I. Chin
To study the impact of intratumoral VHL heterogeneity observed in patient ccRCC primary tumors, we engineered VHL gene deletion in three RCC models, including a new primary tumor cell line derived from an aggressive metastatic ccRCC. The VHL gene-del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db65058107880b2efa66345fe2735fb7
https://doi.org/10.21203/rs.3.rs-846239/v1
https://doi.org/10.21203/rs.3.rs-846239/v1
Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence.
Autor:
Alessio Iannetti, Adeline C Ledoux, Susan J Tudhope, Hélène Sellier, Bo Zhao, Sophia Mowla, Adam Moore, Holger Hummerich, Benjamin E Gewurz, Simon J Cockell, Parmjit S Jat, Elaine Willmore, Neil D Perkins
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004642 (2014)
There are two major pathways leading to induction of NF-κB subunits. The classical (or canonical) pathway typically leads to the induction of RelA or c-Rel containing complexes, and involves the degradation of IκBα in a manner dependent on IκB ki
Externí odkaz:
https://doaj.org/article/aaddeaccf33b4b40bce0cfbdad0a4454