Výsledky vyhledávání - "Parmjit Bahra"

Exposing rodents to a combination of tobacco smoke and lipopolysaccharide results in an exaggerated inflammatory response in the lung

Autor: Chris Poll, N Dale, KH Banner, F Raza, Parmjit Bahra, Elizabeth Hardaker, Freeman

Publikováno v: British Journal of Pharmacology. 160:1985-1996

BACKGROUND AND PURPOSE Acute exacerbations of chronic obstructive pulmonary disease (COPD), which are often associated with respiratory infections, are defined as a worsening of symptoms that require a change in medication. Exacerbations are characte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7edb286f9f44a5f31f0ec704f04b179
https://doi.org/10.1111/j.1476-5381.2010.00857.x

Zobrazit plný text záznamu

Comparison of Cigarette Smoke-Induced Acute Inflammation in Multiple Strains of Mice and the Effect of a Matrix Metalloproteinase Inhibitor on These Responses

Autor: Parmjit Bahra, Wing-Yan Heidi Wan, Gillian Kinnear, Abigail Morris, Christopher S. Stevenson, Daniel Wyss

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 327:851-862

The activities of proteases in the lung, specifically matrix metalloproteinases (MMPs), have been implicated in driving the inflammation and lung destruction observed in smokers with chronic obstructive pulmonary disease. Here, our aims were to compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a547ad11dd5bffccd6f5f9cbed4daf4
https://doi.org/10.1124/jpet.108.140848

Zobrazit plný text záznamu

P2Y2-receptor-mediated activation of a contralateral, lanthanide-sensitive calcium entry pathway in the human airway epithelium

Autor: Su Li, Henry Danahay, Parmjit Bahra, Jonathan Mesher, Christopher T. Poll

Publikováno v: British Journal of Pharmacology. 143:91-98

1. Receptor-mediated calcium entry (RMCE) was examined in well-differentiated cultures of normal human bronchial epithelial cells (HBECs). Changes in intracellular free Ca(2+) ([Ca(2+)](i)) were quantified using fluorescence ratio imaging of Fura-2-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f359806ef34858ddc2e06c6235c8f5aa
https://doi.org/10.1038/sj.bjp.0705913

Zobrazit plný text záznamu

The ion channel transient receptor potential melastatin-2 does not play a role in inflammatory mouse models of chronic obstructive pulmonary diseases

Autor: Daniel Wyss, Parmjit Bahra, Benjamin Cochin de Billy, Liz Hardaker, Mark Freeman, Natalia Kupfer, Alexandre Trifilieff

Publikováno v: Respiratory Research
Respiratory Research, Vol 13, Iss 1, p 30 (2012)

Background There is strong evidence that oxidative stress is associated with the pathogenesis of chronic obstructive pulmonary disease (COPD). The transient receptor potential melastatin-2 (TRPM2) is an oxidative stress sensing channel that is expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c572d8a7ac7cdcfc4811e15ca165eaa
https://pubmed.ncbi.nlm.nih.gov/22475739

Zobrazit plný text záznamu

Expression of transient receptor potential C6 channels in human lung macrophages

Autor: Parmjit Bahra, Christopher T. Poll, Louise E. Donnelly, Mariana Oana Popa, Onn Min Kon, Gabor Jarai, Andrew G. Nicholson, Su Li, John Westwick, Richard Russell, Tricia Finney-Hayward, Peter J. Barnes, Martin Gosling

Publikováno v: American journal of respiratory cell and molecular biology. 43(3)

Chronic obstructive pulmonary disease (COPD) is associated with pulmonary inflammation with increased numbers of macrophages located in the parenchyma. These macrophages have the capacity to mediate the underlying pathophysiology of COPD; therefore,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b63c8fe250b9d48d9466b6d833f8d25
https://pubmed.ncbi.nlm.nih.gov/19843708

Zobrazit plný text záznamu

Leukotriene B4 release by human lung macrophages via receptor- not voltage-operated Ca2+ channels

Autor: P. J. Barnes, Andrew G. Nicholson, John Westwick, Richard Russell, Louise E. Donnelly, Peter Fenwick, Parmjit Bahra, Tricia Finney-Hayward, S. Li, Christopher T. Poll, Paul Ford

Publikováno v: The European respiratory journal. 33(5)

Increased numbers of macrophages and neutrophils in the lung is a key feature of chronic obstructive pulmonary disease (COPD). The major neutrophil chemotactic agent in the airways of COPD patients is leukotriene (LT)B(4) and is released by macrophag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6b5b07ad47ff97fb890ac3d21dbf82
https://pubmed.ncbi.nlm.nih.gov/19164358

Zobrazit plný text záznamu

Activation of human TRPC6 channels by receptor stimulation

Autor: Parmjit Bahra, William P. Schilling, Su Li, Mark Estacion, Chris Poll, Martin Gosling, John Westwick, William G. Sinkins

Publikováno v: The Journal of biological chemistry. 279(21)

The human TRPC6 channel was expressed in human embryonic kidney (HEK) cells, and activity was monitored using the giga-seal technique. Whole cell membrane currents with distinctive inward and outward rectification were activated by carbachol (CCh) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1961b5427e91d78bcd1fca9d0110ec
https://pubmed.ncbi.nlm.nih.gov/15023993

Zobrazit plný text záznamu

Effects of pentoxifylline on the different steps during adhesion and transendothelial migration of flowing neutrophils

Autor: Jean-Luc Wautier, G.E. Rainger, Parmjit Bahra, Gerard B. Nash

Publikováno v: Cell biochemistry and function. 19(4)

We used a flow system to observe the stepwise adhesion and migration of neutrophils on cultured human umbilical vein endothelial cells (HUVEC) stimulated with tumour necrosis factor-α (TNF) for 4 h, and to evaluate the effects of pentoxifylline (PTX

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba030aa08bff602ec67541800b680b25
https://pubmed.ncbi.nlm.nih.gov/11746205

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání