Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Parminder Mankoo"'
Autor:
Chad J Creighton, Anadulce Hernandez-Herrera, Anders Jacobsen, Douglas A Levine, Parminder Mankoo, Nikolaus Schultz, Ying Du, Yiqun Zhang, Erik Larsson, Robert Sheridan, Weimin Xiao, Paul T Spellman, Gad Getz, David A Wheeler, Charles M Perou, Richard A Gibbs, Chris Sander, D Neil Hayes, Preethi H Gunaratne, Cancer Genome Atlas Research Network
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34546 (2012)
The Cancer Genome Atlas (TCGA) Network recently comprehensively catalogued the molecular aberrations in 487 high-grade serous ovarian cancers, with much remaining to be elucidated regarding the microRNAs (miRNAs). Here, using TCGA ovarian data, we su
Externí odkaz:
https://doaj.org/article/50dceea670724dfcb15c0e1ec548ae13
Autor:
Isaac M. Neuhaus, Adam Fries, Sean Clancy, Hobart W. Harris, Pooja Mehta, Joshua M. Moreau, Jingxian Zhang, Adil Daud, Margaret M. Lowe, Hsin-Wen Chang, Devi P. Boda, Parminder Mankoo, Ian C. Boothby, Michael Rosenblum, Bahar Zirak, Kelly M. Mahuron, J. Liu, Sofia V. Gearty, Matthew F. Krummel, Wilson Liao, Esther A. Kim, Tiffany C. Scharschmidt, Victoire Gouirand
Publikováno v:
J Immunol
Journal of immunology (Baltimore, Md. : 1950), vol 207, iss 7
Journal of immunology (Baltimore, Md. : 1950), vol 207, iss 7
Regulatory T cells (Tregs) reside in nonlymphoid tissues where they carry out unique functions. The molecular mechanisms responsible for Treg accumulation and maintenance in these tissues are relatively unknown. Using an unbiased discovery approach,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e0a7de97b4c559d4d34b5722204772
https://europepmc.org/articles/PMC8489406/
https://europepmc.org/articles/PMC8489406/
Publikováno v:
Cancer Research. 81:2244-2244
Background: Multi-omic single cell studies are revolutionizing knowledge of the tumor immune microenvironment and positioned to detect rare cell subsets that correlate with response to immunotherapy. DNA-barcoded antibody panels enable the unambiguou
Autor:
Charlene Manning, Fangxian Sun, Stephen L. Madden, Sherry Cao, Hongjing Qu, Richard C. Gregory, Robert J. Pomponio, Michele Sanicola-Nadel, Dmitri Wiederschain, Natalia Malkova, Gary Shapiro, Jean Cavallo, Christopher Winter, Tun Tun Lin, Joachim Theilhaber, Parminder Mankoo, Jack Pollard
Publikováno v:
Cancer Research. 78:5550-5550
TGFβ is a potent immunosuppressive cytokine, acting on multiple cell types of both the innate and adaptive immune systems. Emerging preclinical and clinical data implicate TGFβ in tumor immune evasion, poor prognosis and resistance to PD1/PDL1 dire
Autor:
Tatiana Nikolskaya, Hirohiko Kamiyama, Yuri Nikolsky, Philipp Angenendt, Rachel Karchin, Kenneth W. Kinzler, Manuel Hidalgo, Douglas Smith, Giovanni Parmigiani, Christine A. Iacobuzio-Donahue, Seung-Mo Hong, Eric S. Calhoun, James R. Eshleman, Siân Jones, Mihoko Kamiyama, Baojin Fu, Nickolas Papadopoulos, Elizabeth M. Jaffee, Bert Vogelstein, D. Williams Parsons, Victor E. Velculescu, Kimberly Walter, Hannah Carter, Anirban Maitra, Steven D. Leach, Alison P. Klein, Ming Tseh Lin, Antonio Jimeno, James Hartigan, Michael Goggins, Scott E. Kern, Parminder Mankoo, Ralph H. Hruban, Jimmy Lin, Xiaosong Zhang, Rebecca J. Leary
Publikováno v:
Science. 321:1801-1806
There are currently few therapeutic options for patients with pancreatic cancer, and new insights into the pathogenesis of this lethal disease are urgently needed. Toward this end, we performed a comprehensive genetic analysis of 24 pancreatic cancer
Autor:
Donald A. Bergstrom, Catherine Geslin, Jack Pollard, Marielle Chiron, Loic Vincent, Nina Baltes, Rebecca G. Bagley, Parminder Mankoo, Christophe Henry
Publikováno v:
Molecular cancer therapeutics. 13(6)
The recombinant fusion protein aflibercept (ziv-aflibercept in the United States) binds VEGF-A, VEGF-B, and placental growth factor (PlGF). The monoclonal antibody bevacizumab binds VEGF-A. Recent studies hypothesized that dual targeting of VEGF/PlGF
Autor:
Andrej Sali, Ben Webb, Marc A. Marti-Renom, Rachel Karchin, David T. Barkan, Hannah Carter, Libusha Kelly, Fred P. Davis, Parminder Mankoo, David Eramian, Narayanan Eswar, Ursula Pieper
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 2013, 42 (D1), pp.D336-D346. ⟨10.1093/nar/gkt1144⟩
Nucleic Acids Research, Oxford University Press, 2013, 42 (D1), pp.D336-D346. ⟨10.1093/nar/gkt1144⟩
Nucleic Acids Research, 2013, 42 (D1), pp.D336-D346. ⟨10.1093/nar/gkt1144⟩
Nucleic Acids Research, Oxford University Press, 2013, 42 (D1), pp.D336-D346. ⟨10.1093/nar/gkt1144⟩
International audience; ModBase (http://salilab.org/modbase) is a database of annotated comparative protein structure models. The models are calculated by ModPipe, an auto- mated modeling pipeline that relies primarily on Modeller for fold assignment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a2735948661a7cec74711881f165e9
https://hal-pasteur.archives-ouvertes.fr/pasteur-01414232
https://hal-pasteur.archives-ouvertes.fr/pasteur-01414232
Publikováno v:
Proteins. 75(2)
Somatic mutations in PIK3CA (phosphati-dylinositol-3 kinase, catalytic subunit, alpha isoform) are reported in breast and other human cancers to concentrate at hotspots within its kinase and helical domains. Most of these mutations cause kinase gain
Autor:
Alessandro Olivi, Sueli Mieko Oba Shinjo, Victor E. Velculescu, Siân Jones, Stephen T. Keir, Darell D. Bigner, Tatiana Nikolskaya, Luis A. Diaz, Xiaosong Zhang, Hanna Tekleab, Dana A. Busam, Robert L. Strausberg, Roger E. McLendon, Bert Vogelstein, D. Williams Parsons, Doug R. Smith, Philipp Angenendt, Rebecca J. Leary, B.K. Ahmed Rasheed, Hai Yan, Yuri Nikolsky, Parminder Mankoo, Nick Papadopoulos, Gregory J. Riggins, Rachel Karchin, Kenneth W. Kinzler, Gary L. Gallia, Jimmy Lin, Giovanni Parmigiani, I-Mei Siu, Hannah Carter, Suely Kazue Nagahashi Marie, James Hartigan
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes, determined the presence of amplifications and deletions using high-density oligon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc5d0f3162b33b9ce2f5f97f8071f1b
Autor:
Pasi A. Jänne, Mark A. Bittinger, Sushma Gurumurthy, Annapurna Venkatakrishnan, Christopher H. Hulton, Russell McSweeney, Oleg Schmidt-Kittler, Kwok-Kin Wong, Victoria M. Richon, David Jakubosky, Karin Jensen, Hongwei Zhou, Meghana M. Kulkarni, Jason Berglund, Robert E. Jones, David J. Wilson, Daniel Michaud, Jack Pollard, Christopher Winter, Jingxin Zhang, Jessie M. English, Parminder Mankoo, Nicole M. Sjoblom
Publikováno v:
Cancer Research. 75:1110-1110
Gastric cancer is the second leading cause of cancer deaths in the world. The genomics of gastric cancers is unique in that they harbor significantly more copy number alterations compared to point mutations, yet the functional importance of these gen