The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1.

Autor: Herrera Moro Chao D; Department of Medical Biochemistry, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Laboratory of Endocrinology, Department of Endocrinology and Metabolism, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Wang Y; Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands., Foppen E; Laboratory of Endocrinology, Department of Endocrinology and Metabolism, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Ottenhoff R; Department of Medical Biochemistry, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., van Roomen C; Department of Medical Biochemistry, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Parlevliet ET; Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands., van Eijk M; Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden, the Netherlands., Verhoek M; Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden, the Netherlands., Boot R; Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden, the Netherlands., Marques AR; Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden, the Netherlands., Scheij S; Department of Medical Biochemistry, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Mirzaian M; Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden, the Netherlands., Kooijman S; Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands., Jansen K; Laboratory of Endocrinology, Department of Endocrinology and Metabolism, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Wang D; Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.; Institute of Plant Protection, Chinese Academy of Agricultural Science, Beijing, China., Mergen C; Helmholtz Diabetes Center and German Center for Diabetes Research, Helmholtz Zentrum München, Neuherberg, Germany, and Division of Metabolic Diseases, Technische Universität München, Munich, Germany., Seeley RJ; Department of Surgery, University of Michigan, MI., Tschöp MH; Helmholtz Diabetes Center and German Center for Diabetes Research, Helmholtz Zentrum München, Neuherberg, Germany, and Division of Metabolic Diseases, Technische Universität München, Munich, Germany., Overkleeft H; Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden, the Netherlands., Rensen PCN; Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands., Kalsbeek A; Laboratory of Endocrinology, Department of Endocrinology and Metabolism, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.; Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands., Aerts JMFG; Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden, the Netherlands j.m.f.g.aerts@lic.leidenuniv.nl., Yi CX; Laboratory of Endocrinology, Department of Endocrinology and Metabolism, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Publikováno v: Diabetes [Diabetes] 2019 Dec; Vol. 68 (12), pp. 2223-2234. Date of Electronic Publication: 2019 Oct 02.

Inhibition of the central melanocortin system decreases brown adipose tissue activity.

Autor: Kooijman S; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands., Boon MR; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands., Parlevliet ET; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands Department of Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands., Geerling JJ; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands., van de Pol V; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands., Romijn JA; Department of Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands., Havekes LM; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands Netherlands Organization for Applied Scientific Research, Gaubius Laboratory, Leiden, The Netherlands., Meurs I; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands., Rensen PC; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: Journal of lipid research [J Lipid Res] 2014 Oct; Vol. 55 (10), pp. 2022-32. Date of Electronic Publication: 2014 Jul 12.

Sympathetic nervous system control of triglyceride metabolism: novel concepts derived from recent studies.

Autor: Geerling JJ; Departments of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands., Boon MR, Kooijman S, Parlevliet ET, Havekes LM, Romijn JA, Meurs IM, Rensen PC

Publikováno v: Journal of lipid research [J Lipid Res] 2014 Feb; Vol. 55 (2), pp. 180-9. Date of Electronic Publication: 2013 Nov 27.

GLP-1 receptor activation inhibits VLDL production and reverses hepatic steatosis by decreasing hepatic lipogenesis in high-fat-fed APOE*3-Leiden mice.

Autor: Parlevliet ET; Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands., Wang Y, Geerling JJ, Schröder-Van der Elst JP, Picha K, O'Neil K, Stojanovic-Susulic V, Ort T, Havekes LM, Romijn JA, Pijl H, Rensen PC

Publikováno v: PloS one [PLoS One] 2012; Vol. 7 (11), pp. e49152. Date of Electronic Publication: 2012 Nov 02.

Blocking dopamine D2 receptors by haloperidol curtails the beneficial impact of calorie restriction on the metabolic phenotype of high-fat diet induced obese mice.

Autor: de Leeuw van Weenen JE; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Centre, Leiden, The Netherlands., Auvinen HE, Parlevliet ET, Coomans CP, Schröder-van der Elst JP, Meijer OC, Pijl H

Publikováno v: Journal of neuroendocrinology [J Neuroendocrinol] 2011 Feb; Vol. 23 (2), pp. 158-67.