A Qualitative Modeling Approach for Whole Genome Prediction Using High-Throughput Toxicogenomics Data and Pathway-Based Validation.

Autor: Haider S; ScitoVation, Research Triangle Park, NC, United States., Black MB; ScitoVation, Research Triangle Park, NC, United States., Parks BB; ScitoVation, Research Triangle Park, NC, United States., Foley B; ScitoVation, Research Triangle Park, NC, United States., Wetmore BA; ScitoVation, Research Triangle Park, NC, United States., Andersen ME; ScitoVation, Research Triangle Park, NC, United States., Clewell RA; ScitoVation, Research Triangle Park, NC, United States., Mansouri K; ScitoVation, Research Triangle Park, NC, United States., McMullen PD; ScitoVation, Research Triangle Park, NC, United States.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2018 Oct 02; Vol. 9, pp. 1072. Date of Electronic Publication: 2018 Oct 02 (Print Publication: 2018).

A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway nodes.

Autor: Suzuki OT; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy at the University of North Carolina at Chapel Hill Chapel Hill, NC, USA., Frick A; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy at the University of North Carolina at Chapel Hill Chapel Hill, NC, USA., Parks BB; The Hamner Institutes for Health Sciences, Research Triangle Park NC, USA., Trask OJ Jr; The Hamner Institutes for Health Sciences, Research Triangle Park NC, USA., Butz N; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy at the University of North Carolina at Chapel Hill Chapel Hill, NC, USA., Steffy B; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy at the University of North Carolina at Chapel Hill Chapel Hill, NC, USA., Chan E; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy at the University of North Carolina at Chapel Hill Chapel Hill, NC, USA., Scoville DK; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy at the University of North Carolina at Chapel Hill Chapel Hill, NC, USA., Healy E; The Hamner Institutes for Health Sciences, Research Triangle Park NC, USA., Benton C; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy at the University of North Carolina at Chapel Hill Chapel Hill, NC, USA., McQuaid PE; Meredith College Raleigh, NC, USA., Thomas RS; The Hamner Institutes for Health Sciences, Research Triangle Park NC, USA., Wiltshire T; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy at the University of North Carolina at Chapel Hill Chapel Hill, NC, USA.

Publikováno v: Frontiers in genetics [Front Genet] 2014 Aug 29; Vol. 5, pp. 272. Date of Electronic Publication: 2014 Aug 29 (Print Publication: 2014).