Phosphorylation of Parkin at serine 65 is essential for its activation in vivo

Autor: Alan R. Prescott, Graeme Ball, Kyle Fears, Miratul M. K. Muqit, Pentti J. Tienari, Axel Knebel, Johanna Eerola-Rautio, Riccardo Brambilla, Sophie Burel, Lambert Montava-Garriga, Simon Philip Brooks, Odetta Antico, Anu Suomalainen, Ayse Ulusoy, Rachel Hills, Olga Corti, François Mouton-Liger, Eino Palin, Ian G. Ganley, Donato A. Di Monte, Kristin Balk, Jevgenia Tamjar, Thomas G. McWilliams, Laura Smith, François Singh, Stephen B. Dunnett, Risto Pohjolan-Pirhonen, Atul Kumar, Sidi Mohamed Hassoun, Erica Barini, Miko Valori

Publikováno v: Open Biology
'Open Biology ', vol: 8, pages: 180108-1-180108-18 (2018)
Open biology 8(11), 180108 (2018). doi:10.1098/rsob.180108
Open Biology, Vol 8, Iss 11 (2018)

Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture and in vitro studies have elaborated the PINK1-dependent regulation of Parkin and defined how this dyad orchestrates the elimination of damaged mitocho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7baefaa2863884eb308aad3466aa3ab2
http://europepmc.org/articles/PMC6282074

Phosphorylation of Parkin at serine 65 is essential for its activation in vivo .

Autor: McWilliams TG; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK thomas.mcwilliams@helsinki.fi.; Research Programs Unit, Molecular Neurology, University of Helsinki, 00290 Helsinki, Finland., Barini E; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Pohjolan-Pirhonen R; Research Programs Unit, Molecular Neurology, University of Helsinki, 00290 Helsinki, Finland.; Neuroscience Center, University of Helsinki, 00290 Helsinki, Finland.; Helsinki University Hospital, 00290 Helsinki, Finland., Brooks SP; The Brain Repair Group, Division of Neuroscience, School of Biosciences, Cardiff University, Wales CF10 3AX, UK., Singh F; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Burel S; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Balk K; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Kumar A; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Montava-Garriga L; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Prescott AR; Dundee Imaging Facility, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Hassoun SM; CNRS, Inserm, Paris, France., Mouton-Liger F; CNRS, Inserm, Paris, France., Ball G; Dundee Imaging Facility, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Hills R; The Brain Repair Group, Division of Neuroscience, School of Biosciences, Cardiff University, Wales CF10 3AX, UK., Knebel A; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Ulusoy A; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Di Monte DA; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany., Tamjar J; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Antico O; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Fears K; The Brain Repair Group, Division of Neuroscience, School of Biosciences, Cardiff University, Wales CF10 3AX, UK., Smith L; The Brain Repair Group, Division of Neuroscience, School of Biosciences, Cardiff University, Wales CF10 3AX, UK., Brambilla R; Neuroscience & Mental Health Institute, Neuroscience Division, School of Biosciences, Hadyn Ellis Building, Maindy Road, Cardiff CF24 4HQ, UK., Palin E; Research Programs Unit, Molecular Neurology, University of Helsinki, 00290 Helsinki, Finland.; Neuroscience Center, University of Helsinki, 00290 Helsinki, Finland.; Helsinki University Hospital, 00290 Helsinki, Finland., Valori M; Research Programs Unit, Molecular Neurology, University of Helsinki, 00290 Helsinki, Finland.; Neuroscience Center, University of Helsinki, 00290 Helsinki, Finland.; Helsinki University Hospital, 00290 Helsinki, Finland., Eerola-Rautio J; Research Programs Unit, Molecular Neurology, University of Helsinki, 00290 Helsinki, Finland.; Neuroscience Center, University of Helsinki, 00290 Helsinki, Finland.; Helsinki University Hospital, 00290 Helsinki, Finland.; Department of Neurology, Helsinki University Hospital, Haartmaninkatu 4, Helsinki, FI 00290, Finland., Tienari P; Research Programs Unit, Molecular Neurology, University of Helsinki, 00290 Helsinki, Finland.; Neuroscience Center, University of Helsinki, 00290 Helsinki, Finland.; Helsinki University Hospital, 00290 Helsinki, Finland., Corti O; CNRS, Inserm, Paris, France., Dunnett SB; The Brain Repair Group, Division of Neuroscience, School of Biosciences, Cardiff University, Wales CF10 3AX, UK., Ganley IG; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Suomalainen A; Research Programs Unit, Molecular Neurology, University of Helsinki, 00290 Helsinki, Finland.; Neuroscience Center, University of Helsinki, 00290 Helsinki, Finland.; Helsinki University Hospital, 00290 Helsinki, Finland., Muqit MMK; MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK m.muqit@dundee.ac.uk.; School of Medicine, University of Dundee, Dundee DD1 9SY, UK.

Publikováno v: Open biology [Open Biol] 2018 Nov 07; Vol. 8 (11). Date of Electronic Publication: 2018 Nov 07.