Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Parker W, de Waal"'
Autor:
Pelin Ayaz, Agatha Lyczek, YiTing Paung, Victoria R. Mingione, Roxana E. Iacob, Parker W. de Waal, John R. Engen, Markus A. Seeliger, Yibing Shan, David E. Shaw
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Atomic-level descriptions of protein–small molecule binding processes that involve a large conformational change of the protein have been elusive. Here, the authors report unguided molecular dynamics simulations of such a process—Abl kinase bindi
Externí odkaz:
https://doaj.org/article/e9aae3578aa946d8ba5c8a7f929b7cf9
Autor:
Youwen Zhuang, Heng Liu, X. Edward Zhou, Ravi Kumar Verma, Parker W. de Waal, Wonjo Jang, Ting-Hai Xu, Lei Wang, Xing Meng, Gongpu Zhao, Yanyong Kang, Karsten Melcher, Hao Fan, Nevin A. Lambert, H. Eric Xu, Cheng Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Formylpeptide receptors (FPRs) are a class of chemotactic G protein-coupled receptors (GPCRs) that recognize pathogen- and host-derived formylpeptides. Here the authors report the 3.17 Å cryo-EM structure of the human FPR2-Gi signaling complex with
Externí odkaz:
https://doaj.org/article/3c877c5e058b47a68a52db49730981f1
Autor:
Parker W de Waal, Jingjing Shi, Erli You, Xiaoxi Wang, Karsten Melcher, Yi Jiang, H Eric Xu, Bradley M Dickson
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 4, p e1007394 (2020)
The development of novel analgesics with improved safety profiles to combat the opioid epidemic represents a central question to G protein coupled receptor structural biology and pharmacology: What chemical features dictate G protein or β-arrestin s
Externí odkaz:
https://doaj.org/article/635dacf284454c0382637012e3d7ad7b
Autor:
Ravi Kumar Verma, Lei Wang, Heng Liu, Hao Fan, Parker W. de Waal, X. Edward Zhou, Gongpu Zhao, Karsten Melcher, H. Eric Xu, Xing Meng, Youwen Zhuang, Wonjo Jang, Yanyong Kang, Cheng Zhang, Nevin A. Lambert, Ting-Hai Xu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Formylpeptide receptors (FPRs) as G protein-coupled receptors (GPCRs) can recognize formylpeptides derived from pathogens or host cells to function in host defense and cell clearance. In addition, FPRs, especially FPR2, can also recognize other ligan
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e108607 (2014)
Cytochrome P450 enzymes (CYPs) represent an important enzyme superfamily involved in metabolism of many endogenous and exogenous small molecules. CYP2D6 is responsible for ∼ 15% of CYP-mediated drug metabolism and exhibits large phenotypic diversit
Externí odkaz:
https://doaj.org/article/4595aec10da04a5e9175488882c97e68
Autor:
Erli You, Parker W. de Waal, Karsten Melcher, H. Eric Xu, Jingjing Shi, Xiaoxi Wang, Bradley M. Dickson, Yi Jiang
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 16, Iss 4, p e1007394 (2020)
PLoS Computational Biology, Vol 16, Iss 4, p e1007394 (2020)
The development of novel analgesics with improved safety profiles to combat the opioid epidemic represents a central question to G protein coupled receptor structural biology and pharmacology: What chemical features dictate G protein or β-arrestin s
Autor:
H. Eric Xu, Lu Yang, Petr Popov, Raymond C. Stevens, Fei Xu, Mengchen Pu, Yuanzheng He, Yuxiang Chen, Kelly Suino-Powell, Shaowei Dong, Kaleeckal G. Harikumar, Yiran Wu, Parker W. de Waal, Laurence J. Miller, Zachary J. DeBruine, Yu Guo, Karsten Melcher, Vsevolod Katritch, Wenqing Shui, Gye Won Han, Shifan Yang, Saheem A. Zaidi, Suwen Zhao, Bingjie Zhang, Ting-Hai Xu
Publikováno v:
Nature. 560:666-670
Frizzled receptors (FZDs) are class-F G-protein-coupled receptors (GPCRs) that function in Wnt signalling and are essential for developing and adult organisms1,2. As central mediators in this complex signalling pathway, FZDs serve as gatekeeping prot
Autor:
Bo Liu, Karsten Melcher, Xiaoxi Wang, Yechun Xu, Jiang Wang, Antao Dai, Ping Liu, Parker W. de Waal, Ming-Wei Wang, Xiaoqing Cai, Yanting Yin, X. Edward Zhou, Yu Zhou, H. Eric Xu, Wanchao Yin, Yi Jiang, Dehua Yang, Hong Liu, Martin Caffrey, Chia-Ying Huang, Meitian Wang
Publikováno v:
Cell Discovery, Vol 4, Iss 1, Pp 1-13 (2018)
5-hydroxytryptamine (5-HT, also known as serotonin) regulates many physiological processes through the 5-HT receptor family. Here we report the crystal structure of 5-HT1B subtype receptor (5-HT1BR) bound to the psychotropic serotonin receptor invers
Autor:
Karsten Melcher, Lihua Zhao, Parker W. de Waal, Xiaoqing Cai, Yuanzheng He, Ming-Wei Wang, Dehua Yang, H. Eric Xu, Yi Jiang, Yanting Yin
Publikováno v:
Journal of Biological Chemistry. 292:9865-9881
The glucagon receptor (GCGR) belongs to the secretin-like (class B) family of G protein-coupled receptors (GPCRs) and is activated by the peptide hormone glucagon. The structures of an activated class B GPCR have remained unsolved, preventing a mecha
Autor:
H. Eric Xu, Qingya Shen, Denise Wootten, Yan Zhang, Karsten Melcher, X. Edward Zhou, Shanshan Ma, Parker W. de Waal, Lihua Zhao, Chuntao Li, Chunyou Mao, Peng Bi, Yi Jiang, D.-D. Shen, Patrick M. Sexton, Ming-Wei Wang
Publikováno v:
Molecular Cell. 77:669-680.e4
Corticotropin-releasing factor (CRF) and the three related peptides urocortins 1-3 (UCN1-UCN3) are endocrine hormones that control the stress responses by activating CRF1R and CRF2R, two members of class B G-protein-coupled receptors (GPCRs). Here, w