Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Parker Mathers"'
Autor:
Guoxin Wu, Kristin R. Wildsmith, Andrew Stamford, Kevin E. Yarasheski, Matthew E. Kennedy, David B. Gilberto, Yuriy Pyatkivskyy, Randall J. Bateman, Daniel J. Holder, Mary J. Savage, Robert Chott, Debra A. McLoughlin, Justyna Dobrowolska, Bruce W. Patterson, Mandy Dancho, Tom Kasten, Vitaliy Ovod, Parker Mathers, Maria S. Michener, Christina Lennox, Brad E. Smith
Publikováno v:
Journal of Neuroscience. 34:8336-8346
BACE, a β-secretase, is an attractive potential disease-modifying therapeutic strategy for Alzheimer's disease (AD) as it results directly in the decrease of amyloid precursor protein (APP) processing through the β-secretase pathway and a lowering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8226a5d06346bb6b6f0282836004a342
https://doi.org/10.1523/jneurosci.0540-14.2014
https://doi.org/10.1523/jneurosci.0540-14.2014
Autor:
Eric A. Price, Gene G. Kinney, Randall J. Bateman, Maria S. Michener, Marie A. Holahan, Parker Mathers, Adam J. Simon, Kristin R. Wildsmith, Guoxin Wu, David B. Gilberto, Kevin E. Yarasheski, Mark S. Shearman, Jennifer X. Wang, Jacquelynn J. Cook
Publikováno v:
The Journal of Neuroscience. 30:6743-6750
The accumulation of amyloid β (Aβ) in Alzheimer's disease is caused by an imbalance of production and clearance, which leads to increased soluble Aβ species and extracellular plaque formation in the brain. Multiple Aβ-lowering therapies are curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d9aa001455fd8acc1992eb9b9c5fd9a
https://doi.org/10.1523/jneurosci.1381-10.2010
https://doi.org/10.1523/jneurosci.1381-10.2010
Autor:
Natesan Murugesan, Zhengxiang Gu, Philip D. Stein, Sharon Bisaha, Steve Spergel, Ravi Girotra, Ving G. Lee, John Lloyd, Raj N. Misra, Joan Schmidt, Arvind Mathur, Leslie Stratton, Yolanda F. Kelly, Eileen Bird, Tom Waldron, Eddie C.-K. Liu, Rongan Zhang, Helen Lee, Randy Serafino, Benoni Abboa-Offei, Parker Mathers, Mary Giancarli, Andrea Ann Seymour, Maria L. Webb, Suzanne Moreland, Joel C. Barrish, John T. Hunt
Publikováno v:
Journal of Medicinal Chemistry. 41:5198-5218
Substitution at the ortho position of N-(3,4-dimethyl-5-isoxazolyl) benzenesulfonamide led to the identification of the biphenylsulfonamides as a novel series of endothelin-A (ETA) selective antagonists. Appropriate substitutions on the pendant pheny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13b9d120282a5b804e9ffa082e32bd29
https://doi.org/10.1021/jm970872k
https://doi.org/10.1021/jm970872k
Autor:
Matthew E. Kennedy, Brad Smith, Guoxin Wu, Kevin E. Yarasheski, Christina Lennox, Randall J. Bateman, Justyna Dobrowolska, Dan Holder, Andrew Stamford, Yuriy Pyatkivskyy, Kristin R. Wildsmith, Mandy Dancho, Tom Kasten, Maria S. Michener, Vitaliy Ovod, Parker Mathers, Debra A. McLoughlin, Bruce W. Patterson, David B. Gilberto, Robert Chott, Mary J. Savage
Publikováno v:
Alzheimer's & Dementia. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a769fe1ed29756c6d00505e16916ef96
https://doi.org/10.1016/j.jalz.2013.04.111
https://doi.org/10.1016/j.jalz.2013.04.111