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Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice

Autor: Rosello, M, Kaforou, M, Frontini, A, Okolo, A, Chan, Y-W, Nikolopoulou, E, Millership, S, Fenech, ME, MacIntyre, D, Turner, JO, Moore, JD, Blackburn, E, Gullick, WJ, Cinti, S, Montana, G, Parker, MG, Christian, M

Publikováno v: AJP: Endocrinology and Metabolism; Vol 306
American Journal of Physiology-Endocrinology and Metabolism

Brown adipocytes dissipate energy, whereas white adipocytes are an energy storage site. We explored the plasticity of different white adipose tissue depots in acquiring a brown phenotype by cold exposure. By comparing cold-induced genes in white fat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::68755ddbe89782fa3b8954e3d726c64c

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Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential

Autor: Nikolopoulou, E, Papacleovoulou, G, Jean-Alphonse, F, Grimaldi, G, Parker, MG, Hanyaloglu, AC, Christian, M

Publikováno v: Journal of Lipid Research
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2014, 55 (12), pp.2479-2490. ⟨10.1194/jlr.M049551⟩

Arachidonic acid (AA) is a major PUFA that has been implicated in the regulation of adipogenesis. We examined the effect of a short exposure to AA at different stages of 3T3-L1 adipocyte differentiation. AA caused the upregulation of fatty acid bindi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ba392e09d366edc477e42944be3e8fcb
https://hal.archives-ouvertes.fr/hal-03117154

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RIP140 represses the 'Brown-in-White' adipocyte program including a futile cycle of triacyclglycerol breakdown and synthesis

Autor: Kiskinis, E, Chatzeli, L, Curry, E, Kaforou, M, Frontini, A, Cinti, S, Montana, G, Parker, MG, Christian, M

Publikováno v: Molecular Endocrinology
Molecular Endocrinology; Vol 28

Receptor-interacting protein 140 (RIP140) is a corepressor of nuclear receptors that is highly expressed in adipose tissues. We investigated the role of RIP140 in conditionally immortal preadipocyte cell lines prepared from white or brown fat depots.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::94193d4edbdf8b4877df44bda2f93aba
http://wrap.warwick.ac.uk/63874/1/WRAP_me%2E2013-1254.pdf

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Action of ?pure? antiestrogens in inhibiting estrogen receptor action

Autor: Parker Mg

Publikováno v: Breast Cancer Research and Treatment. 26:131-137

The mechanism of action of the pure antiestrogens ICI 164384 and ICI 182780 has been investigated. Both antagonists are steroidal antiestrogens with 7 alpha-alkylamide side-chains. The antiestrogens reduce the cellular content of the estrogen recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4eeb8268804cb61ffceaefe0506c04b
https://doi.org/10.1007/bf00689686

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Kidney allograft biopsy: timing to complications

Autor: McKenna J, Parker Mg, Recupero P, Yablon Z, John P. Vella

Publikováno v: Clinical nephrology. 74(1)

Background: Clinical Practice guidelines recommend that patients be observed overnight after kidney biopsy based upon data that 1/3 of bleeding complications occur 12 hours post-procedure. Retrospective studies of same day discharge after kidney allo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acdbc68d2463670f9889e39ffc444135
https://pubmed.ncbi.nlm.nih.gov/20557865

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Structure and Function of Estrogen Receptors

Autor: Parker Mg

Publisher Summary This chapter examines the structure and function of estrogen receptors. Steroid hormones, retinoids, thyroid hormone, and other small lipophilic hormones elicit numerous effects in mammalian cells and tissues by binding to receptors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1cf256722569fab1134ac79977e2eb6c
https://doi.org/10.1016/s0083-6729(08)61041-9

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Mechanisms of action of steroid receptors in the regulation of gene transcription

Autor: Parker Mg

Publikováno v: Journal of reproduction and fertility. 88(2)

Steroid hormones regulate rates of transcription of certain genes by binding as a hormone-receptor complex to specific DNA sequences termed steroid-response elements. These elements consist of inverted repeats of the sequence TGTTCT for glucocorticoi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bfcfdde06acb356e1a4347ac4a26f1b
https://pubmed.ncbi.nlm.nih.gov/2325027

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