Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Parker Kneis"'
Autor:
Daniel M. Virga, Stevie Hamilton, Bertha Osei, Abigail Morgan, Parker Kneis, Emiliano Zamponi, Natalie J. Park, Victoria L. Hewitt, David Zhang, Kevin C. Gonzalez, Fiona M. Russell, D. Grahame Hardie, Julien Prudent, Erik Bloss, Attila Losonczy, Franck Polleux, Tommy L. Lewis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Neuronal mitochondria play important roles beyond ATP generation, including Ca2+ uptake, and therefore have instructive roles in synaptic function and neuronal response properties. Mitochondrial morphology differs significantly between the a
Externí odkaz:
https://doaj.org/article/4622b875797a4a148a830a6b459942d0
Autor:
Hongyang Xu, Shylesh Bhaskaran, Katarzyna M. Piekarz, Rojina Ranjit, Jan Bian, Parker Kneis, Aubrey Ellis, Suyesha Bhandari, Heather C. Rice, Holly Van Remmen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Emerging evidence suggests that patients with Alzheimer’s disease (AD) may show accelerated sarcopenia phenotypes. To investigate whether pathological changes associated with neuronal death and cognitive dysfunction also occur in peripheral motor n
Externí odkaz:
https://doaj.org/article/33029d926d524910bcfb714ac428edef
Autor:
Bumsoo Ahn, Nataliya Smith, Debra Saunders, Rojina Ranjit, Parker Kneis, Rheal A. Towner, Holly Van Remmen
Publikováno v:
Redox Biology, Vol 26, Iss , Pp - (2019)
Mitochondrial dysfunction, reactive oxygen species (ROS) and oxidative damage have been implicated to play a causative role in age-related skeletal muscle atrophy and weakness (i.e. sarcopenia). Mice lacking the superoxide scavenger CuZnSOD (Sod1−/
Externí odkaz:
https://doaj.org/article/2438b08b2bb84681bebc429a667b350b
Autor:
Bumsoo Ahn, Parker Kneis, Arlan Richardson, Michael Kinter, Chase A. Brown, Benjamin F. Miller, Jacob L. Brown, Katarzyna M. Piekarz, Gavin Pharaoh, Rizwan Qaisar, Rojina Ranjit, Jan Bian, Holly Van Remmen, Fredrick F. Peelor, Marcus M. Lawrence
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle
Background Cancer is associated with muscle atrophy (cancer cachexia) that is linked to up to 40% of cancer‐related deaths. Oxidative stress is a critical player in the induction and progression of age‐related loss of muscle mass and weakness (sa
Autor:
Bumsoo Ahn, Rojina Ranjit, Parker Kneis, Hongyang Xu, Katarzyna M. Piekarz, Willard M. Freeman, Michael Kinter, Arlan Richardson, Qitao Ran, Susan V. Brooks, Holly Van Remmen
Publikováno v:
Aging cell. 21(3)
Age-related muscle atrophy and weakness, or sarcopenia, are significant contributors to compromised health and quality of life in the elderly. While the mechanisms driving this pathology are not fully defined, reactive oxygen species, neuromuscular j
Autor:
Qitao Ran, Willard M. Freeman, Michael Kinter, Holly Van Remmen, Parker Kneis, Jan Bian, Kavithalakshmi Sataranatarajan, Niran Hadad, Peter S. Rabinovitch, Constantin Georgescu, Jacob L. Brown, Jonathan D. Wren, Rojina Ranjit, Arlan Richardson, Gavin Pharaoh
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Defects in neuromuscular innervation contribute significantly to the age-related decline in muscle mass and function (sarcopenia). Our previous studies demonstrated that denervation induces muscle mitochondrial hydroperoxide production (H2O2 and lipi
Autor:
Gavin, Pharaoh, Jacob L, Brown, Kavithalakshmi, Sataranatarajan, Parker, Kneis, Jan, Bian, Rojina, Ranjit, Niran, Hadad, Constantin, Georgescu, Peter, Rabinovitch, Qitao, Ran, Jonathan D, Wren, Willard, Freeman, Michael, Kinter, Arlan, Richardson, Holly, Van Remmen
Publikováno v:
Scientific Reports
Defects in neuromuscular innervation contribute significantly to the age-related decline in muscle mass and function (sarcopenia). Our previous studies demonstrated that denervation induces muscle mitochondrial hydroperoxide production (H2O2 and lipi
Autor:
Debra Saunders, Nataliya Smith, Rheal A. Towner, Holly Van Remmen, Parker Kneis, Bumsoo Ahn, Rojina Ranjit
Publikováno v:
Redox Biology
Redox Biology, Vol 26, Iss, Pp-(2019)
Redox Biology, Vol 26, Iss, Pp-(2019)
Mitochondrial dysfunction, reactive oxygen species (ROS) and oxidative damage have been implicated to play a causative role in age-related skeletal muscle atrophy and weakness (i.e. sarcopenia). Mice lacking the superoxide scavenger CuZnSOD (Sod1-/-)