Single cell and spatial transcriptomics highlight the interaction of club-like cells with immunosuppressive myeloid cells in prostate cancer.

Autor: Kiviaho A; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland., Eerola SK; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland., Kallio HML; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland., Andersen MK; Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Surgery, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Hoikka M; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland., Tiihonen AM; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland., Salonen I; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland., Spotbeen X; Laboratory of Lipid Metabolism and Cancer, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium., Giesen A; Department of Urology, University Hospitals Leuven, Leuven, Belgium.; Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Parker CTA; University College London Cancer Institute, London, UK., Taavitsainen S; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland., Hantula O; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland., Marttinen M; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland.; European Molecular Biology Laboratory, Structural and Computational Biology Unit, Heidelberg, Germany.; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany., Hermelo I; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland., Ismail M; University College London Cancer Institute, London, UK., Midtbust E; Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Surgery, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Wess M; Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Surgery, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Devlies W; Department of Urology, University Hospitals Leuven, Leuven, Belgium.; Molecular Endocrinology Laboratory, Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium., Sharma A; Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Krossa S; Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.; Central staff, St. Olavs Hospital HF, 7006, Trondheim, Norway., Häkkinen T; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland., Afyounian E; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland., Vandereyken K; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium.; Laboratory of Reproductive Genomics, Department of Human Genetics, KU Leuven, Leuven, Belgium., Kint S; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium.; Laboratory of Reproductive Genomics, Department of Human Genetics, KU Leuven, Leuven, Belgium., Kesseli J; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland., Tolonen T; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland.; Department of Pathology, Fimlab Laboratories, Ltd, Tampere University Hospital, Tampere, Finland., Tammela TLJ; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Urology, Tampere University Hospital, Tampere, Finland., Viset T; Department of Pathology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway., Størkersen Ø; Department of Pathology, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway., Giskeødegård GF; Clinic of Surgery, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.; Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Rye MB; Clinic of Surgery, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Murtola T; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland., Erickson A; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; ICAN-Digital Precision Cancer Medicine Flagship, Helsinki, Finland.; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Latonen L; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Bova GS; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland., Mills IG; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.; Patrick G Johnston Centre for Cancer Research, Queen's University of Belfast, Belfast, UK., Joniau S; Department of Urology, University Hospitals Leuven, Leuven, Belgium.; Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Swinnen JV; Laboratory of Lipid Metabolism and Cancer, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium., Voet T; KU Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium.; Laboratory of Reproductive Genomics, Department of Human Genetics, KU Leuven, Leuven, Belgium., Mirtti T; Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; ICAN-Digital Precision Cancer Medicine Flagship, Helsinki, Finland.; Department of Pathology, University of Helsinki & Helsinki University Hospital, Helsinki, Finland., Attard G; University College London Cancer Institute, London, UK.; University College London Hospitals, London, UK., Claessens F; Molecular Endocrinology Laboratory, Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium., Visakorpi T; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland.; Fimlab Laboratories, Ltd, Tampere University Hospital, Tampere, Finland., Rautajoki KJ; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland., Tessem MB; Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Surgery, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Urbanucci A; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. alfonso.urbanucci@tuni.fi.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland. alfonso.urbanucci@tuni.fi.; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. alfonso.urbanucci@tuni.fi., Nykter M; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. matti.nykter@tuni.fi.; Prostate Cancer Research Center, Tampere University and TAYS Cancer Center, Tampere, Finland. matti.nykter@tuni.fi.

Publikováno v: Nature communications [Nat Commun] 2024 Nov 16; Vol. 15 (1), pp. 9949. Date of Electronic Publication: 2024 Nov 16.