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Akademický článek

Immunotoxicity of zinc oxide nanoparticles with different size and electrostatic charge

Autor: Kim CS, Nguyen HD, Ignacio RM, Kim JH, Cho HC, Maeng EH, Kim YR, Kim MK, Park BK, Kim SK

Publikováno v: International Journal of Nanomedicine, Vol 2014, Iss Supplement 2, Pp 195-205 (2014)

Cheol-Su Kim,1,* Hai-Duong Nguyen,1,* Rosa Mistica Ignacio,2 Jae-Hyun Kim,1 Hyeon-Cheol Cho,1 Eun Ho Maeng,3 Yu-Ri Kim,4 Meyoung-Kon Kim,4 Bae-Keun Park,5 Soo-Ki Kim1,5 1Department of Microbiology, Wonju College of Medicine, Yonsei University, Wonju-

Externí odkaz: https://doaj.org/article/52404eb834074945a4fffcd5e72442e6

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The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer

Autor: Evans, JP, Winiarski, BK, Sutton, PA, Jones, RP, Ressel, L, Duckworth, CA, Pritchard, DM, Lin, ZX, Vicky, FL, Tweedle, EM, Costello, E, Goldring, CE, Copple, IM, Park, BK, Palmer, DH, Kitteringham, NR

Publikováno v: Oncotarget

© Evans et al. Nrf2 is a transcription factor that regulates cellular stress response and irinotecan-metabolising pathways. Its aberrant activity has been reported in a number of cancers, although relatively few studies have explored a role for Nrf2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::c5a0f3d5005d2d5f8d85b80301049a22
http://livrepository.liverpool.ac.uk/3024449/1/25497-1005819-3-PB.pdf

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Test systems in Drug Discovery for hazard identification and risk assessment of human Drug-Induced Liver Injury

Autor: Weaver, RJ, Betts, C, Blomme, EAG, Gerets, HHJ, Gjervig Jensen, K, Hewitt, PG, Juhila, S, Labbe, G, Liguori, MJ, Mesens, N, Ogese, MO, Persson, M, Snoeys, J, Stevens, JL, Walker, T, Park, BK

Publikováno v: Expert opinion on drug metabolism & toxicology

Introduction The liver is an important target for drug-induced toxicities. Early detection of hepatotoxic drugs requires use of well-characterized test systems, yet current knowledge, gaps and limitations of tests employed remains an important issue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::37f47d10edd3d3971facceffb220ca8f

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Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

Autor: Lauschke, VM, Vorrink, SU, Moro, SML, Rezayee, F, Nordling, A, Hendriks, DFG, Bell, CC, Sison-Young, R, Park, BK, Goldring, CE, Ellis, E, Johansson, I, Mkrtchian, S, Andersson, TB, Ingelman-Sundberg, M

Publikováno v: HEPATOLOGY

Hepatocytes are dynamic cells that, upon injury, can alternate between nondividing differentiated and dedifferentiated proliferating states in vivo . However, in two‐dimensional cultures, primary human hepatocytes (PHHs) rapidly dedifferentiate, re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::81aad76cea98d7954ea6bdc8c5f9b00d
http://livrepository.liverpool.ac.uk/3006888/1/miRNA_manuscript_240716_flat_changesaccepted.docx

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Co-precipitation of DEAE-dextran coated SPIONs: how synthesis conditions affect particle properties, stem cell labelling and MR contrast

Autor: Barrow, M, Taylor, A, García Carrión, J, Mandal, P, Park, BK, Poptani, H, Murray, P, Rosseinsky, MJ, Adams, DJ

Publikováno v: Contrast media & molecular imaging

Superparamagnetic iron oxide nanoparticles (SPIONs) are widely used as contrast agents for stem cell tracking using magnetic resonance imaging (MRI). The total mass of iron oxide that can be internalised into cells without altering their viability or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::ca395605a896ef8fac370de1c6f216e2

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Preventing Plasmon Coupling between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labeled Stem Cells in Vivo

Autor: Comenge, J, Fragueiro, O, Sharkey, J, Taylor, A, Held, M, Burton, NC, Park, BK, Wilm, B, Murray, P, Brust, M, Lévy, R

Publikováno v: ACS Nano

© 2016 American Chemical Society.Gold nanorods are excellent contrast agents for imaging technologies which rely on near-infrared absorption such as photoacoustic imaging. For cell tracking applications, the cells of interest are labeled with the co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::23aa0d9be2579e3bae57306097479a66
http://livrepository.liverpool.ac.uk/3001829/1/Comenge_ACSNano_MS_resubmission.pdf

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The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein–Barr virus-positive NK/T-cell lymphoma by Akt down-regulation

Autor: Li Yc, Park Bk, Chu-Wan Kim, Kim Yn, Yun-Seok Jeon, Kim Ya, Jhingook Kim, Jihye Paik, Kim Ky, Park Ch

Publikováno v: The Journal of Pathology. 213:170-179

NK/T-cell lymphoma (NKTL) is strongly associated with latent Epstein-Barr virus (EBV) infection. Recently, latent membrane protein 1 (LMP1), an EBV oncoprotein, was reported to activate the phosphatidylinositol-3 kinase (PI3K)/Akt pathway for cell su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d76eba46324e1ca95b07a8b82db8e3d
https://doi.org/10.1002/path.2219

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Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome

Autor: Eakins, R, Walsh, J, Randle, LE, Jenkins, RE, Schuppe-Koistinen, I, Rowe, C, Starkey Lewis, P, Vasieva, O, Prats, N, Brillant, N, Auli, M, Bayliss, M, Webb, S, Rees, JA, Kitteringham, NR, Goldring, CE, Park, BK

Publikováno v: Scientific Reports.

Acetaminophen overdose is the leading cause of acute liver failure. One dose of 10-15 g causes severe liver damage in humans, whereas repeated exposure to acetaminophen in humans and animal models results in autoprotection. Insight of this process is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::dcd5a464ad6968739af8bf39dca4b387

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