Gut-derived ammonia contributes to alcohol-related fatty liver development via facilitating ethanol metabolism and provoking ATF4-dependent de novo lipogenesis activation

Autor: Song, Qing, Hwang, Chueh-Lung, Li, Yanhui, Wang, Jun, Park, Jooman, Lee, Samuel M., Sun, Zhaoli, Sun, Jun, Xia, Yinglin, Nieto, Natalia, Cordoba-Chacon, Jose, Jiang, Yuwei, Dou, Xiaobing, Song, Zhenyuan

Publikováno v: In Metabolism February 2024 151

Genetically prolonged beige fat in male mice confers long-lasting metabolic health.

Autor: Wu, Ruifan, Park, Jooman, Qian, Yanyu, Shi, Zuoxiao, Hu, Ruoci, Yuan, Yexian, Xiong, Shaolei, Wang, Zilai, Yan, Gege, Ong, Sang-Ging, Song, Qing, Song, Zhenyuan, Mahmoud, Abeer M., Xu, Pingwen, He, Congcong, Arpke, Robert W., Kyba, Michael, Shu, Gang, Jiang, Qingyan, Jiang, Yuwei

Publikováno v: Nature Communications; 5/12/2023, Vol. 14, p1-17, 17p

Macrophage-derived chemokine CCL22 establishes local LN-mediated adaptive thermogenesis and energy expenditure.

Autor: Yuan Y; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.; Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China., Hu R; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA., Park J; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA., Xiong S; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA., Wang Z; Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA., Qian Y; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA., Shi Z; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA., Wu R; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.; Guangdong Laboratory of Lingnan Modern Agriculture, Guangdong Province Key Laboratory of Animal Nutritional Regulation and National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China., Han Z; Department of Pharmacology and Regenerative Medicine, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA., Ong SG; Department of Pharmacology and Regenerative Medicine, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.; Division of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA., Lin S; Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA., Varady KA; Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60612, USA., Xu P; Division of Endocrinology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA., Berry DC; Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA., Shu G; Guangdong Laboratory of Lingnan Modern Agriculture, Guangdong Province Key Laboratory of Animal Nutritional Regulation and National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China., Jiang Y; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.; Division of Endocrinology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

Publikováno v: Science advances [Sci Adv] 2024 Jun 28; Vol. 10 (26), pp. eadn5229. Date of Electronic Publication: 2024 Jun 26.

P21-activated kinase-1 signaling is required to preserve adipose tissue homeostasis and cardiac function.

Autor: Munoz M; Divison of Endocrinology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA., Solis C; Department of Health, Nutrition & Food Sciences, Florida State University, Tallahassee, FL, USA., McCann M; Department of Ophthalmology & Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA., Park J; Department of Physiology & Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA., Rafael-Clyke K; Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA., Chowdhury SAK; Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA., Jiang Y; Department of Physiology & Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA., Rosas PC; Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA. prosas@uic.edu.

Publikováno v: Molecular and cellular biochemistry [Mol Cell Biochem] 2024 Mar 02. Date of Electronic Publication: 2024 Mar 02.

mTORC1 inhibition uncouples lipolysis and thermogenesis in white adipose tissue to contribute to alcoholic liver disease.

Autor: Song Q; Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA., Chen Y; Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA., Ding Q; College of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China., Griffiths A; Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA., Liu L; Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois, USA., Park J; Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois, USA., Liew CW; Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois, USA., Nieto N; Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, USA., Li S; College of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China., Dou X; College of Life Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China., Jiang Y; Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois, USA., Song Z; Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.

Publikováno v: Hepatology communications [Hepatol Commun] 2023 Feb 09; Vol. 7 (3), pp. e0059. Date of Electronic Publication: 2023 Feb 09 (Print Publication: 2023).