Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Paritha, Arumugam"'
Autor:
Paritha Arumugam, Brenna C. Carey, Kathryn A. Wikenheiser-Brokamp, Jeffrey Krischer, Matthew Wessendarp, Kenjiro Shima, Claudia Chalk, Jennifer Stock, Yan Ma, Diane Black, Michelle Imbrogno, Margaret Collins, Dan Justin Kalenda Yombo, Haripriya Sakthivel, Takuji Suzuki, Carolyn Lutzko, Jose A. Cancelas, Michelle Adams, Elizabeth Hoskins, Dawn Lowe-Daniels, Lilith Reeves, Anne Kaiser, Bruce C. Trapnell
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101213- (2024)
Pulmonary macrophage transplantation (PMT) is a gene and cell transplantation approach in development as therapy for hereditary pulmonary alveolar proteinosis (hPAP), a surfactant accumulation disorder caused by mutations in CSF2RA/B (and murine homo
Externí odkaz:
https://doaj.org/article/ef79e141ea884151aa5844042636462d
Autor:
Cormac McCarthy, Elinor Lee, James P. Bridges, Anthony Sallese, Takuji Suzuki, Jason C. Woods, Brian J. Bartholmai, Tisha Wang, Claudia Chalk, Brenna C. Carey, Paritha Arumugam, Kenjiro Shima, Elizabeth J. Tarling, Bruce C. Trapnell
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Pulmonary alveolar proteinosis (PAP) is associated with defective macrophage clearance of surfactant. Here, the authors show that patients with PAP have altered cholesterol-to-phospholipid ratio in their surfactant, and that more importantly, statin
Externí odkaz:
https://doaj.org/article/d8cc338509bd449f91fc403c8ee500b8
Autor:
Kenjiro, Shima, Paritha, Arumugam, Anthony, Sallese, Yuko, Horio, Yan, Ma, Cole, Trapnell, Matthew, Wessendarp, Claudia, Chalk, Cormac, McCarthy, Brenna C, Carey, Bruce C, Trapnell, Takuji, Suzuki
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder caused by recessive mutations in GM-CSF receptor subunit α/β genes (CSF2RA/CSF2RB, respectively) characterized by impaired GM-CSF-dependent surfactant clearance by alveolar macroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f7cfcccf1161543e42f29b5d5dfdf47c
https://pubmed.ncbi.nlm.nih.gov/35043685
https://pubmed.ncbi.nlm.nih.gov/35043685
Autor:
Kenjiro Shima, Paritha Arumugam, Anthony Sallese, Yuko Horio, Yan Ma, Cole Trapnell, Matthew Wessendarp, Claudia Chalk, Cormac McCarthy, Brenna C. Carey, Bruce C. Trapnell, Takuji Suzuki
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 322:L438-L448
Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder caused by recessive mutations in GM-CSF receptor subunit α/β genes ( CSF2RA/ CSF2RB, respectively) characterized by impaired GM-CSF-dependent surfactant clearance by alveolar macro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::009cd4678bdfb38cb62484d1b8cbbd21
https://doi.org/10.1152/ajplung.00175.2021
https://doi.org/10.1152/ajplung.00175.2021
Autor:
Lindsey-Romick Rosendale, Marie Dominique Filippi, Miki Watanabe-Chailland, Serena Liu, Kenjiro Shima, Brenna Carey, Rajesh K Kasam, Paritha Arumugam, M. Wessendarp, Claudia Chalk, Traci E. Stankiewicz, Y. Ma
Publikováno v:
Mitochondrion
Granulocyte-macrophage colony-stimulating factor (GM-CSF) exerts pleiotropic effects on macrophages and is required for self-renewal but the mechanisms responsible are unknown. Using mouse models with disrupted GM-CSF signaling, we show GM-CSF is cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d330846ded0cf079c33baed828cc90
https://doi.org/10.1016/j.mito.2021.10.009
https://doi.org/10.1016/j.mito.2021.10.009
Autor:
Matthew J. Flick, Bennett D. Elzey, Silvio Antoniak, Yi Yang, Paritha Arumugam, Emily E White, Stephen F. Konieczny, Nigel Mackman, Gregory M. Cresswell, Patrick G. Schweickert, Timothy L. Ratliff
Publikováno v:
J Thromb Haemost
Essentials Elimination of PDAC tumor cell PAR1 increased cytotoxic T cells and reduced tumor macrophages. PAR1KO PDAC cells are preferentially eliminated from growing tumors. Thrombin-PAR1 signaling in PDAC tumor cells drives an immunosuppressive gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eafd44a7658dc86bc27c866227b9dafa
https://doi.org/10.1111/jth.15115
https://doi.org/10.1111/jth.15115
Autor:
Arun Pradhan, Samriddhi Shukla, Paritha Arumugam, Vladimir V. Kalinichenko, Markaisa Black, Tanya V. Kalin, Vladimir Ustiyan, David Milewski
Publikováno v:
Molecular Biology of the Cell
Forkhead box M1 (FOXM1), a nuclear transcription factor that activates cell cycle regulatory genes, is highly expressed in a majority of human cancers. The function of FOXM1 independent of nuclear transcription is unknown. In the present study, we fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2090bb076ef8a8f7b3b5240761051b0
https://doi.org/10.1091/mbc.e19-07-0413
https://doi.org/10.1091/mbc.e19-07-0413
Autor:
Brenna Carey, Claudia Chalk, Jennifer Stock, Andrea Toth, Maria Klingler, Henry Greenberg, Kanji Uchida, Paritha Arumugam, Bruce C. Trapnell
Publikováno v:
J Immunol Methods
Granulocyte/macrophage colony-stimulating factor autoantibodies (GMAbs) mediate the pathogenesis of autoimmune pulmonary alveolar proteinosis (autoimmune PAP) and their quantification in serum by enzyme-linked immunosorbent assay (ELISA) – the seru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce21062dc2547e76fbd273fc6cdc80b1
https://pubmed.ncbi.nlm.nih.gov/36198356
https://pubmed.ncbi.nlm.nih.gov/36198356
Autor:
Marilou G. Narciso, Nasimuzzaman, Maureen A. Shaw, Sarah McGraw, Jeanne M. James, Bruce J. Aronow, Katherine VandenHeuvel, Punam Malik, Eric S. Mullins, Paritha Arumugam
Publikováno v:
Blood Advances. 3:1519-1532
Sickle cell anemia (SCA) is caused by a point mutation in the β-globin gene that leads to devastating downstream consequences including chronic hemolytic anemia, episodic vascular occlusion, and cumulative organ damage resulting in death. SCA patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95737874eca7824b51598d37fa14bee6
https://doi.org/10.1182/bloodadvances.2019032342
https://doi.org/10.1182/bloodadvances.2019032342
Autor:
Paritha Arumugam, Cormac McCarthy, Takuji Suzuki, Brenna Carey, Kenjiro Shima, Y. Ma, Y. Horio, Bruce C. Trapnell
Publikováno v:
C15. C015 BEST OF PEDIATRICS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a84591f26a2853e25f0e6e27c1b54169
https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1170
https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1170