Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Parisa Karimi, Tari"'
Autor:
Shreya H Dhume, Steven A Connor, Fergil Mills, Parisa Karimi Tari, Sarah HM Au-Yeung, Benjamin Karimi, Shinichiro Oku, Reiko T Roppongi, Hiroshi Kawabe, Shernaz X Bamji, Yu Tian Wang, Nils Brose, Michael F Jackson, Ann Marie Craig, Tabrez J Siddiqui
Publikováno v:
eLife, Vol 11 (2022)
LRRTMs are postsynaptic cell adhesion proteins that have region-restricted expression in the brain. To determine their role in the molecular organization of synapses in vivo, we studied synapse development and plasticity in hippocampal neuronal circu
Externí odkaz:
https://doaj.org/article/34f1f7432bce4e58b14dc493955892e7
Autor:
JP Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari, Celine Dube, Samuel J Goodchild, Jean-Christophe Andrez, Girish Bankar, David Bogucki, Kristen Burford, Elaine Chang, Sultan Chowdhury, Richard Dean, Gina de Boer, Shannon Decker, Christoph Dehnhardt, Mandy Feng, Wei Gong, Michael Grimwood, Abid Hasan, Angela Hussainkhel, Qi Jia, Stephanie Lee, Jenny Li, Sophia Lin, Andrea Lindgren, Verner Lofstrand, Janette Mezeyova, Rostam Namdari, Karen Nelkenbrecher, Noah Gregory Shuart, Luis Sojo, Shaoyi Sun, Matthew Taron, Matthew Waldbrook, Diana Weeratunge, Steven Wesolowski, Aaron Williams, Michael Wilson, Zhiwei Xie, Rhena Yoo, Clint Young, Alla Zenova, Wei Zhang, Alison J Cutts, Robin P Sherrington, Simon N Pimstone, Raymond Winquist, Charles J Cohen, James R Empfield
Publikováno v:
eLife, Vol 11 (2022)
NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target NaV1.6 channels. Such a molecule provides a precision-medicine approach to target SCN8A-related epilepsy syndromes (SCN8A-RES), where gain-of-function (G
Externí odkaz:
https://doaj.org/article/ff1c4ccf767e411f85c1b12a0db8fe55
Autor:
Steven A. Connor, Ina Ammendrup-Johnsen, Yasushi Kishimoto, Parisa Karimi Tari, Vedrana Cvetkovska, Takashi Harada, Daiki Ojima, Tohru Yamamoto, Yu Tian Wang, Ann Marie Craig
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3637-3645 (2017)
Synaptopathies contributing to neurodevelopmental disorders are linked to mutations in synaptic organizing molecules, including postsynaptic neuroligins, presynaptic neurexins, and MDGAs, which regulate their interaction. The role of MDGA1 in suppres
Externí odkaz:
https://doaj.org/article/9fc003b4b38d40e79f79de568050d0ed
Autor:
Shreya H Dhume, Steven A Connor, Fergil Mills, Parisa Karimi Tari, Sarah HM Au-Yeung, Benjamin Karimi, Shinichiro Oku, Reiko T Roppongi, Hiroshi Kawabe, Shernaz X Bamji, Yu Tian Wang, Nils Brose, Michael F Jackson, Ann Marie Craig, Tabrez J Siddiqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1d6ca4bdff359b135067d7dad08bcc8
https://doi.org/10.7554/elife.64742.sa2
https://doi.org/10.7554/elife.64742.sa2
Autor:
Sultan Chowdhury, David Bogucki, Rostam Namdari, Girish Bankar, Wei Zhang, James Roy Empfield, Matthew Waldbrook, Stephanie M Lee, Lofstrand Verner Alexander, Karen Nelkenbrecher, Samuel J. Goodchild, Rhena Yoo, Noah G. Shuart, Wesolowski Steven Sigmund, Elaine Chang, Mandy Feng, Clint Young, Christoph Martin Dehnhardt, Jenny Li, Zhiwei Xie, Michael Edward Grimwood, Abid Hasan, Sophia Lin, Kristen Burford, Raymond J. Winquist, Charles J. Cohen, Alla Yurevna Zenova, Simon N. Pimstone, Michael R. Wilson, Parisa Karimi Tari, Kuldip Khakh, Celine Dube, Aaron M. Williams, Robin Sherrington, Luis Sojo, Andrea Lindgren, J. P. Johnson, Thilo Focken, Qi Jia, Jean-Christophe Andrez, Shannon Decker, Matthew Taron, Diana Weeratunge, Richard T. Dean, Janette Mezeyova, Shaoyi Sun, Wei Gong, Angela Hussainkhel, Gina de Boer, Alison Jane Cutts
NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target NaV1.6 channels. Such a molecule provides a precision-medicine approach to target SCN8A-related epilepsy syndromes (SCN8A-RES), where gain-of-function (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32e2e6674136369f3abcd5070b52e762
https://doi.org/10.1101/2021.08.29.458125
https://doi.org/10.1101/2021.08.29.458125
Autor:
J P, Johnson, Thilo, Focken, Kuldip, Khakh, Parisa Karimi, Tari, Celine, Dube, Samuel J, Goodchild, Jean-Christophe, Andrez, Girish, Bankar, David, Bogucki, Kristen, Burford, Elaine, Chang, Sultan, Chowdhury, Richard, Dean, Gina, de Boer, Shannon, Decker, Christoph, Dehnhardt, Mandy, Feng, Wei, Gong, Michael, Grimwood, Abid, Hasan, Angela, Hussainkhel, Qi, Jia, Stephanie, Lee, Jenny, Li, Sophia, Lin, Andrea, Lindgren, Verner, Lofstrand, Janette, Mezeyova, Rostam, Namdari, Karen, Nelkenbrecher, Noah Gregory, Shuart, Luis, Sojo, Shaoyi, Sun, Matthew, Taron, Matthew, Waldbrook, Diana, Weeratunge, Steven, Wesolowski, Aaron, Williams, Michael, Wilson, Zhiwei, Xie, Rhena, Yoo, Clint, Young, Alla, Zenova, Wei, Zhang, Alison J, Cutts, Robin P, Sherrington, Simon N, Pimstone, Raymond, Winquist, Charles J, Cohen, James R, Empfield
Publikováno v:
eLife. 11
NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to specifically target Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3cf389ce4c308fb570995099c2f50504
https://pubmed.ncbi.nlm.nih.gov/35234610
https://pubmed.ncbi.nlm.nih.gov/35234610
Autor:
Parisa Karimi Tari, Charles J. Cohen, Matthew Waldbrook, Christoph Martin Dehnhardt, Clint Young, Maegan Soriano, Rainbow Kwan, Matt Taron, Kristen Burford, Sultan Chowdhury, Noah G. Shuart, Lofstrand Verner Alexander, Michael D. Wilson, Karen Nelkenbrecher, Jean-Christophe Andrez, Michael Edward Grimwood, Wei Gong, Robert J. DeVita, J. P. Johnson, James Roy Empfield, Alla Yurevna Zenova, Luis Sojo, Andrea Lindgren, Thilo Focken, Shannon Decker, Gina de Boer, Samuel J. Goodchild, Wesolowski Steven Sigmund, Sophia Lin, Stephanie Lee
Publikováno v:
Journal of Medicinal Chemistry. 62:9618-9641
Nonselective antagonists of voltage-gated sodium (NaV) channels have been long used for the treatment of epilepsies. The efficacy of these drugs is thought to be due to the block of sodium channels on excitatory neurons, primarily NaV1.6 and NaV1.2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25eea9fc94c4d0a50d32b1585395b3e1
https://doi.org/10.1021/acs.jmedchem.9b01032
https://doi.org/10.1021/acs.jmedchem.9b01032
Autor:
Shreya H Dhume, Steven A Connor, Fergil Mills, Parisa Karimi Tari, Sarah HM Au-Yeung, Benjamin Karimi, Shinichiro Oku, Reiko T Roppongi, Hiroshi Kawabe, Shernaz X Bamji, Yu Tian Wang, Nils Brose, Michael F Jackson, Ann Marie Craig, Tabrez J Siddiqui
Publikováno v:
eLife
LRRTMs are postsynaptic cell adhesion proteins that have region-restricted expression in the brain. To determine their role in the molecular organization of synapses in vivo, we studied synapse development and plasticity in hippocampal neuronal circu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f87bd816a59f256029ce55342c72b7b
https://pubmed.ncbi.nlm.nih.gov/35662394
https://pubmed.ncbi.nlm.nih.gov/35662394
Autor:
Girish Bankar, Charles J. Cohen, Bowen Li, Kuldip Khakh, Sultan Chowdhury, Elaine Chang, Paul Robert Bichler, Christoph Martin Dehnhardt, Daniel P. Sutherlin, Jodie Pang, Michael D. Wilson, Yi Zhang, Zhiwei Xie, Matthew Waldbrook, C. Lee Robinette, Jae H. Chang, Karen Nelkenbrecher, Ivan William Hemeon, Alla Yurevna Zenova, Tao Sheng, Samuel J. Goodchild, Clint Young, Navjot Chahal, Rainbow Kwan, Daniel F. Ortwine, Brian Safina, Sophia Lin, Andrew D. White, Parisa Karimi Tari, Qi Jia, J. P. Johnson, Thilo Focken, Chien-An Chen, David H. Hackos, Shannon Decker, Noah G. Shuart, Luis Sojo, Christine Chabot, Shaoyi Sun, Michael Edward Grimwood
Publikováno v:
Journal of Medicinal Chemistry. 61:4810-4831
The sodium channel NaV1.7 has emerged as a promising target for the treatment of pain based on strong genetic validation of its role in nociception. In recent years, a number of aryl and acyl sulfonamides have been reported as potent inhibitors of Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::301a3d7aee1781be0e40a336f69ca411
https://doi.org/10.1021/acs.jmedchem.7b01826
https://doi.org/10.1021/acs.jmedchem.7b01826
Autor:
Parisa Karimi Tari, Yu Tian Wang, Ann Marie Craig, Vedrana Cvetkovska, Tohru Yamamoto, Ina Ammendrup-Johnsen, Yasushi Kishimoto, Daiki Ojima, Takashi Harada, Steven A. Connor
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3637-3645 (2017)
Summary Synaptopathies contributing to neurodevelopmental disorders are linked to mutations in synaptic organizing molecules, including postsynaptic neuroligins, presynaptic neurexins, and MDGAs, which regulate their interaction. The role of MDGA1 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad1d4ef3758a600a1f96b7bbd981ad9
http://www.sciencedirect.com/science/article/pii/S221112471731793X
http://www.sciencedirect.com/science/article/pii/S221112471731793X