Výsledky vyhledávání - "Parisa Amjadi"

Methotrexate Restores Regulatory T Cell Function Through Demethylation of the FoxP3 Upstream Enhancer in Patients With Rheumatoid Arthritis

Autor: Bernard Gregory, Alan Kennedy, Jordan E. Read, Richard O. Williams, Adam P. Cribbs, Patricia Green, Fionula M. Brennan, Parisa Amjadi, Henry Penn

Publikováno v: Arthritis & Rheumatology. 67:1182-1192

Objective We have previously shown, in a cohort of untreated rheumatoid arthritis (RA) patients, that the suppressive function of Treg cells is defective. However, other studies in cohorts of patients with established RA have shown that Treg cell fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f28fb792c7db5bfab8e5c785ce928a0
https://doi.org/10.1002/art.39031

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Human blood CD1c dendritic cells stimulate IL-12-independent IFN-γ responses and have a strikingly low inflammatory profile

Autor: Tom Ford, Peter Kelleher, Steven Patterson, Sai Duraisingham, Adel Benlahrech, Lisa Verhagen, Douglas King, George Rozis, Parisa Amjadi

Publikováno v: Journal of Leukocyte Biology. 97:873-885

Adaptive immune responses are initiated by resident myeloid tissue DC. A major fraction of tissue DC express CD1c+ and is thought to be derived from blood CD1c DC, an idea supported here by the observation that they express tissue-homing molecules an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfe2874d615d2945ed4cf991bfe62df1
https://doi.org/10.1189/jlb.1a0114-058rr

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Treg Cell Function in Rheumatoid Arthritis Is Compromised by CTLA-4 Promoter Methylation Resulting in a Failure to Activate the Indoleamine 2,3-Dioxygenase Pathway

Autor: Alan Kennedy, Richard O. Williams, Fionula M. Brennan, Szymon W. Manka, Bernard Gregory, Khaja Syed, Adam P. Cribbs, Henry Penn, Parisa Amjadi, Patricia Green, Jordan E. Read

Publikováno v: Arthritis & Rheumatology. 66:2344-2354

Objective. Functionally impaired Treg cells expressing abnormally low levels of CTLA-4 have been well documented in rheumatoid arthritis (RA). However, the molecular defect underlying this reduced expression is unknown. The aims of this study were to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9ebef1539346f10fc871dfae1a8616d
https://doi.org/10.1002/art.38715

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A novel upstream enhancer ofFOXP3, sensitive to methylation-induced silencing, exhibits dysregulated methylation in rheumatoid arthritis Treg cells

Autor: Parisa Amjadi, Henry Penn, Adam P. Cribbs, Bernard Gregory, Khaja Syed, Fionula M. Brennan, Alan Kennedy, Emily M. Schmidt, Patricia Green, Jordan E. Read

Publikováno v: European Journal of Immunology. 44:2968-2978

Treg-cell function is compromised in rheumatoid arthritis (RA). As the master regulator of Treg cells, FOXP3 controls development and suppressive function. Stable Treg-cell FOXP3 expression is epigenetically regulated; constitutive expression require

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac8d6f5f3100784ff96bb56f67ef5a70
https://doi.org/10.1002/eji.201444453

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Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism

Autor: Patricia Green, Parisa Amjadi, Masao Takata, Montserrat Alvarez-Iglesias, Heidi J. Robertshaw, Fionula M. Brennan

IL-10 is a potent anti-inflammatory molecule, which regulates TNF-alpha at multiple levels. We investigated whether IL-10 also modulated the activity of the TNF-alpha-converting enzyme (TACE). Using an ex vivo fluorogenic assay we observed that LPS r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c528f22dee76897cb63b004d496eb5a
https://ora.ox.ac.uk/objects/uuid:5d0b4101-c0c0-497f-956a-6668df09603e

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Activation of p38 mitogen-activated protein kinase is critical step for acquisition of effector function in cytokine-activated T cells, but acts as a negative regulator in T cells activated through the T-cell receptor

Autor: Andrew C. Palfreeman, Parisa Amjadi, Ching Li, Alan Kennedy, Fionula M. Brennan, Paul A. Beavis

Publikováno v: Immunology. 132:104-110

Peripheral blood CD4(+) CD45RO(+) T cells activated in vitro are able to induce expression of tumour necrosis factor-α (TNF-α) in monocytes via a contact-dependent mechanism. Activation is achieved either with interleukin-2 (IL-2)/IL-6/TNF-α over

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cf65815df0cc3bc66d2c5e5331a8f6b
https://doi.org/10.1111/j.1365-2567.2010.03345.x

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The Toll-Like Receptor Adaptor Proteins MyD88 and Mal/TIRAP Contribute to the Inflammatory and Destructive Processes in a Human Model of Rheumatoid Arthritis

Autor: Anna M. Lundberg, Brian M. J. Foxwell, Marc Feldmann, Evangelos Andreakos, Serafim Kiriakidis, Parisa Amjadi, Fionula M. Brennan, Grey Giddins, Sandra Sacre

Publikováno v: The American Journal of Pathology. 170:518-525

The widespread distribution of Toll-like receptors (TLRs) and their ligands raises the question whether they contribute to the production of inflammatory and tissue destructive molecules in rheumatoid arthritis (RA). We examined the expression and fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef24a5af1fd1d6b488d0f1fec222f8c
https://doi.org/10.2353/ajpath.2007.060657

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Human BDCA-1-Positive Blood Dendritic Cells Differentiate into Phenotypically Distinct Immature and Mature Populations in the Absence of Exogenous Maturational Stimuli: Differentiation Failure in HIV Infection

Autor: Heather Donaghy, Frances Gotch, Peter Kelleher, Brian Gazzard, Parisa Amjadi, Steven Patterson

Publikováno v: The Journal of Immunology. 174:8200-8209

Current immunological opinion holds that myeloid dendritic cell (mDC) precursors migrate from the blood to the tissues, where they differentiate into immature dermal- and Langerhans-type dendritic cells (DC). Tissue DC require appropriate signals fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6016c0bf5f63612dd43887acb909428
https://doi.org/10.4049/jimmunol.174.12.8200

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Methotrexate Restores Regulatory T Cell Function Through Demethylation of the FoxP3 Upstream Enhancer in Patients With Rheumatoid Arthritis

Autor: Adam P, Cribbs, Alan, Kennedy, Henry, Penn, Parisa, Amjadi, Patricia, Green, Jordan E, Read, Fionula, Brennan, Bernard, Gregory, Richard O, Williams

Publikováno v: Arthritisrheumatology (Hoboken, N.J.). 67(5)

We have previously shown, in a cohort of untreated rheumatoid arthritis (RA) patients, that the suppressive function of Treg cells is defective. However, other studies in cohorts of patients with established RA have shown that Treg cell function is n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0909da4df9e6b239fd7224e54368eecc
https://pubmed.ncbi.nlm.nih.gov/25604080

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