Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Paris Margaritis"'
Autor:
Charles E Hay, Guillermo A Gonzalez, Laura E Ewing, E Elizabeth Reichard, Michael D Hambuchen, Nisha Nanaware-Kharade, Sinthia Alam, Chris T Bolden, S Michael Owens, Paris Margaritis, Eric C Peterson
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0200060 (2018)
Methamphetamine (METH) substance abuse disorders have major impact on society, yet no medications have proven successful at preventing METH relapse or cravings. Anti-METH monoclonal antibodies can reduce METH brain concentrations; however, this thera
Externí odkaz:
https://doaj.org/article/a3b7cda581564b6da93d3379f3633e3c
Autor:
Juliana C. Small, Shannon M. Zintner, Malte Selch Larsen, Bo Wiinberg, Mattias Häger, Paris Margaritis, K. M. Lövgren, Maj Petersen, Mads Kjelgaard-Hansen
Publikováno v:
J Thromb Haemost
Background Prophylactic replacement therapy in hemophilia A (HA) patients does not adequately prevent bleeds and arthropathic complications. A more refined understanding of the relationship between coagulation factor VIII (FVIII) levels and bleeding
Autor:
Mads Kreilgaard, Bo Wiinberg, Annemarie T. Kristensen, Ulrika S. H. Simonsson, Mads Kjelgaard-Hansen, Shannon M. Zintner, Malte Selch Larsen, Paris Margaritis, Rasmus Vestergaard Juul
Publikováno v:
Haemophilia. 26:164-172
Introduction Monitoring of clinical effectiveness of bypassing agents in haemophilia patients is hampered by the lack of validated laboratory assays. Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) have been evaluated for predicti
Autor:
Eric C. Peterson, Michael D. Hambuchen, William E. Fantegrossi, Laura E. Ewing, Chris Bolden, Juliana C. Small, S. Michael Owens, Shannon M. Zintner, Charles E. Hay, Paris Margaritis
Publikováno v:
J Pharmacol Exp Ther
Methamphetamine (METH) continues to be among the most addictive and abused drugs in the United States. Unfortunately, there are currently no Food and Drug Administration–approved pharmacological treatments for METH-use disorder. We have previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9ec0f295f976f25a681a4752579cf3
https://europepmc.org/articles/PMC7289050/
https://europepmc.org/articles/PMC7289050/
Publikováno v:
Blood. 138:1025-1025
The development of neutralizing antibodies (inhibitors) to factor VIII (FVIII) remains the most challenging complication of protein-based replacement therapy in hemophilia A (HA). Elevated levels of the B cell survival cytokine B cell activating fact
Autor:
Chris Bolden, S. Michael Owens, Michael D. Hambuchen, Paris Margaritis, Laura E. Ewing, William E. Fantegrossi, Shannon M. Zintner, Eric C. Peterson, Charles E. Hay, Juliana C. Small
Methamphetamine (METH) continues to be amongst the most addictive and abused drugs in the US. Unfortunately, there are currently no FDA approved pharmacological treatments for METH substance abuse disorder. As an alternative approach, we have previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ccbb65f823838cd30a8342555b0ba2b
https://doi.org/10.1101/687129
https://doi.org/10.1101/687129
Autor:
Rebecca N Jerome, Andrew J. Monteith, Jill M. Pulley, Lauren E. Himmel, Jacob E. Choby, Jana K. Shirey-Rice, Eric P. Skaar, Andrea J. Pruijssers, Paris Margaritis
Coagulation and inflammation are interconnected, suggesting that coagulation plays a key role in the inflammatory response to pathogens. A phenome-wide association study (PheWAS) was used to identify clinical phenotypes of patients with a polymorphis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13233fd508b5355f51b8a46bf31be17
https://europepmc.org/articles/PMC6479028/
https://europepmc.org/articles/PMC6479028/
Autor:
Katherine A. High, Paris Margaritis, Timothy C. Nichols, Robin A. Raymer, Shannon M. Smith, Giulia Pavani, Shangzhen Zhou, Dwight A. Bellinger, Oscar A. Marcos-Contreras, Armida Faella, Elizabeth P. Merricks
Publikováno v:
Blood. 127:565-571
Factor VII (FVII) deficiency is a rare autosomal recessive bleeding disorder treated by infusion of fresh-frozen plasma, plasma-derived FVII concentrates and low-dose recombinant activated FVII. Clinical data suggest that a mild elevation of plasma F
Autor:
Bo Wiinberg, Shannon M. Zintner, Lynn E Dankner, Phyllis A. Gimotty, Juliana C. Small, Paris Margaritis, Mads Kjelgaard-Hansen, Oscar A. Marcos-Contreras, Giulia Pavani
Publikováno v:
Blood advances. 3(3)
A sizable proportion of hemophilia inhibitor patients fails immune tolerance induction and requires bypass agents for long-term bleed management. Recombinant human-activated coagulation Factor VII (rhFVIIa) is an on-demand bypass hemostatic agent for
Publikováno v:
Blood. 134:3629-3629
The endothelial protein C receptor (EPCR) has been demonstrated to bind activated FVII (FVIIa) through the Gla domain with equal affinity to Protein C (PC). Mouse studies suggest that EPCR is involved in the extravasation of infused human FVIIa, lead