Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Parinaz C. Pircher"'
Autor:
Mary Petrowski, Tie-Lin Wang, Paige Mahaney, Chris L. Daige, Richard Martin, Grace Yan, Jay Wrobel, Jiali Li, Parinaz C. Pircher, Xiao-Hui Gu, Eric D. Bischoff, Raju Mohan, Stefan Westin, Brenton T. Flatt, Paul Foster, Brett Murphy, Ira G. Schulman
Publikováno v:
Journal of Medicinal Chemistry. 52:904-907
Azepino[4,5-b]indoles have been identified as potent agonists of the farnesoid X receptor (FXR). In vitro and in vivo optimization has led to the discovery of 6m (XL335, WAY-362450) as a potent, selective, and orally bioavailable FXR agonist (EC(50)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22bdda82f6d2ea078670fd48d355abad
https://doi.org/10.1021/jm8014124
https://doi.org/10.1021/jm8014124
Autor:
Jennifer L. Kitto, Eric D. Bischoff, Mary Petrowski, Rajendra K. Tangirala, Parinaz C. Pircher, Stefan Westin, Ira G. Schulman
Publikováno v:
The Journal of biological chemistry. 278(30)
The farnesoid X receptor (FXR; NR1H4) regulates bile acid and lipid homeostasis by acting as an intracellular bile acid-sensing transcription factor. Several identified FXR target genes serve critical roles in the synthesis and transport of bile acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703897014f0964613149eafe9a66ab6d
https://pubmed.ncbi.nlm.nih.gov/12754200
https://pubmed.ncbi.nlm.nih.gov/12754200