An aberrant immune-epithelial progenitor niche drives viral lung sequelae.

Autor: Narasimhan H; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA.; Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA, USA., Cheon IS; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA.; Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA., Qian W; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA.; Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA., Hu SS; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Parimon T; Women's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Li C; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA.; Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA., Goplen N; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Wu Y; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA.; Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA., Wei X; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA.; Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA., Son YM; Department of Systems Biotechnology, Chung-Ang University, Anseong, Korea., Fink E; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA.; Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA., de Almeida Santos G; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA.; Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA., Tang J; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA.; Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA., Yao C; Women's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Muehling L; Division of Asthma, Allergy and Immunology, Department of Medicine, University of Virginia, Charlottesville, VA, USA., Canderan G; Division of Asthma, Allergy and Immunology, Department of Medicine, University of Virginia, Charlottesville, VA, USA., Kadl A; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, VA, USA., Cannon A; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA.; Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA., Young S; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA.; Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA, USA., Hannan R; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, VA, USA., Bingham G; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA., Arish M; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA.; Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA., Sen Chaudhari A; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA.; Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA., Im JS; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA.; Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA., Mattingly CLR; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.; Emory Center of Excellence for Influenza Research and Response, Atlanta, GA, USA., Pramoonjago P; School of Medicine, University of Virginia, Charlottesville, VA, USA., Marchesvsky A; Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Sturek J; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, VA, USA., Kohlmeier JE; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.; Emory Center of Excellence for Influenza Research and Response, Atlanta, GA, USA., Shim YM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, VA, USA., Woodfolk J; Division of Asthma, Allergy and Immunology, Department of Medicine, University of Virginia, Charlottesville, VA, USA., Zang C; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA. zang@virginia.edu., Chen P; Women's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Peter.Chen@cshs.org.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Peter.Chen@cshs.org., Sun J; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA. js6re@virginia.edu.; Division of Infectious Disease and International Health, Department of Medicine, University of Virginia, Charlottesville, VA, USA. js6re@virginia.edu.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA, USA. js6re@virginia.edu.

Publikováno v: Nature [Nature] 2024 Oct; Vol. 634 (8035), pp. 961-969. Date of Electronic Publication: 2024 Sep 04.

Fibroblast-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosis.

Autor: Burgy O; INSERM U1231 Center for Translational and Molecular Medicine (CTM), Faculty of Health Sciences, Université de Bourgogne, Dijon, France.; Reference Center for Rare Pulmonary Diseases, University Hospital Dijon-Bourgogne, Dijon, France., Mayr CH; Institute of Experimental Pneumology, LMU University Hospital, Ludwig-Maximilians University, Munich, Germany., Schenesse D; INSERM U1231 Center for Translational and Molecular Medicine (CTM), Faculty of Health Sciences, Université de Bourgogne, Dijon, France.; Reference Center for Rare Pulmonary Diseases, University Hospital Dijon-Bourgogne, Dijon, France.; Department of Pulmonary Medicine and Intensive Care Unit, University Hospital Dijon-Bourgogne, Dijon, France., Fousekis Papakonstantinou E; Institute for Lung Research, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany., Ballester B; Comprehensive Pneumology Center (CPC) with the CPC-M BioArchive and Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Member of the DZL, Munich, Germany.; Faculty of Health Sciences, Universidad CEU Cardenal Herrera, CEU Universities, Valencia, Spain., Sengupta A; Comprehensive Pneumology Center (CPC) with the CPC-M BioArchive and Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Member of the DZL, Munich, Germany., She Y; Center for Lung Aging and Regeneration (CLAR), Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Hu Q; Center for Lung Aging and Regeneration (CLAR), Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Melo-Narvaéz MC; Institute for Lung Research, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.; Comprehensive Pneumology Center (CPC) with the CPC-M BioArchive and Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Member of the DZL, Munich, Germany., Jain E; Comprehensive Pneumology Center (CPC) with the CPC-M BioArchive and Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Member of the DZL, Munich, Germany., Pestoni JC; Comprehensive Pneumology Center (CPC) with the CPC-M BioArchive and Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Member of the DZL, Munich, Germany., Mozurak M; Center for Lung Aging and Regeneration (CLAR), Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Estrada-Bernal A; Center for Lung Aging and Regeneration (CLAR), Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Onwuka U; Center for Lung Aging and Regeneration (CLAR), Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Coughlan C; Division of Neurology, Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA., Parimon T; Women's Guild Lung Institute, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Chen P; Women's Guild Lung Institute, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Heimerl T; Center for Synthetic Microbiology (SYNMIKRO) and., Bange G; Center for Synthetic Microbiology (SYNMIKRO) and., Schmeck BT; Department of Pulmonary Medicine and Intensive Care Unit, University Hospital Dijon-Bourgogne, Dijon, France.; Center for Synthetic Microbiology (SYNMIKRO) and.; Core Facility Flow Cytometry - Bacterial Vesicles, Philipps-University Marburg, Marburg, Germany.; Universities of Giessen and Marburg Lung Center (UGMLC) Giessen Biobank, Justus-Liebig-University Giessen, DZL, Giessen, Germany., Lindner M; Comprehensive Pneumology Center (CPC) with the CPC-M BioArchive and Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Member of the DZL, Munich, Germany.; Paracelsus Medical Private University, Salzburg, Austria., Hilgendorff A; Comprehensive Pneumology Center (CPC) with the CPC-M BioArchive and Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Member of the DZL, Munich, Germany., Ruppert C; Universities of Giessen and Marburg Lung Center (UGMLC) Giessen Biobank, Justus-Liebig-University Giessen, DZL, Giessen, Germany., Güenther A; Universities of Giessen and Marburg Lung Center (UGMLC) Giessen Biobank, Justus-Liebig-University Giessen, DZL, Giessen, Germany.; European IPF Registry (eurIPFreg), Center for Interstitial and Rare Lung Diseases, UGMLC, Justus-Liebig University Giessen, DZL, Giessen, Germany., Mann M; Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany., Yildirim AÖ; Comprehensive Pneumology Center (CPC) with the CPC-M BioArchive and Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Member of the DZL, Munich, Germany., Eickelberg O; Center for Lung Aging and Regeneration (CLAR), Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Jung AL; Institute for Lung Research, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.; Core Facility Flow Cytometry - Bacterial Vesicles, Philipps-University Marburg, Marburg, Germany., Schiller HB; Institute of Experimental Pneumology, LMU University Hospital, Ludwig-Maximilians University, Munich, Germany.; Research Unit for Precision Regenerative Medicine, Helmholtz Munich, Munich, Germany., Lehmann M; Institute for Lung Research, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.; Comprehensive Pneumology Center (CPC) with the CPC-M BioArchive and Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Member of the DZL, Munich, Germany., Burgstaller G; Comprehensive Pneumology Center (CPC) with the CPC-M BioArchive and Institute of Lung Health and Immunity (LHI), Helmholtz Munich, Member of the DZL, Munich, Germany., Königshoff M; Center for Lung Aging and Regeneration (CLAR), Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Geriatric Research Education and Clinical Center (GRECC) at the VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.

Publikováno v: JCI insight [JCI Insight] 2024 Aug 15; Vol. 9 (18). Date of Electronic Publication: 2024 Aug 15.

Interstitial Macrophages Mediate Efferocytosis of Alveolar Epithelium during Influenza Infection.

Autor: Zuttion MSSR; Women's Guild Lung Institute, Department of Medicine, and., Parimon T; Women's Guild Lung Institute, Department of Medicine, and., Yao C; Women's Guild Lung Institute, Department of Medicine, and., Stripp BR; Women's Guild Lung Institute, Department of Medicine, and.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California; and., Wang Y; Women's Guild Lung Institute, Department of Medicine, and., Soto CM; Women's Guild Lung Institute, Department of Medicine, and., Ortega Z; Women's Guild Lung Institute, Department of Medicine, and., Li X; Women's Guild Lung Institute, Department of Medicine, and., Janssen WJ; Division of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, Colorado., Chen P; Women's Guild Lung Institute, Department of Medicine, and.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California; and.

Publikováno v: American journal of respiratory cell and molecular biology [Am J Respir Cell Mol Biol] 2024 Mar; Vol. 70 (3), pp. 159-164.

Translational Studies Reveal the Divergent Effects of Simtuzumab Targeting LOXL2 in Idiopathic Pulmonary Fibrosis.

Autor: Espindola MS; Women's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Habiel DM; Women's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Coelho AL; Women's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Parimon T; Women's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Chen P; Women's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Mikels-Vigdal A; Department of Biology, Gilead Sciences, Inc., Foster City, CA 94404, USA., Hogaboam CM; Women's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Publikováno v: Fibrosis (Hong Kong, China) [Fibrosis (Hong Kong)] 2023 Dec; Vol. 1 (2). Date of Electronic Publication: 2023 Nov 28.

Physical activity and cognitive function in individuals over 60 years of age: a systematic review

Autor: Carvalho A, Rea IM, Parimon T, Cusack BJ

Publikováno v: Clinical Interventions in Aging, Vol Volume 9, Pp 661-682 (2014)

Ashley Carvalho,1,2 Irene Maeve Rea,2 Tanyalak Parimon,3,4 Barry J Cusack3,51Department of Public Health, 2School of Medicine, Dentistry and Biomedical Science, Queen’s University Belfast, Northern Ireland, UK; 3Research and Development Service, Ve

Externí odkaz: https://doaj.org/article/1c752b5ee7744c73baf2efd5cb6ff885