Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Parimala Sonika Godavarthy"'
Autor:
Raquel S. Pereira, Rahul Kumar, Alessia Cais, Lara Paulini, Alisa Kahler, Jimena Bravo, Valentina R. Minciacchi, Theresa Krack, Eric Kowarz, Costanza Zanetti, Parimala Sonika Godavarthy, Fabian Hoeller, Pablo Llavona, Tabea Stark, Georg Tascher, Daniel Nowak, Eshwar Meduri, Brian J. P. Huntly, Christian Münch, Francesco Pampaloni, Rolf Marschalek, Daniela S. Krause
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Haematopoietic stem cells (HSC) reside in the bone marrow microenvironment (BMM), where they respond to extracellular calcium [eCa2+] via the G-protein coupled calcium-sensing receptor (CaSR). Here we show that a calcium gradient exists in t
Externí odkaz:
https://doaj.org/article/00699074cde14bba837f1807407edcf5
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
In the adult organism, hematopoietic stem and progenitor cells (HSPC) reside in the bone marrow (BM) in specialized hematopoietic stem cell niches of which the extracellular matrix (ECM) is an integral component. Laminins (LM) are a family of heterot
Externí odkaz:
https://doaj.org/article/08686a8e9a4d4ef89dda48c31dd61372
Autor:
Parimala Sonika Godavarthy, Rahul Kumar, Stefanie C. Herkt, Raquel S. Pereira, Nina Hayduk, Eva S. Weissenberger, Djamel Aggoune, Yosif Manavski, Tina Lucas, Kuan-Ting Pan, Jenna M. Voutsinas, Qian Wu, Martin C. Müller, Susanne Saussele, Thomas Oellerich, Vivian G. Oehler, Joern Lausen, Daniela S. Krause
Publikováno v:
Haematologica, Vol 105, Iss 1 (2020)
The endosteal bone marrow niche and vascular endothelial cells provide sanctuaries for leukemic cells. In murine chronic myeloid leukemia (CML) CD44 on leukemia cells and E-selectin on bone marrow endothelium are essential mediators for the engraftme
Externí odkaz:
https://doaj.org/article/222bdee963a84eddb009ae8905b3bf47
Autor:
Marlon Arnone, Martina Konantz, Pauline Hanns, Anna M. Paczulla Stanger, Sarah Bertels, Parimala Sonika Godavarthy, Maximilian Christopeit, Claudia Lengerke
Publikováno v:
Cancers, Vol 12, Iss 12, p 3742 (2020)
Patients suffering from acute myeloid leukemia (AML) show highly heterogeneous clinical outcomes. Next to variabilities in patient-specific parameters influencing treatment decisions and outcome, this is due to differences in AML biology. In fact, di
Externí odkaz:
https://doaj.org/article/557c465e584449f395b08acc4edbe3b7
Autor:
Markus Metzler, Barbara Burroni, Costanza Zanetti, Parimala Sonika Godavarthy, Véronique Maguer-Satta, Michaela Fontenay, Franck E. Nicolini, Jakob Pfeiffer, Daniela S. Krause, Rahul Kumar, Valentina R. Minciacchi, Sylvain Lefort, Divij Verma
Publikováno v:
Leukemia
Leukemia, Nature Publishing Group: Open Access Hybrid Model Option B, 2020, 34 (6), pp.1540-1552. ⟨10.1038/s41375-019-0674-7⟩
Leukemia, Nature Publishing Group: Open Access Hybrid Model Option B, 2020, 34 (6), pp.1540-1552. ⟨10.1038/s41375-019-0674-7⟩
Specific and reciprocal interactions with the bone marrow microenvironment (BMM) govern the course of hematological malignancies. Matrix metalloproteinase-9 (MMP-9), secreted by leukemia cells, facilitates tumor progression via remodeling of the extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e38c8cc7b16f8a2aa0a6ce2b018d511
https://hal.archives-ouvertes.fr/hal-03426118/document
https://hal.archives-ouvertes.fr/hal-03426118/document
Autor:
Martina Konantz, Sarah Bertels, Pauline Hanns, Anna M. Paczulla Stanger, Marlon Arnone, Claudia Lengerke, Parimala Sonika Godavarthy, Maximilian Christopeit
Publikováno v:
Cancers
Cancers, Vol 12, Iss 3742, p 3742 (2020)
Cancers, Vol 12, Iss 3742, p 3742 (2020)
Simple Summary Relapse after apparent remission remains a major cause of death in patients with acute myeloid leukemia (AML). On the cellular level, leukemia relapse is considered to emerge from subpopulations of therapy-resistant leukemic stem cells
Autor:
Thomas Oellerich, Birgitta E. Michels, Katharina Gerlach, Parimala Sonika Godavarthy, Vivian G. Oehler, Astrid Wachter, Pablo Llavona, Daniela S. Krause, Uta Müller-Kuller, Hanibal Bohnenberger, Jenna M. Voutsinas, Martin Zörnig, Divij Verma, Henner F. Farin, Marlene Steiner, Van T. Hoang, Eva Weissenberger
Publikováno v:
Leukemia. 33(7)
The transcriptional regulator far upstream element binding protein 1 (FUBP1) acts as an oncoprotein in solid tumor entities and plays a role in the maintenance of hematopoietic stem cells. However, its potential function in leukemia is unknown. In mu
Autor:
Parimala Sonika Godavarthy, Costanza Zanetti, Melanie Meister, Daniela S. Krause, Rahul Kumar, Alex Azimpour, Raquel S. Pereira, Julian Niemann
Publikováno v:
Blood. 134:2921-2921
Introduction The role of the bone marrow (BM) microenvironment (BMM) for the regulation of leukaemic stem cells (LSC) and their respective interplay is slowly being elucidated, but knowledge about how membrane structures or adhesion molecules on leuk
Autor:
Costanza Zanetti, Wendy Stock, Kathryn G. Roberts, Joscha Ender, Eva Weissenberger, Markus Metzler, Daniel B. Lipka, Joschka Hey, Zhaohui Gu, Natalie Filmann, Parimala Sonika Godavarthy, Clara D. Bloomfield, Charles G. Mullighan, Daniela S. Krause, Rahul Kumar, Mark Hartmann
Publikováno v:
Blood. 134:2748-2748
B-cell acute lymphoblastic leukaemia (B-ALL) occurs most commonly in children, while chronic myeloid leukaemia (CML) is more frequent in adults. So far, the myeloid bias of haematopoiesis in elderly people has been considered the main reason for thes
Autor:
Juliane Mohr, Tina M. Schnöder, Florian Perner, Parimala Sonika Godavarthy, Rüdiger C. Braun-Dullaeus, Sönke Weinert, Costanza Zanetti, Florian H. Heidel, Banaja P. Dash, Carolin Herzog, Carolin Kathner, Björn Hartleben, Daniela S. Krause, Michael Naumann, Thilo Kähne, Tobias B. Huber, Gerd Walz, Sarah Ellis, Valera Vasioukhin
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Cell fate determinants Scrib and Llgl1 influence self-renewal capacity of hematopoietic stem cells (HSCs). Scrib-deficient HSCs are functionally impaired and lack sufficient repopulation capacity during serial transplantation and stress. In contrast,