Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Parimal Sheth"'
Publikováno v:
The Journal of Nutritional Biochemistry. 64:128-143
Recent study indicated that glutamine prevents alcoholic tissue injury in mouse gut and liver. Here we investigated the potential role of Epidermal Growth Factor Receptor (EGFR) in glutamine-mediated prevention of ethanol-induced colonic barrier dysf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c46076618d9478a20db585fda76e736
https://doi.org/10.1016/j.jnutbio.2018.10.016
https://doi.org/10.1016/j.jnutbio.2018.10.016
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 299:G186-G195
Recent studies showed that c-Src and phosphatidylinositol 3 (PI3) kinase mediate the oxidative stress-induced disruption of tight junctions in Caco-2 cell monolayers. The present study evaluated the roles of PI3 kinase and Src kinase in the oxidative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24afe52996c97c7a6985c321bd34a4f
https://doi.org/10.1152/ajpgi.00368.2009
https://doi.org/10.1152/ajpgi.00368.2009
Publikováno v:
Journal of Biological Chemistry. 282:11487-11498
Occludin is hyperphosphorylated on Ser and Thr residues in intact epithelial tight junction (TJ); however, the role of this phosphorylation in the assembly of TJ is unclear. The influence of protein phosphatases PP2A and PP1 on the assembly of TJ and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec429281a0737fa0717751c306d26b6
https://doi.org/10.1074/jbc.m610597200
https://doi.org/10.1074/jbc.m610597200
Autor:
Parimal Sheth, Francesco Giorgianni, Dominic M. Desiderio, Radhakrishna Rao, Chunying Li, Gautam Kale, Katherine J. Atkinson, Ankur Seth, Anjaparavanda P. Naren, Tarun Gheyi
Publikováno v:
Biochemical Journal. 402:291-300
Interactions between E-cadherin, beta-catenin and PTP1B (protein tyrosine phosphatase 1B) are crucial for the organization of AJs (adherens junctions) and epithelial cell-cell adhesion. In the present study, the effect of acetaldehyde on the AJs and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d259d6dcdb289eb9170fd4032127fe78
https://doi.org/10.1042/bj20060665
https://doi.org/10.1042/bj20060665
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 289:G367-G375
Acetaldehyde, a toxic metabolite of ethanol oxidation, is suggested to play a role in the increased risk for gastrointestinal cancers in alcoholics. In the present study, the effect of acetaldehyde on tyrosine phosphorylation, immmunofluorescence loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5d80fdeb0afc6750a8f308efef69e6
https://doi.org/10.1152/ajpgi.00464.2004
https://doi.org/10.1152/ajpgi.00464.2004
Publikováno v:
Alcoholism: Clinical and Experimental Research. 28:797-804
Background: Intestinal permeability and endotoxemia play a crucial role in the pathogenesis of alcoholic liver disease. Previous studies showed that acetaldehyde disrupts intestinal epithelial barrier function and increases paracellular permeability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdf8a1acf226749d878a2fc0d767a7a
https://doi.org/10.1097/01.alc.0000125358.92335.90
https://doi.org/10.1097/01.alc.0000125358.92335.90
Publikováno v:
Journal of Biological Chemistry. 278:49239-49245
A recent study (Nusrat, A., Chen, J. A., Foley, C. S., Liang, T. W., Tom, J., Cromwell, M., Quan, C., and Mrsny, R. J. (2000) J. Biol. Chem. 275, 29816-29822) suggested that phosphatidylinositol 3-kinase (PI 3-kinase) may interact with occludin; howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b3116b0f682e62c947c65fe0dc52b8
https://doi.org/10.1074/jbc.m305654200
https://doi.org/10.1074/jbc.m305654200
Evidence indicates that PP2A (protein phosphatase 2A) interacts with epithelial tight junctions and negatively regulates the integrity of the tight junction. In the present study, the role of PP2A in the hydrogen peroxide-induced disruption of the ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d12d281c1324c352031315093f8e38
https://europepmc.org/articles/PMC6202034/
https://europepmc.org/articles/PMC6202034/
Publikováno v:
The FASEB Journal. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60e3bb01a2b0610cdc837da728c5784d
https://doi.org/10.1096/fasebj.23.1_supplement.979.4
https://doi.org/10.1096/fasebj.23.1_supplement.979.4
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 293(1)
Bile duct epithelium forms a barrier to the backflow of bile into the liver parenchyma. However, the structure and regulation of the tight junctions in bile duct epithelium is not well understood. In the present study, we evaluated the effect of lipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e698bf01a3a43fc72ee37f8739de27db
https://pubmed.ncbi.nlm.nih.gov/17446308
https://pubmed.ncbi.nlm.nih.gov/17446308