Clinical Outcomes of Immune Checkpoint Inhibitors in Unique Cohorts Underrepresented in Clinical Trials.

Autor: Shah NJ; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Department of Medicine, Weill Cornell Medical Center, New York, NY 10065, USA., Della Pia A; John Theurer Cancer Center at Hackensack Meridian Health, Hackensack, NJ 07601, USA., Wu T; Department of Biostatistics, Georgetown University Medical Center, Washington, DC 20007, USA., Williams A; Hackensack Meridian Health Mountainside Medical Center, Montclair, NJ 07042, USA., Weber M; John Theurer Cancer Center at Hackensack Meridian Health, Hackensack, NJ 07601, USA., Sinclaire B; John Theurer Cancer Center at Hackensack Meridian Health, Hackensack, NJ 07601, USA., Gourna Paleoudis E; John Theurer Cancer Center at Hackensack Meridian Health, Hackensack, NJ 07601, USA., Alaoui A; Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC 20007, USA., Lev-Ari S; Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC 20007, USA., Adams S; John Theurer Cancer Center at Hackensack Meridian Health, Hackensack, NJ 07601, USA., Kaufman J; John Theurer Cancer Center at Hackensack Meridian Health, Hackensack, NJ 07601, USA., Parikh SB; John Theurer Cancer Center at Hackensack Meridian Health, Hackensack, NJ 07601, USA., Tonti E; John Theurer Cancer Center at Hackensack Meridian Health, Hackensack, NJ 07601, USA., Muller E; John Theurer Cancer Center at Hackensack Meridian Health, Hackensack, NJ 07601, USA., Serzan M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Cheruku D; Hackensack Meridian Health Mountainside Medical Center, Montclair, NJ 07042, USA., Lee A; Hackensack Meridian School of Medicine, Nutley, NJ 07110, USA., Sridhar A; Hackensack Meridian School of Medicine, Nutley, NJ 07110, USA., Hee BTP; Hackensack Meridian School of Medicine, Nutley, NJ 07110, USA., Ahn J; Department of Biostatistics, Georgetown University Medical Center, Washington, DC 20007, USA., Pecora A; John Theurer Cancer Center at Hackensack Meridian Health, Hackensack, NJ 07601, USA.; Hackensack Meridian School of Medicine, Nutley, NJ 07110, USA., Ip A; John Theurer Cancer Center at Hackensack Meridian Health, Hackensack, NJ 07601, USA.; Hackensack Meridian School of Medicine, Nutley, NJ 07110, USA., Atkins MB; Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC 20007, USA.

Publikováno v: Cancers [Cancers (Basel)] 2024 Jun 14; Vol. 16 (12). Date of Electronic Publication: 2024 Jun 14.

Successful cord blood transplantation for del7q myelodysplastic syndrome in Pearson marrow pancreas syndrome.

Autor: Belgacem ZH; Division of Hematology/Oncology and Stem Cell Program, Boston Children's Hospital, Boston, Massachusetts, USA.; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Harvard Stem Cell Institute, Harvard Initiative in RNA Medicine, Boston, Massachusetts, USA.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA., Dubois SM; Division of Hematology/Oncology and Stem Cell Program, Boston Children's Hospital, Boston, Massachusetts, USA.; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Harvard Stem Cell Institute, Harvard Initiative in RNA Medicine, Boston, Massachusetts, USA.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA., Jacoby E; Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Martin PL; Division of Pediatric and Cellular Therapy, Duke University Medical Center, Durham, North Carolina, USA., Parikh SB; Center for Pediatric Neurosciences, Mitochondrial Medicine, Cleveland Clinic, Cleveland, Ohio, USA., Fleming MD; Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Agarwal S; Division of Hematology/Oncology and Stem Cell Program, Boston Children's Hospital, Boston, Massachusetts, USA.; Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Harvard Stem Cell Institute, Harvard Initiative in RNA Medicine, Boston, Massachusetts, USA.; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.

Publikováno v: American journal of hematology [Am J Hematol] 2023 Dec; Vol. 98 (12), pp. E376-E379. Date of Electronic Publication: 2023 Sep 21.

On the illusion of auxotrophy: met15Δ yeast cells can grow on inorganic sulfur, thanks to the previously uncharacterized homocysteine synthase Yll058w.

Autor: Van Oss SB; Department of Computational and System Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Pittsburgh Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Parikh SB; Department of Computational and System Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Pittsburgh Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Castilho Coelho N; Department of Computational and System Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Pittsburgh Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Wacholder A; Department of Computational and System Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Pittsburgh Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Belashov I; Department of Biological Sciences, University of Pittsburgh, Dietrich School of Arts & Sciences, Pittsburgh, Pennsylvania, USA., Zdancewicz S; Department of Biological Sciences, University of Pittsburgh, Dietrich School of Arts & Sciences, Pittsburgh, Pennsylvania, USA., Michaca M; Department of Computational and System Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Pittsburgh Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Xu J; Department of Computational and System Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Kang YP; Department of Cancer Physiology, H. Lee Moffitt Cancer Center, Tampa, Florida, USA., Ward NP; Department of Cancer Physiology, H. Lee Moffitt Cancer Center, Tampa, Florida, USA., Yoon SJ; Department of Cancer Physiology, H. Lee Moffitt Cancer Center, Tampa, Florida, USA., McCourt KM; Department of Computational and System Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Pittsburgh Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., McKee J; Department of Computational and System Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Ideker T; Departments of Medicine, Bioengineering, Computer Science and Engineering, Institute for Genomic Medicine, University of California San Diego, La Jolla, California, USA., VanDemark AP; Department of Biological Sciences, University of Pittsburgh, Dietrich School of Arts & Sciences, Pittsburgh, Pennsylvania, USA., DeNicola GM; Department of Cancer Physiology, H. Lee Moffitt Cancer Center, Tampa, Florida, USA., Carvunis AR; Department of Computational and System Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Pittsburgh Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address: anc201@pitt.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2022 Dec; Vol. 298 (12), pp. 102697. Date of Electronic Publication: 2022 Nov 13.

LI Detector: a framework for sensitive colony-based screens regardless of the distribution of fitness effects.

Autor: Parikh SB; Department of Computational and Systems Biology, Pittsburgh Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Castilho Coelho N; Department of Computational and Systems Biology, Pittsburgh Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA., Carvunis AR; Department of Computational and Systems Biology, Pittsburgh Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Publikováno v: G3 (Bethesda, Md.) [G3 (Bethesda)] 2021 Feb 09; Vol. 11 (2).

De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences.

Autor: Vakirlis N; Smurfit Institute of Genetics, Trinity College Dublin, University of Dublin, Dublin, 2, Ireland., Acar O; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, United States.; Pittsburgh Center for Evolutionary Biology and Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, United States., Hsu B; Department of Medicine, Division of Medical Genetics, University of California San Diego, La Jolla, CA, 92093, United States., Castilho Coelho N; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, United States.; Pittsburgh Center for Evolutionary Biology and Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, United States., Van Oss SB; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, United States.; Pittsburgh Center for Evolutionary Biology and Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, United States., Wacholder A; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, United States.; Pittsburgh Center for Evolutionary Biology and Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, United States., Medetgul-Ernar K; Department of Medicine, Division of Medical Genetics, University of California San Diego, La Jolla, CA, 92093, United States., Bowman RW 2nd; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, 15260, United States., Hines CP; Department of Medicine, Division of Medical Genetics, University of California San Diego, La Jolla, CA, 92093, United States., Iannotta J; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, United States.; Pittsburgh Center for Evolutionary Biology and Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, United States., Parikh SB; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, United States.; Pittsburgh Center for Evolutionary Biology and Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, United States., McLysaght A; Smurfit Institute of Genetics, Trinity College Dublin, University of Dublin, Dublin, 2, Ireland., Camacho CJ; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, United States., O'Donnell AF; Pittsburgh Center for Evolutionary Biology and Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, United States. allyod@pitt.edu.; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, 15260, United States. allyod@pitt.edu., Ideker T; Department of Medicine, Division of Medical Genetics, University of California San Diego, La Jolla, CA, 92093, United States. tideker@ad.ucsd.edu., Carvunis AR; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, United States. anc201@pitt.edu.; Pittsburgh Center for Evolutionary Biology and Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, United States. anc201@pitt.edu.

Publikováno v: Nature communications [Nat Commun] 2020 Feb 07; Vol. 11 (1), pp. 781. Date of Electronic Publication: 2020 Feb 07.