Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Parijat Senapati"'
Autor:
Heon Shin, Amy Leung, Kevin R Costello, Parijat Senapati, Hiroyuki Kato, Roger E Moore, Michael Lee, Dimitri Lin, Xiaofang Tang, Patrick Pirrotte, Zhen Bouman Chen, Dustin E Schones
Publikováno v:
eLife, Vol 12 (2023)
The DNA methyltransferase activity of DNMT1 is vital for genomic maintenance of DNA methylation. We report here that DNMT1 function is regulated by O-GlcNAcylation, a protein modification that is sensitive to glucose levels, and that elevated O-GlcNA
Externí odkaz:
https://doaj.org/article/01fe54536d654e7bb305f7fb4ed7dac4
Autor:
Mari B. Ishak Gabra, Ying Yang, Haiqing Li, Parijat Senapati, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran, Lishi Zhang, Linda T. Doan, Xiangdong Xu, Dustin E. Schones, David A. Fruman, Mei Kong
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The availability of nutrients within the tumour microenvironment can influence tumour growth. Here, the authors find that, in a melanoma mouse model, mice fed a high glutamine diet have reduced tumour growth, increased sensitivity to Braf inhibitors
Externí odkaz:
https://doaj.org/article/f55f7d0478ab4cf7851235354cd349ce
Autor:
Parijat Senapati, Hiroyuki Kato, Michael Lee, Amy Leung, Christine Thai, Angelica Sanchez, Emily J. Gallagher, Derek LeRoith, Victoria L. Seewaldt, David K. Ann, Dustin E. Schones
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-15 (2019)
Abstract Background Hyperinsulinemia, the presence of excess insulin relative to glucose in the blood, is considered to be a poor prognostic indicator for patients with triple-negative breast cancer (TNBC). mTOR, a downstream effector of insulin, enh
Externí odkaz:
https://doaj.org/article/d7335b0fd4b044189496f088802659ef
Autor:
Sadhan Das, Parijat Senapati, Zhuo Chen, Marpadga A. Reddy, Rituparna Ganguly, Linda Lanting, Varun Mandi, Anita Bansal, Amy Leung, Selena Zhang, Ye Jia, Xiwei Wu, Dustin E. Schones, Rama Natarajan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
The repertoire of tissue-specific distal regulators of gene transcription enhancers defines homeostasis or disease. Here, the authors reveal the enhancer and super-enhancer signature of vascular smooth muscle cells under normal and angiotensin II sti
Externí odkaz:
https://doaj.org/article/c12c799c38c64e36a32adeb8061e24ec
Autor:
Parijat Majumder, Amrita Banerjee, Jayasha Shandilya, Parijat Senapati, Snehajyoti Chatterjee, Tapas K Kundu, Dipak Dasgupta
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57693 (2013)
The condensed structure of chromatin limits access of cellular machinery towards template DNA. This in turn represses essential processes like transcription, replication, repair and recombination. The repression is alleviated by a variety of energy d
Externí odkaz:
https://doaj.org/article/65891f43981448aaae46fff8dee0b8a7
Autor:
Erez Dror, Luca Fagnocchi, Vanessa Wegert, Stefanos Apostle, Brooke Grimaldi, Tim Gruber, Ilaria Panzeri, Steffen Heyne, Kira Daniela Höffler, Victor Kreiner, Reagan Ching, Tess Tsai-Hsiu Lu, Ayush Semwal, Ben Johnson, Parijat Senapati, Adelheid M. Lempradl, Dustin Schones, Axel Imhof, Hui Shen, John Andrew Pospisilik
SummaryDespite the recent explosion in surveys of cell-type heterogeneity, the mechanisms that specify and stabilize highly related cell subtypes remain poorly understood. Here, focusing initially on exploring quantitative histone mark heterogeneity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7028eb9f51ed045ac9f9fec222983a4d
https://doi.org/10.1101/2023.01.31.526222
https://doi.org/10.1101/2023.01.31.526222
Publikováno v:
Sub-cellular biochemistry. 100
Lysine acetylation is the second most well-studied post-translational modification after phosphorylation. While phosphorylation regulates signaling cascades, one of the most significant roles of acetylation is regulation of chromatin structure. Acety
Autor:
Rosalyn W. Sayaman, Masaru Miyano, Parijat Senapati, Arrianna Zirbes, Sundus Shalabi, Michael E. Todhunter, Victoria Seewaldt, Susan L. Neuhausen, Martha R. Stampfer, Dustin E. Schones, Mark A. LaBarge
Effects from aging in single cells are unpredictable, whereas aging phenotypes at the organ- and tissue-levels tend to appear as stereotypical changes. The mammary epithelium is a bilayer of two major phenotypically and functionally distinct cell lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d0d32e931fb1e11848bf19692a235a6
https://doi.org/10.1101/2022.09.22.509091
https://doi.org/10.1101/2022.09.22.509091
Autor:
Parijat Senapati, Aditya Bhattacharya, Sadhan Das, Suchismita Dey, Deepthi Sudarshan, Shyla G, Jyoti Vishwakarma, Surabhi Sudevan, Ravishankar Ramachandran, Tessy Thomas Maliekal, Tapas K. Kundu
Publikováno v:
Mol Cell Biol
Nucleophosmin (NPM1) is a multifunctional histone chaperone that can activate acetylation-dependent transcription from chromatin templates in vitro. p300-mediated acetylation of NPM1 has been shown to further enhance its transcription activation pote
Autor:
Masaru Miyano, Rosalyn W. Sayaman, Parijat Senapati, Stefan Hinz, Victoria E. Seewaldt, Dustin Schones, Mark A. LaBarge
Publikováno v:
Cancer Research. 83:PR006-PR006
Effects from aging in any single cell are unpredictable, whereas aging phenotypes at the organ and tissue levels tend to appear as stereotypical changes. The mammary epithelium, the origin of breast carcinomas, is a bilayer of two major phenotypicall