Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Parijat, Kabiraj"'
Autor:
Parijat Kabiraj, Ethan M. Grund, Benjamin D. S. Clarkson, Renee K. Johnson, Reghann G. LaFrance-Corey, Claudia F. Lucchinetti, Charles L. Howe
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Astrocytes utilize both glycolytic and mitochondrial pathways to power cellular processes that are vital to maintaining normal CNS functions. These cells also mount inflammatory and acute phase reactive programs in response to diverse stimul
Externí odkaz:
https://doaj.org/article/6082d9204e764fd28bf335baa7845997
Autor:
Rachel A Battaglia, Adriana S Beltran, Samed Delic, Raluca Dumitru, Jasmine A Robinson, Parijat Kabiraj, Laura E Herring, Victoria J Madden, Namritha Ravinder, Erik Willems, Rhonda A Newman, Roy A Quinlan, James E Goldman, Ming-Der Perng, Masaki Inagaki, Natasha T Snider
Publikováno v:
eLife, Vol 8 (2019)
Alexander disease (AxD) is a fatal neurodegenerative disorder caused by mutations in glial fibrillary acidic protein (GFAP), which supports the structural integrity of astrocytes. Over 70 GFAP missense mutations cause AxD, but the mechanism linking d
Externí odkaz:
https://doaj.org/article/1a944b07b95f440191c0e5f0e38980a8
Autor:
Parijat Kabiraj, Charles L. Howe, Claudia F. Lucchinetti, W. Oliver Tobin, Christina B. McCarthy, Jordan Wilkins, Oleksandr Gakh
Publikováno v:
Aging (Albany NY)
Multiple sclerosis (MS) is a central nervous system inflammatory demyelinating disease and the most common cause of non-traumatic disability in young adults. Despite progress in the treatment of the active relapsing disease, therapeutic options targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2f87d92dc9e5bee80b6a3ed34ca24c
https://doi.org/10.18632/aging.103612
https://doi.org/10.18632/aging.103612
Autor:
Samed Delic, Jasmine A. Robinson, Victoria J. Madden, Parijat Kabiraj, Laura E. Herring, James E. Goldman, Namritha Ravinder, Rhonda A. Newman, Roy A. Quinlan, Ming-Der Perng, Masaki Inagaki, Rachel A. Battaglia, Natasha T. Snider, Adriana S. Beltran, Erik Willems, Raluca Dumitru
Publikováno v:
eLife, 2019, Vol.8, pp.e47789 [Peer Reviewed Journal]
eLife
eLife, Vol 8 (2019)
eLife
eLife, Vol 8 (2019)
Alexander disease (AxD) is a fatal neurodegenerative disorder caused by mutations in glial fibrillary acidic protein (GFAP), which supports the structural integrity of astrocytes. Over 70 GFAP missense mutations cause AxD, but the mechanism linking d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cae63cfcc7b47b01b62ed8ceb291d57
https://doi.org/10.7554/elife.47789
https://doi.org/10.7554/elife.47789
Autor:
Surendra Dasari, K. Sreekumaran Nair, Patrick M. Vanderboom, Claudia F. Lucchinetti, Christina B. McCarthy, Gregory N. Ruegsegger, Katherine A. Klaus, Parijat Kabiraj
Insulin resistance associates with increased risk for cognitive decline and dementia; however, the underpinning mechanisms for this increased risk remain to be fully defined. As insulin resistance impairs mitochondrial oxidative metabolism and increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d340931138fd45ff5561fcefffbc8b3d
https://europepmc.org/articles/PMC6795285/
https://europepmc.org/articles/PMC6795285/
Autor:
Claudia F. Lucchinetti, W. Oliver Tobin, Parijat Kabiraj, Charles L. Howe, Oleksandr Gakh, Jordan Wilkins, Christina B. McCarthy
Publikováno v:
Aging. 13:7707-7707
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5499882f651d9ad3ed5a4ee50545658d
https://doi.org/10.18632/aging.202757
https://doi.org/10.18632/aging.202757
Autor:
Rachel A. Battaglia, Kathryn P. Trogden, Harald Herrmann, Parijat Kabiraj, Victoria J. Madden, Natasha T. Snider
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(5)
Vimentin is a cytoskeletal intermediate filament protein that is expressed in mesenchymal cells and cancer cells during the epithelial-mesenchymal transition. The goal of this study was to identify vimentin-targeting small molecules by using the Tocr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd856e61f61acfa0ef985362d6b0e8fa
https://pubmed.ncbi.nlm.nih.gov/29401610
https://pubmed.ncbi.nlm.nih.gov/29401610
Publikováno v:
Journal of Visualized Experiments.
Intermediate filaments (IFs), together with actin filaments and microtubules, form the cytoskeleton - a critical structural element of every cell. Normal functioning IFs provide cells with mechanical and stress resilience, while a dysfunctional IF cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6560d43118788b0bc8c5b0ae0e359228
https://doi.org/10.3791/55655
https://doi.org/10.3791/55655
Publikováno v:
Biochemical and Biophysical Research Communications. 426:438-444
Mitochondrial dysfunction, leading to elevated levels of reactive oxygen species, is associated with the pathogenesis of neurodegenerative disorders. Rotenone, a mitochondrial stressor induces caspase-9 and caspase-3 activation leading proteolytic cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d2150eb8e0f961fcb6e1ac39cab50a
https://doi.org/10.1016/j.bbrc.2012.08.121
https://doi.org/10.1016/j.bbrc.2012.08.121
Autor:
Karine Fénelon, Michael S. Hwang, Carlos A. Valenzuela, Jose Eduardo Marin, David A. Ramirez, Mahesh Narayan, Parijat Kabiraj, Armando Varela-Ramirez, Lois Mendez, Rachid Skouta
Publikováno v:
The protein journal. 34(5)
Endoplasmic reticulum (ER) proteins including protein disulfide isomerase (PDI) are playing crucial roles in maintaining appropriate protein folding. Under nitrosative stress, an excess of nitric oxide (NO) radical species induced the S-nitrosylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84f6967ddd89a01cf857533b821e2266
https://pubmed.ncbi.nlm.nih.gov/26385697
https://pubmed.ncbi.nlm.nih.gov/26385697