Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Paride Liscio"'
Autor:
Michele Cianci, Nicola Giacchè, Lucia Cialabrini, Andrea Carotti, Paride Liscio, Emiliano Rosatelli, Francesca De Franco, Massimiliano Gasparrini, Janet Robertson, Adolfo Amici, Nadia Raffaelli, Roberto Pellicciari
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) stands at a branch point of the de novo NAD+ synthesis pathway and plays an important role in maintaining NAD+ homeostasis. It has been recently identified as a novel therapeutic
Externí odkaz:
https://doaj.org/article/939b4944020c4a4f9cf2c164cbbc4724
Autor:
Marika Zietak, Roberto Pellicciari, Nicola Giacchè, Lucia Cialabrini, Adrienne Mottis, Vera van der Velpen, Elena Katsyuba, Nadia Raffaelli, Paride Liscio, Nadine Stokar-Regenscheit, Johan Auwerx, Julijana Ivanisevic, David Legouis, Kristina Schoonjans, Karim Gariani, Francesca De Franco, Sophie de Seigneux, Olli Matilainen, Dongryeol Ryu
Publikováno v:
Nature
Nature, vol. 563, no. 7731, pp. 354-359
Nature, Vol. 563, No 7731 (2018) pp. 354-359
Nature, vol. 563, no. 7731, pp. 354-359
Nature, Vol. 563, No 7731 (2018) pp. 354-359
Nicotinamide adenine dinucleotide (NAD + ) is a co-substrate for several enzymes, including the sirtuin family of NAD + -dependent protein deacylases. Beneficial effects of increased NAD + levels and sirtuin activation on mitochondrial homeostasis, o
Autor:
Roccaldo Sardella, Stefania Asciutti, Paride Liscio, Andrea Carotti, Emidio Camaioni, Antonio Macchiarulo, Martina Ferri
Publikováno v:
European Journal of Medicinal Chemistry. 142:506-522
Recent years have seen substantially heightened interest in the discovery of tankyrase inhibitors (TNKSi) as new promising anticancer agents. In this framework, the aim of this review article is focused on the description of potent TNKSi also endowed
Autor:
Manuel Alunno, Francesco Antonio Greco, Emidio Camaioni, Andrea Carotti, Giorgio Saluti, Roccaldo Sardella, Paride Liscio, Antonio Macchiarulo, Andrea Mammoli, Martina Ferri
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115731
The medicinal chemist toolbox is plenty of (bio)isosteres when looking for a carboxylic acid replacement. However, systematic assessment of acid surrogates is often time consuming and expensive, while prediction of both physicochemical properties (lo
Autor:
Johan Auwerx, Janet Robertson, Francesca De Franco, Andrea Carotti, Paride Liscio, Nicola Giacchè, Elena Katsyuba, Roberto Pellicciari, Lucia Cialabrini, Nadia Raffaelli
Publikováno v:
Journal of medicinal chemistry. 61(3)
NAD+ has a central function in linking cellular metabolism to major cell-signaling and gene-regulation pathways. Defects in NAD+ homeostasis underpin a wide range of diseases, including cancer, metabolic disorders, and aging. Although the beneficial
Autor:
Elena, Katsyuba, Adrienne, Mottis, Marika, Zietak, Francesca, De Franco, Vera, van der Velpen, Karim, Gariani, Dongryeol, Ryu, Lucia, Cialabrini, Olli, Matilainen, Paride, Liscio, Nicola, Giacchè, Nadine, Stokar-Regenscheit, David, Legouis, Sophie, de Seigneux, Julijana, Ivanisevic, Nadia, Raffaelli, Kristina, Schoonjans, Roberto, Pellicciari, Johan, Auwerx
Publikováno v:
Nature. 563(7731)
Nicotinamide adenine dinucleotide (NAD
Autor:
Laura Llacuna, Stefania Asciutti, Tobias Karlberg, Roberto Pellicciari, Andrea Carotti, Daniele Bellocchi, Emidio Camaioni, Herwig Schüler, Paride Liscio, Stuart A. Aaronson, Antonio Macchiarulo
Publikováno v:
Journal of Medicinal Chemistry. 57:2807-2812
Searching for selective tankyrases (TNKSs) inhibitors, a new small series of 6,8-disubstituted triazolo[4,3-b]piridazines has been synthesized and characterized biologically. Structure-based optimization of the starting hit compound NNL (3) prompted
Autor:
Emidio Camaioni, Martina Ferri, Antimo Gioiello, Nicola Giacchè, Daniela Passeri, Antonio Macchiarulo, Andrea Carotti, Paola Sabbatini, Roberto Pellicciari, Paride Liscio
Publikováno v:
ChemInform. 47
Recent years have witnessed a renewed interest in PARP-1 inhibitors as promising anticancer agents with multifaceted functions. Particularly exciting developments include the approval of olaparib (Lynparza) for the treatment of refractory ovarian can
Autor:
Antonio Macchiarulo, Paride Liscio, Andrea Carotti, Daniela Passeri, Roberto Pellicciari, Emidio Camaioni, Antimo Gioiello, Nicola Giacchè, Martina Ferri, Paola Sabbatini
Recent years have witnessed a renewed interest in PARP-1 inhibitors as promising anticancer agents with multifaceted functions. Particularly exciting developments include the approval of olaparib (Lynparza) for the treatment of refractory ovarian can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa437ff6eca3ac5bfd5ab96e493d133
http://hdl.handle.net/11391/1366098
http://hdl.handle.net/11391/1366098
Autor:
Roberto Pellicciari, Emidio Camaioni, Stefania Asciutti, Sara Valloscuro, Neil R. Clark, Antonio Macchiarulo, Jacob Ziff, Andrea Carotti, Stuart A. Aaronson, Martina Ferri, Paride Liscio, Maira M. Pires
Publikováno v:
European journal of medicinal chemistry. 87
A virtual screening procedure was applied to identify new tankyrase inhibitors. Through pharmacophore screening of a compounds collection from the SPECS database, the methoxy[l]benzothieno[2,3-c]quinolin-6(5H)-one scaffold was identified as nicotinam