scMuffin: an R package to disentangle solid tumor heterogeneity by single-cell gene expression analysis

Autor: Valentina Nale, Alice Chiodi, Noemi Di Nanni, Ingrid Cifola, Marco Moscatelli, Cinzia Cocola, Matteo Gnocchi, Eleonora Piscitelli, Ada Sula, Ileana Zucchi, Rolland Reinbold, Luciano Milanesi, Alessandra Mezzelani, Paride Pelucchi, Ettore Mosca

Publikováno v: BMC Bioinformatics, Vol 24, Iss 1, Pp 1-18 (2023)

Abstract Introduction Single-cell (SC) gene expression analysis is crucial to dissect the complex cellular heterogeneity of solid tumors, which is one of the main obstacles for the development of effective cancer treatments. Such tumors typically con

Externí odkaz: https://doaj.org/article/f5fb666a746d4a0c9efa37c72f66cf11

Generation of two hiPSC lines (UMILi027-A and UMILi028-A) from early and late-onset Congenital Central hypoventilation Syndrome (CCHS) patients carrying a polyalanine expansion mutation in the PHOX2B gene

Autor: Ana Lucia Cuadros Gamboa, Roberta Benfante, Monica Nizzardo, Tiziana Bachetti, Paride Pelucchi, Valentina Melzi, Cinzia Arzilli, Marta Peruzzi, Rolland A. Reinbold, Silvia Cardani, Amelia Morrone, Renzo Guerrini, Ileana Zucchi, Stefania Corti, Isabella Ceccherini, Raffaele Piumelli, Niccolò Nassi, Simona Di Lascio, Diego Fornasari

Publikováno v: Stem Cell Research, Vol 61, Iss , Pp 102781- (2022)

Congenital Central Hypoventilation Syndrome (CCHS) is a rare disorder of the autonomic nervous system (ANS), characterized by inadequate control of autonomic ventilation and global autonomic dysfunction. Heterozygous polyalanine repeat expansion muta

Externí odkaz: https://doaj.org/article/aaf7a82787834f39b8f3ea00ebf56a91

The Heparan Sulfate Sulfotransferases HS2ST1 and HS3ST2 Are Novel Regulators of Breast Cancer Stem-Cell Properties

Autor: Felipe C. O. B. Teixeira, Archana Vijaya Kumar, Sampath Kumar Katakam, Cinzia Cocola, Paride Pelucchi, Monika Graf, Ludwig Kiesel, Rolland Reinbold, Mauro S. G. Pavão, Burkhard Greve, Martin Götte

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Heparan sulfate (HS) is a glycosaminoglycan found mainly in its protein-conjugated form at the cell surface and the extracellular matrix. Its high sulfation degree mediates functional interactions with positively charged amino acids in proteins. 2-O

Externí odkaz: https://doaj.org/article/670d6cb63448476f98ff5f095c288aa4

scMuffin: an R package for resolving solid tumor heterogeneity from single-cell expression data

Autor: Valentina Nale, Noemi Di Nanni, Alice Chiodi, Ingrid Cifola, Marco Moscatelli, Cinzia Cocola, Matteo Gnocchi, Eleonora Piscitelli, Rolland Reinbold, Ileana Zucchi, Luciano Milanesi, Alessandra Mezzelani, Paride Pelucchi, Ettore Mosca

INTRODUCTIONSingle-cell (SC) gene expression analysis is crucial to dissect the complex cellular heterogeneity of solid tumors, which is one of the main obstacles for the development of effective cancer treatments. Such tumors typically contain a mix

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3539699260bdde91e39ffd6ed98028c3
https://doi.org/10.1101/2022.06.01.494129

The heparan sulfate proteoglycan syndecan‐1 regulates colon cancer stem cell function via a focal adhesion kinase—Wnt signaling axis

Autor: Valeria Tria, Rolland Reinbold, George W. Yip, Wey-Cheng Sim, Sherif Abdelaziz Ibrahim, Ileana Zucchi, Burkhard Greve, Sampath Kumar Katakam, Theodoros Karnavas, Martin Götte, Stefano Molgora, Paride Pelucchi, Eleonora Piscitelli, Eslam A. El-Ghonaimy

Publikováno v: The FEBS Journal
The FEBS journal
(2020). doi:10.1111/febs.15356
info:cnr-pdr/source/autori:Katakam, Sampath Kumar; Tria, Valeria; Sim, Wey-Cheng; Yip, George W.; Molgora, Stefano; Karnavas, Theodoros; Elghonaimy, Eslam A.; Pelucchi, Paride; Piscitelli, Eleonora; Ibrahim, Sherif Abdelaziz; Zucchi, Ileana; Reinbold, Rolland; Greve, Burkhard; Goette, Martin/titolo:The heparan sulfate proteoglycan syndecan-1 regulates colon cancer stem cell function via a focal adhesion kinase-Wnt signaling axis/doi:10.1111%2Ffebs.15356/rivista:The FEBS journal (Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume

In colon cancer, downregulation of the transmembrane heparan sulfate proteoglycan syndecan-1 (Sdc-1) is associated with increased invasiveness, metastasis, and dedifferentiation. As Sdc-1 modulates signaling pathways relevant to stem cell function, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ea4b24fab851ea7f018baf542f61c0
https://doi.org/10.1111/febs.15356