Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD.

Autor: Gandal MJ; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. michael.gandal@pennmedicine.upenn.edu.; Center for Autism Research and Treatment, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA. michael.gandal@pennmedicine.upenn.edu.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. michael.gandal@pennmedicine.upenn.edu.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. michael.gandal@pennmedicine.upenn.edu.; Lifespan Brain Institute at Penn Medicine and The Children's Hospital of Philadelphia, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA. michael.gandal@pennmedicine.upenn.edu., Haney JR; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Center for Autism Research and Treatment, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Wamsley B; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Center for Autism Research and Treatment, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Yap CX; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Mater Research Institute, University of Queensland, Brisbane, Queensland, Australia.; Institute for Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia., Parhami S; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Center for Autism Research and Treatment, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Emani PS; Computational Biology & Bioinformatics Program, Yale University, New Haven, CT, USA., Chang N; Computational Biology & Bioinformatics Program, Yale University, New Haven, CT, USA., Chen GT; Center for Autism Research and Treatment, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Hoftman GD; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., de Alba D; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Ramaswami G; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Center for Autism Research and Treatment, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA., Hartl CL; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Center for Autism Research and Treatment, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA., Bhattacharya A; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Luo C; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Jin T; Waisman Center and Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA., Wang D; Waisman Center and Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA., Kawaguchi R; Center for Autism Research and Treatment, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA., Quintero D; Center for Autism Research and Treatment, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA., Ou J; Center for Autism Research and Treatment, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA., Wu YE; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Center for Autism Research and Treatment, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA., Parikshak NN; Center for Autism Research and Treatment, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Swarup V; Center for Autism Research and Treatment, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA., Belgard TG; The Bioinformatics CRO, Niceville, FL, USA., Gerstein M; Computational Biology & Bioinformatics Program, Yale University, New Haven, CT, USA., Pasaniuc B; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Geschwind DH; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. dhg@mednet.ucla.edu.; Center for Autism Research and Treatment, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA. dhg@mednet.ucla.edu.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. dhg@mednet.ucla.edu.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. dhg@mednet.ucla.edu.; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. dhg@mednet.ucla.edu.

Publikováno v: Nature [Nature] 2022 Nov; Vol. 611 (7936), pp. 532-539. Date of Electronic Publication: 2022 Nov 02.

A 3D approach to understanding heterogeneity in early developing autisms.

Autor: Mandelli, Veronica¹ (AUTHOR), Severino, Ines^1,2 (AUTHOR), Eyler, Lisa^3,4 (AUTHOR), Pierce, Karen⁵ (AUTHOR), Courchesne, Eric⁵ (AUTHOR), Lombardo, Michael V.¹ (AUTHOR) michael.lombardo@iit.it

Publikováno v: Molecular Autism. 9/30/2024, Vol. 15 Issue 1, p1-16. 16p.

Banking on Polygenicity to Disentangle Psychiatric Comorbidity.

Autor: Haney JR; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, and the Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California., Parhami S; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, and the Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California., Gandal MJ; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, and the Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California. Electronic address: mgandal@mednet.ucla.edu.

Publikováno v: Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2018 Jul; Vol. 3 (7), pp. 577-578.

Relationship between sex biases in gene expression and sex biases in autism and Alzheimer's disease.

Autor: Fass, Stuart B.^1,2 (AUTHOR), Mulvey, Bernard^1,2,3 (AUTHOR), Chase, Rebecca^1,2 (AUTHOR), Yang, Wei^1,4 (AUTHOR), Selmanovic, Din^1,2 (AUTHOR), Chaturvedi, Sneha M.^1,2 (AUTHOR), Tycksen, Eric^1,4 (AUTHOR), Weiss, Lauren A.^5,6,7 (AUTHOR), Dougherty, Joseph D.^1,2,8,9 (AUTHOR) jdougherty@wustl.edu

Publikováno v: Biology of Sex Differences. 6/7/2024, Vol. 15 Issue 1, p1-20. 20p.

Batch correction and harmonization of -Omics datasets with a tunable median polish of ratio.

Autor: Dammer, Eric B.^1,2 edammer@emory.edu, Seyfried, Nicholas T.^1,2,3, Johnson, Erik C. B.^1,3

Publikováno v: Frontiers in Systems Biology. 2024, p1-15. 15p.