Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Paresh P, Chothe"'
Autor:
Flavia Storelli, Mayur K. Ladumor, Xiaomin Liang, Yurong Lai, Paresh P. Chothe, Osatohanmwen J. Enogieru, Raymond Evers, Jashvant D. Unadkat
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 1, Pp 118-131 (2024)
Abstract Hepatic impairment (HI) moderately (10‐fold) for drugs that are also substrates of cytochrome P450 (CYP) 3A enzymes. Using the extended clearance model, through simulations, we identified the ratio of sinusoidal efflux clearance (CL) over
Externí odkaz:
https://doaj.org/article/c097d02f10554901a6c847d7d9e18162
Autor:
Mayur K. Ladumor, Flavia Storelli, Xiaomin Liang, Yurong Lai, Osatohanmwen J. Enogieru, Paresh P. Chothe, Raymond Evers, Jashvant D. Unadkat
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 2, Pp 261-273 (2023)
Abstract Physiologically based pharmacokinetic models, populated with drug‐metabolizing enzyme and transporter (DMET) abundance, can be used to predict the impact of hepatic impairment (HI) on the pharmacokinetics (PK) of drugs. To increase confide
Externí odkaz:
https://doaj.org/article/c46951343ed24a8cbfdc20b789315bfd
Autor:
Mayur K. Ladumor, Flavia Storelli, Xiaomin Liang, Yurong Lai, Osatohanmwen J. Enogieru, Paresh P. Chothe, Raymond Evers, Jashvant D. Unadkat
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 12:261-273
Physiologically based pharmacokinetic models, populated with drug-metabolizing enzyme and transporter (DMET) abundance, can be used to predict the impact of hepatic impairment (HI) on the pharmacokinetics (PK) of drugs. To increase confidence in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5fc28686d8078da062e80b2c4f9e96
https://doi.org/10.1002/psp4.12901
https://doi.org/10.1002/psp4.12901
Autor:
Paresh P. Chothe, Pallabi Mitra, Masanori Nakakariya, Diane Ramsden, Charles J. Rotter, Philip Sandoval, Kimio Tohyama
Publikováno v:
Drug Metabolism Reviews. 54:299-317
On behalf of the team I am pleased to present the second annual 'novel insights into drug transporter sciences review' focused on peer-reviewed articles that were published in the year 2021. In compiling the articles for inclusion, preprints availabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a028bb269c4a20a1ee02fa8fec23157
https://doi.org/10.1080/03602532.2022.2094944
https://doi.org/10.1080/03602532.2022.2094944
Publikováno v:
Drug Metabolism Reviews. 53:321-349
Drug Metabolism Reviews has an impressive track record of providing scientific reviews in the area of xenobiotic biotransformation over 47 years. It has consistently proved to be resourceful to many scientists from pharmaceutical industry, academia,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3e6b9b6b82d126ba3a0370336b2b06
https://doi.org/10.1080/03602532.2021.1963270
https://doi.org/10.1080/03602532.2021.1963270
Autor:
Philip, Sandoval, Bei-Ching, Chuang, John K, Fallon, Philip C, Smith, Swapan K, Chowdhury, Robert J, Griffin, Cindy Q, Xia, Shinji, Iwasaki, Paresh P, Chothe
Publikováno v:
The AAPS journal. 24(6)
The liver is central to the elimination of many drugs from the body involving multiple processes and understanding of these processes is important to quantitively assess hepatic clearance of drugs. The synthetic STING (STimulator of INterferon Genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a26f47579196577f58f52183c4d0089
https://pubmed.ncbi.nlm.nih.gov/36123502
https://pubmed.ncbi.nlm.nih.gov/36123502
Publikováno v:
Drug Metabolism and Disposition. 49:314-321
The mechanistic understanding of bile salt disposition is not well established in suspension human hepatocytes (SHH) because of the limited information on the expression and function of bile salt export protein (BSEP) in this system. We investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922f4fb3e86f85305e85a7edc6987047
https://doi.org/10.1124/dmd.120.000057
https://doi.org/10.1124/dmd.120.000057
Autor:
Flavia Storelli, Mengyue Yin, Aditya R. Kumar, Mayur K. Ladumor, Raymond Evers, Paresh P. Chothe, Osatohanmwen J. Enogieru, Xiaomin Liang, Yurong Lai, Jashvant D. Unadkat
Publikováno v:
Pharmacology & Therapeutics. 238:108271
Predicting transporter-based drug clearance (CL) and tissue concentrations (TC) in humans is important to reduce the risk of failure during drug development. In addition, when transporters are present at the tissue:blood interface (e.g., in the liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f667706a2439ebd33ac63a8d66caee63
https://doi.org/10.1016/j.pharmthera.2022.108271
https://doi.org/10.1016/j.pharmthera.2022.108271
Publikováno v:
Molecular Pharmaceutics. 16:3569-3576
The human apical sodium-dependent bile acid transporter (hASBT; SLC10A2) is responsible for the reclamation of bile acids from the intestinal lumen, providing a primary mechanism for bile acid and cholesterol homeostasis. However, the regulation of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b3a5efb40987b310aa9b7741abf4e3e
https://doi.org/10.1021/acs.molpharmaceut.9b00426
https://doi.org/10.1021/acs.molpharmaceut.9b00426
Autor:
Philip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W. Yucha, Swapan K Chowdhury, Paresh P. Chothe
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 50(7)
Quantitative assessment of hepatic clearance (CL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8de9e5d222588a1c44038f7389db84d
https://pubmed.ncbi.nlm.nih.gov/35545257
https://pubmed.ncbi.nlm.nih.gov/35545257