Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Paresh A Malhotra"'
Autor:
Michael C B David, Magdalena Kolanko, Martina Del Giovane, Helen Lai, Jessica True, Emily Beal, Lucia M Li, Ramin Nilforooshan, Payam Barnaghi, Paresh A Malhotra, Helen Rostill, David Wingfield, Danielle Wilson, Sarah Daniels, David J Sharp, Gregory Scott
Publikováno v:
JMIR Aging, Vol 6, p e43777 (2023)
BackgroundInternet of Things (IoT) technology enables physiological measurements to be recorded at home from people living with dementia and monitored remotely. However, measurements from people with dementia in this context have not been previously
Externí odkaz:
https://doaj.org/article/9d853422e9e340b193627029624f910d
Autor:
Michael David, Paresh A. Malhotra
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 4, Pp 582-596 (2022)
Abstract There is clear, early noradrenergic dysfunction in Alzheimer's disease. This is likely secondary to pathological tau deposition in the locus coeruleus, the pontine nucleus that produces and releases noradrenaline, prior to involvement of cor
Externí odkaz:
https://doaj.org/article/026432796c90421394b290f4ff917fa2
Autor:
Benjamin Tari, Michael Ben Yehuda, Axel Anders Stefan Laurell, Karen Ritchie, Yves Dauvilliers, Craig Ritchie, Brian Lawlor, Lorina Naci, Graciela Muniz Terrera, Paresh A. Malhotra, Tam Watermeyer, Robert Dudas, Benjamin R. Underwood, John T. O’Brien, Vanessa Raymont, Ivan Koychev
IntroductionAs the global population ages, the economic, societal, and personal burdens associated with worsening cognition and dementia onset are growing. It is therefore becoming ever more critical to understand the factors associated with cognitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da4917a5788aa30ff196d650a5d63dbd
https://doi.org/10.1101/2023.05.18.23290160
https://doi.org/10.1101/2023.05.18.23290160
Autor:
Serena Verdi, Flavia Loreto, Seyed Mostafa Kia, Aleksandar Duvnjak, Haneen Hakeem, Richard J Perry, Zarni Win, Neva Patel, Jonathan M Schott, Andre F Marquand, Paresh A Malhotra, James H Cole
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Michael C B David, Martina Del Giovane, Kathy Y Liu, Benjamin Gostick, James Benedict Rowe, Imafidon Oboh, Robert Howard, Paresh A Malhotra
BackgroundDysfunction of the locus coeruleus-noradrenergic system occurs early in Alzheimer’s disease, contributing to cognitive and neuropsychiatric symptoms in some patients. This system offers a potential therapeutic target, although noradrenerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2370b488e09d60b4f598f786953c8e5c
Autor:
Marianna, Inglese, Neva, Patel, Kristofer, Linton-Reid, Flavia, Loreto, Zarni, Win, Richard J, Perry, Christopher, Carswell, Matthew, Grech-Sollars, William R, Crum, Haonan, Lu, Paresh A, Malhotra, Gail, Li
Alzheimer's disease, the most common cause of dementia, causes a progressive and irreversible deterioration of cognition that can sometimes be difficult to diagnose, leading to suboptimal patient care.We developed a predictive model that computes mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67aff9a1a3ef401d67561c90b2cfb339
http://hdl.handle.net/10044/1/97726
http://hdl.handle.net/10044/1/97726
Autor:
Karen Hoang, Hilary Watt, Mara Golemme, Richard J. Perry, Craig Ritchie, Danielle Wilson, James Pickett, Chris Fox, Robert Howard, Paresh A. Malhotra
Publikováno v:
Hoang, K, Watt, H, Golemme, M, Perry, R J, Ritchie, C, Wilson, D, Pickett, J, Fox, C, Howard, R & Malhotra, P A 2022, ' Noradrenergic Add-on Therapy with Extended-Release Guanfacine in Alzheimer's Disease (NorAD) : study protocol for a randomised clinical trial and COVID-19 amendments ', Trials, vol. 23, no. 1, pp. 623 . https://doi.org/10.1186/s13063-022-06190-3
Background Guanfacine is a α2A adrenergic receptor agonist approved for treating attention deficit hyperactivity disorder (ADHD). It is thought to act via postsynaptic receptors in the prefrontal cortex, modulating executive functions including the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e65dcca1482fde16f5cf4b017ab8e5
http://hdl.handle.net/10044/1/96348
http://hdl.handle.net/10044/1/96348
Autor:
Flavia Loreto, Anna Fitzgerald, Mara Golemme, Zarni Win, Neva Patel, Stephen Gunning, Anastasia Gontsarova, Angus Kennedy, Paul Edison, Christopher J Carswell, Richard J Perry, Paresh A Malhotra
Publikováno v:
Alzheimer's & Dementia. 17
Publikováno v:
Frontiers in Human Neuroscience, Vol 7 (2013)
The syndrome of spatial neglect results from the combination of a number of deficits in attention, with patients demonstrating both spatially lateralised and non-lateralised impairments. Previous reports have hinted that there may be a motivational c
Externí odkaz:
https://doaj.org/article/147265f227e64e16ba1d2f746c0c3115
Publikováno v:
Movement disorders : official journal of the Movement Disorder Society. 30(6)