Remote Monitoring of Physiology in People Living With Dementia: An Observational Cohort Study

Autor: Michael C B David, Magdalena Kolanko, Martina Del Giovane, Helen Lai, Jessica True, Emily Beal, Lucia M Li, Ramin Nilforooshan, Payam Barnaghi, Paresh A Malhotra, Helen Rostill, David Wingfield, Danielle Wilson, Sarah Daniels, David J Sharp, Gregory Scott

Publikováno v: JMIR Aging, Vol 6, p e43777 (2023)

BackgroundInternet of Things (IoT) technology enables physiological measurements to be recorded at home from people living with dementia and monitored remotely. However, measurements from people with dementia in this context have not been previously

Externí odkaz: https://doaj.org/article/9d853422e9e340b193627029624f910d

A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease

Autor: Marianna Inglese, Neva Patel, Kristofer Linton-Reid, Flavia Loreto, Zarni Win, Richard J. Perry, Christopher Carswell, Matthew Grech-Sollars, William R. Crum, Haonan Lu, Paresh A. Malhotra, the Alzheimer’s Disease Neuroimaging Initiative, Eric O. Aboagye

Publikováno v: Communications Medicine, Vol 2, Iss 1, Pp 1-16 (2022)

Inglese et al. develop a predictive model that computes multi-regional statistical morpho-functional mesoscopic traits from T1-weighted magnetic resonance imaging scans. Their model reliably discriminates people with Alzheimer’s disease-related pat

Externí odkaz: https://doaj.org/article/516c8e439e694aad9272b31dd5159e63

The indirect relationship between sleep and cognition in the PREVENT Cohort: Identifying targets for intervention

Autor: Benjamin Tari, Michael Ben Yehuda, Axel Anders Stefan Laurell, Karen Ritchie, Yves Dauvilliers, Craig Ritchie, Brian Lawlor, Lorina Naci, Graciela Muniz Terrera, Paresh A. Malhotra, Tam Watermeyer, Robert Dudas, Benjamin R. Underwood, John T. O’Brien, Vanessa Raymont, Ivan Koychev

IntroductionAs the global population ages, the economic, societal, and personal burdens associated with worsening cognition and dementia onset are growing. It is therefore becoming ever more critical to understand the factors associated with cognitiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da4917a5788aa30ff196d650a5d63dbd
https://doi.org/10.1101/2023.05.18.23290160

Cognitive and neuropsychiatric effects of noradrenergic treatment in Alzheimer's disease: systematic review and meta-analysis

Autor: Michael C B David, Martina Del Giovane, Kathy Y Liu, Benjamin Gostick, James Benedict Rowe, Imafidon Oboh, Robert Howard, Paresh A Malhotra

BackgroundDysfunction of the locus coeruleus-noradrenergic system occurs early in Alzheimer’s disease, contributing to cognitive and neuropsychiatric symptoms in some patients. This system offers a potential therapeutic target, although noradrenerg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2370b488e09d60b4f598f786953c8e5c

Noradrenergic add-on therapy with extended-release guanfacine in alzheimer’s disease: study protocol for a randomised clinical trial (NorAD) and COVID-19 amendments

Autor: Karen Hoang, Hilary Watt, Mara Golemme, Richard J. Perry, Craig Ritchie, Danielle Wilson, James Pickett, Chris Fox, Robert Howard, Paresh A. Malhotra

Publikováno v: Hoang, K, Watt, H, Golemme, M, Perry, R J, Ritchie, C, Wilson, D, Pickett, J, Fox, C, Howard, R & Malhotra, P A 2022, ' Noradrenergic Add-on Therapy with Extended-Release Guanfacine in Alzheimer's Disease (NorAD) : study protocol for a randomised clinical trial and COVID-19 amendments ', Trials, vol. 23, no. 1, pp. 623 . https://doi.org/10.1186/s13063-022-06190-3

Background Guanfacine is a α2A adrenergic receptor agonist approved for treating attention deficit hyperactivity disorder (ADHD). It is thought to act via postsynaptic receptors in the prefrontal cortex, modulating executive functions including the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e65dcca1482fde16f5cf4b017ab8e5
http://hdl.handle.net/10044/1/96348