Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Parekh, Tejal"'
Autor:
Parekh, Tejal1 tejalparekh@doctors.org.uk/tejal.parekh@pat.nhs.uk, Dodwell, David1, Sharma, Nisha1, Shaaban, Abeer M.1
Publikováno v:
Pathobiology. Sep2015, Vol. 82 Issue 3/4, p124-132. 9p.
Autor:
Weidong Pan, Prudence Bradley, Kevin X. Chen, Parekh Tejal N, Andrea Hart, Frank Bennett, Danial Prelusky, Srikanth Venkatraman, Robert Chase, Susan Bogdanowich-Knipp, Jianshe Kong, Bancha Vibulbhan, Viyyoor M. Girijavallabhan, Hendrata Siska, Rong Kong, Weiying Yang, Kuo-Chi Cheng, Ashit K. Ganguly, Nancy Butkiewicz, Ashok Arasappan, Yuhua Huang, Andrew Prongay, Bruce A. Malcolm, Xiang Liang, Rong Liu, Xiaoming Cui, Walter A. Korfmacher, Sony Agrawal, Wanli Wu, Zhuyan Guo, Stephane L. Bogen, Pike Russell E, Ronald E. White, Jesse Wong, Yi-Tsung Liu, Jean-Marc Brisson, John Pichardo, Anil K. Saksena, Pavlovsky Anastasia, Bahige M. Baroudy, F. George Njoroge, Vincent Madison, Patrick Pinto, Santhanam Bama, Raymond G. Lovey, Edwin Jao, Lisa Broske, Veljko Popov, Yunsheng Hsieh, Paul Ingravallo, Sumei Ruan, Piwinski John J
Publikováno v:
Journal of Medicinal Chemistry. 49:6074-6086
Hepatitis C virus (HCV) infection is the major cause of chronic liver disease, leading to cirrhosis and hepatocellular carcinoma, which affects more than 170 million people worldwide. Currently the only therapeutic regimens are subcutaneous interfero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b1025f20fc929de7fcc2e4ce1f01669
https://doi.org/10.1021/jm060325b
https://doi.org/10.1021/jm060325b
Autor:
Ashok Arasappan, Andrew Prongay, F. George Njoroge, Vincent Madison, Parekh Tejal N, Viyyoor M. Girijavallabhan, Nancy Butkiewicz, Kevin X. Chen, Srikanth Venkatraman, Haining Gu, John Pichardo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3960-3965
Synthesis and HCV NS3 serine protease inhibitory activity of 4-hydroxyproline derived macrocyclic inhibitors and SAR around this macrocyclic core is described in this communication. X-ray structure of inhibitor 38 bound to the protease is discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182ea8c68029bd73c06fcf909bd17b83
https://doi.org/10.1016/j.bmcl.2006.05.022
https://doi.org/10.1016/j.bmcl.2006.05.022
Autor:
Levy Odile Esther, B. Marten, Ashit K. Ganguly, Andrew Prongay, Patrick Pinto, Bruce A. Malcolm, Tin-Yau Chan, Parekh Tejal N, Santhanam Bama, Lim-Wilby Marguerita, Z. Zhu, Vincent Madison, Liwu Hong, Ashok Arasappan, Edwin Jao, Stephane L. Bogen, Hongwu Wang, Kemp Scott Jeffrey, F. G. Njoroge, Srikanth Venkatraman, Nanhua Yao, Kevin X. Chen, Nancy Butkiewicz, Mckittrick Brian A, John Pichardo, Henry M. Vaccaro, Liu Yi-Tsung, V. Girijavallabhan, Anil K. Saksena, Raymond G. Lovey, Richard N. Ingram, Haining Gu, Russell E. Pike, Frank Bennett, Xiaozheng Yang, Susan Y. Tamura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4180-4184
We have discovered that introduction of appropriate amino acid derivatives at P 2 ′ position improved the binding potency of P3-capped α-ketoamide inhibitors of HCV NS3 serine protease. X-ray crystal structure of one of the inhibitors (43) bound t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78f56ad19fec0b970200e58a9a29521e
https://doi.org/10.1016/j.bmcl.2005.06.091
https://doi.org/10.1016/j.bmcl.2005.06.091
Autor:
Viyyoor M. Girijavallabhan, Xiaozheng Yang, John Pichardo, Nanhua Yao, Parekh Tejal N, Nancy Butkiewicz, Andrew Prongay, F. George Njoroge, Ashok Arasappan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5751-5755
Synthesis and HCV NS3 serine protease inhibitory activity of some novel 2-oxoimidazolidine-4-carboxylic acid derivatives are reported. Inhibitors derived from this new P2 core exhibited activity in the low microM range. X-ray structure of an inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0945869d5b31672bd7ce3a6426bdbc71
https://doi.org/10.1016/j.bmcl.2004.09.058
https://doi.org/10.1016/j.bmcl.2004.09.058
Akademický článek
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Novel potent hepatitis C virus NS3 serine protease inhibitors derived from proline-based macrocycles
Autor:
Kuo-Chi Cheng, Kevin X. Chen, Andrew Prongay, Vincent Madison, Srikanth Venkatraman, Bancha Vibulbhan, Viyyoor M. Girijavallabhan, F. George Njoroge, Nancy Butkiewicz, Nanhua Yao, Weiying Yang, Parekh Tejal N, Ashok Arasappan, John Pichardo
Publikováno v:
Journal of medicinal chemistry. 49(3)
The hepatitis C virus (HCV) NS3 protease is essential for viral replication. It has been a target of choice for intensive drug discovery research. On the basis of an active pentapeptide inhibitor, 1, we envisioned that macrocyclization from the P2 pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f761f94bb0dd2bc86d6e0ae3eb70119e
https://pubmed.ncbi.nlm.nih.gov/16451065
https://pubmed.ncbi.nlm.nih.gov/16451065
Autor:
Kevin X. Chen, F. George Njoroge, Parekh Tejal N, Ashok Arasappan, Viyyoor M. Girijavallabhan
Publikováno v:
The Journal of organic chemistry. 67(11)
Dipeptide macrocycles of type A have been constructed in a versatile manner from the corresponding 4-heteroatom-substituted proline derivatives using an intramolecular Mitsunobu strategy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdae6cc544e7d9f4ca72680862b3efa
https://pubmed.ncbi.nlm.nih.gov/12027716
https://pubmed.ncbi.nlm.nih.gov/12027716
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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K zobrazení výsledku je třeba se přihlásit.
Autor:
Arasappan, Ashok, Njoroge, F. George, Chen, Kevin X., Venkatraman, Srikanth, Parekh, Tejal N., Gu, Haining, Pichardo, John, Butkiewicz, Nancy, Prongay, Andrew, Madison, Vincent, Girijavallabhan, Viyyoor
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2006 16(15):3960-3965