Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Pardeep Kaurah"'
Autor:
Glenwood D. Goss, Johanna N. Spaans, David Huntsman, Timothy Asmis, Natalie M. Andrews Wright, Marc Duciaume, Pardeep Kaurah, Ruth R. Miller, Shantanu Banerji, Harmanjatinder S. Sekhon, Marcio M. Gomes
Publikováno v:
Current Oncology, Vol 29, Iss 5, Pp 3171-3186 (2022)
Inuit are the Indigenous Arctic peoples and residents of the Canadian territory of Nunavut who have the highest global rate of lung cancer. Given lung cancer’s mortality, histological and genomic characterization was undertaken to better understand
Externí odkaz:
https://doaj.org/article/19fa4df936c2416ab987aef3528518a4
Autor:
Geoffrey, Roberts, Patrick R, Benusiglio, Tanya, Bisseling, Daniel, Coit, Jeremy L, Davis, Sam, Grimes, Theresa A, Guise, Richard, Hardwick, Kirsty, Harris, Paul Furman, Mansfield, Jeremy, Rossaak, Karen Chelcun, Schreiber, Peter P, Stanich, Vivian E, Strong, Pardeep, Kaurah, Sam, Yoon
Publikováno v:
Gastric Cancer, 25, 1094-1104
Gastric Cancer, 25, 6, pp. 1094-1104
Gastric Cancer, 25, 6, pp. 1094-1104
Item does not contain fulltext BACKGROUND: Prophylactic total gastrectomy (PTG) remains the only means of preventing gastric cancer for people with genetic mutations predisposing to Hereditary Diffuse Gastric Cancer (HDGC), mainly in the CDH1 gene. T
Autor:
Pardeep Kaurah, Magali Svrcek, Toshikazu Ushijima, James Whitworth, Yasmin Nouri, Kirsty L. Harris, Emily Schulpen, Jeremy L. Davis, Lynn DeGregorio, Hidetaka Yamada, Richard H. Hardwick, Tanis D Godwin, Julie Arnold, Carla Oliveira, Jolanda M. van Dieren, Helen L. Fisher, Bostjan Humar, Katharine Nichole Holm, Han Kwang Yang, Parry Guilford, Joana Figueiredo, Fátima Carneiro, Sonia S. Kupfer, Daniel G. Coit, Paul F. Mansfield, Andrew Latchford, Ana Sofia Ribeiro, Rebecca C. Fitzgerald, Anthony E. Reeve, Nicola Bougen-Zhukov, Patrick R. Benusiglio, Enrique Norero, Kimberley Gamet, Erin Gardner, Andrew A. Sporle, Patrícia Carneiro, Joao Sanches, Johanna L. D'Addario, Marc Tischkowitz, Maybelle McLeod, Tom Brew, Elizabeth C. Monroe, Alex Boussioutas, Rachel S. van der Post, Nicoline Hoogerbrugge, Mark D. Muller, Simone Busija, Haruhiko Sugimura, Irene Gullo, Tanya M. Bisseling, Karyn Paringatai, Liying Zhang, Joana Paredes, Raquel Seruca, David G. Huntsman, Karen E Chelcun Schreiber, James M. Ford, Jeremy Rossaak, Vanessa Blair, Amanda Charlton, Susan Parry, Takeshi Nakajima, Massimiliano di Pietro, C. J. Lintott, Adrian Claydon, Annemieke Cats
Publikováno v:
Lancet Oncology, 21, 8, pp. e386-e397
Lancet Oncol
Lancet Oncology, 21, e386-e397
Lancet Oncol
Lancet Oncology, 21, e386-e397
Contains fulltext : 225261.pdf (Publisher’s version ) (Closed access) Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is characterised by a high prevalence of diffuse gastric cancer and lobular breast cancer.
Autor:
Fernando Van Domselaar, Daniel Correa, Carlos Vaccaro, María Redal, Reinaldo Van Domselaar, David Huntsman, Pardeep Kaurah, Janine Senz, Henry Lynch
Publikováno v:
Acta Gastroenterológica Latinoamericana, Vol 37, Iss 3, Pp 158-163 (2007)
Introducción: el CGDH se hereda en forma autosómica dominante. Su sospecha se basa en los antecedentes familiares y su confirmación requiere estudios moleculares. En el 40% de las familias se logra identificar una mutación en el gen CDH1 de la ca
Externí odkaz:
https://doaj.org/article/bc50feaf7d7e4c72b718c6b0ebf3b18b
Autor:
Daniel Gaston, Samantha Hansford, Carla Oliveira, Mathew Nightingale, Hugo Pinheiro, Christine Macgillivray, Pardeep Kaurah, Andrea L Rideout, Patricia Steele, Gabriela Soares, Weei-Yuarn Huang, Scott Whitehouse, Sarah Blowers, Marissa A LeBlanc, Haiyan Jiang, Wenda Greer, Mark E Samuels, Andrew Orr, Conrad V Fernandez, Jacek Majewski, Mark Ludman, Sarah Dyack, Lynette S Penney, Christopher R McMaster, David Huntsman, Karen Bedard
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004669 (2014)
Gastric cancer is among the leading causes of cancer-related deaths worldwide. While heritable forms of gastric cancer are relatively rare, identifying the genes responsible for such cases can inform diagnosis and treatment for both hereditary and sp
Externí odkaz:
https://doaj.org/article/218c6627cf0742139b00ee32b9763ae2
Autor:
Kieran R Campbell, Monica Ta, Germain Ho, Tom Brew, Christine Chow, Dawn R. Cochrane, David G. Huntsman, David F. Schaeffer, Howard John Lim, Minh Bui, Parry Guilford, Steve E. Kalloger, Simon Cheung, David Farnell, Amal El-Naggar, Katherine Dixon, Pardeep Kaurah, Tanis D Godwin, J Maxwell Douglas
Publikováno v:
The Journal of pathologyReferences. 254(3)
Hereditary diffuse gastric cancer (HDGC) is a cancer syndrome caused by germline variants in CDH1, the gene encoding the cell-cell adhesion molecule E-cadherin. Loss of E-cadherin in cancer is associated with cellular dedifferentiation and poor progn
Publikováno v:
Gut
Although multiple demographic, environmental and genetic factors contribute to gastric cancer (GC) risk, familial clustering occurs in around 10%–15% of cases.1 A strong genetic predisposition underlies 1%–3%, with hereditary diffuse GC (HDGC) ac
Autor:
Pardeep Kaurah, Sam S. Yoon, I. Lewis, David G. Huntsman, K. Chelcun-Schreiber, Aline Talhouk, Andrée MacMillan
Publikováno v:
Fam Cancer
BACKGROUND: Germline CDH1 mutation carriers are at risk for early-onset diffuse gastric cancer (DGC) and female carriers have an additional risk of lobular breast cancer. The reported literature GC risk of 70% has led to the recommendation for germli
Autor:
John R. Goffin, Samantha Gray, Paul Wheatley-Price, Nevin Murray, Charles Butts, Normand Blais, Penelope A. Bradbury, Jenny Ko, Garth Nicholas, P. Brown-Walker, Scott A. Laurie, Marie Florescu, Jeffrey Rothenstein, Pardeep Kaurah, Cynthia Card, M. Neil Reaume, Dongsheng Tu, Leah M. Prentice, Natasha B. Leighl, Lesley Seymour, Hongbo Lui, Barbara Melosky, Anthony Reiman, Naveen S. Basappa, Glenwood D. Goss
Publikováno v:
Lung cancer (Amsterdam, Netherlands). 133
Introduction Activation of the RAS/RAF/MEK/ERK pathway may confer resistance to chemotherapy in non-small cell lung cancer (NSCLC). Selumetinib (AZD6244, ARRY142886), a MEK1/2 inhibitor combined with chemotherapy in patients with NSCLC was evaluated
Autor:
Scott M. Weissman, Martha Quezado, Katia Nones, Manuel A. R. Ferreira, Florian Grimpen, Sue Healey, Kelly Hamman, Samantha Hansford, Kasmintan A. Schrader, Anne Marie Patch, Itzhak Avital, Daniel L. Worthley, Pardeep Kaurah, Robertson MacKenzie, Juliet D. French, Evangelos Bellos, Jun Li, Kevin P. Rioux, George Chong, Georgia Chenevix-Trench, Leonard Da Silva, Kathleen A. Calzone, Graeme Suthers, Deborah W. Neklason, Andrew D. Clouston, Hilary C. Martin, Paul S. Meltzer, Jone E. Sampson, Kerry Phillips, Oliver F. Bathe, Theo Heller, Nicola K. Poplawski, Stacey L. Edwards, Peter T. Simpson, Alireza Heravi-Moussavi, David G. Huntsman, Janine Senz, Mark Bettington, Jonathan Beesley, Nicci Wayte, Tamsin R M Lannagan, Xiaoqing Chen, Wendy S. Rubinstein, Lyn Schofield, David E. Goldgar, Christopher Koh, Noralane M. Lindor, Lachlan J. M. Coin, Marie Jeanjean, Joshua J. Waterfall, Pavel N. Pichurin, Amanda B. Spurdle, Sylviane Olschwang, John V. Pearson, Udo Rudloff, Fátima Carneiro, Nicola Waddell, Sunil R. Lakhani, Rita A. Busuttil, Susan L. Woods, Anna Newlin, Haran Sivakumaran, Natasha Di Costanzo, Aurélie Fabre, Xiaogang Wen, Geoffrey J. Faulkner, Jason Sang Hun Lee, Robert L. Walker, Cathy Kiraly-Borri, Peter J. Hulick, Marbin Pineda, Sean Davis, Alex Boussioutas, William D. Foulkes, Jacqueline Armstrong
Publikováno v:
American Journal of Human Genetics
American Journal of Human Genetics, Elsevier (Cell Press), 2016, 98 (5), pp.830-842. ⟨10.1016/j.ajhg.2016.03.001⟩
American Journal of Human Genetics, 2016, 98 (5), pp.830-842. ⟨10.1016/j.ajhg.2016.03.001⟩
American Journal of Human Genetics, Elsevier (Cell Press), 2016, 98 (5), pp.830-842. ⟨10.1016/j.ajhg.2016.03.001⟩
American Journal of Human Genetics, 2016, 98 (5), pp.830-842. ⟨10.1016/j.ajhg.2016.03.001⟩
International audience; Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is an autosomal-dominant cancer-predisposition syndrome with a significant risk of gastric, but not colorectal, adenocarcinoma. We mapped the gene to 5q22 an