Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2)

Autor: Weston, C., Lu, J., Li, N., Barkan, K., Richards, G.O., Roberts, D.J., Skerry, T.M., Poyner, D., Pardamwar, M., Reynolds, C.A., Dowell, S.J., Willars, G.B., Ladds, G.

The glucagon and glucagon-like peptide-1 (GLP-1) receptors\ud play important, opposing roles in regulating blood glucose levels.\ud Consequently, these receptors have been identified as targets\ud for novel diabetes treatments. However, drugs acting

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Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2).

Autor: Weston C; From the Division of Biomedical Cell Biology, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom, caw38@leicester.ac.uk., Lu J; the Department of Cell Physiology and Pharmacology, University of Leicester, Leicester LE1 9HN, United Kingdom., Li N; the Department of Cell Physiology and Pharmacology, University of Leicester, Leicester LE1 9HN, United Kingdom., Barkan K; From the Division of Biomedical Cell Biology, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom., Richards GO; the Mellanby Centre for Bone Research, Department of Human Metabolism, University of Sheffield, Sheffield S10 2RX, United Kingdom., Roberts DJ; the Mellanby Centre for Bone Research, Department of Human Metabolism, University of Sheffield, Sheffield S10 2RX, United Kingdom., Skerry TM; the Mellanby Centre for Bone Research, Department of Human Metabolism, University of Sheffield, Sheffield S10 2RX, United Kingdom., Poyner D; the School of Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, United Kingdom., Pardamwar M; the School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, United Kingdom, and., Reynolds CA; the School of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, United Kingdom, and., Dowell SJ; the Department of Biological Sciences, Molecular Discovery Research, GlaxoSmithKline, Hertfordshire SG1 2NY, United Kingdom, and., Willars GB; the Department of Cell Physiology and Pharmacology, University of Leicester, Leicester LE1 9HN, United Kingdom., Ladds G; From the Division of Biomedical Cell Biology, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom, the Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom grl30@cam.ac.uk.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2015 Sep 18; Vol. 290 (38), pp. 23009-22. Date of Electronic Publication: 2015 Jul 21.