Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors.

Autor: Zhuo X; a Departments of Pharmaceutical Candidate Optimisation , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA and., Wang YZ; a Departments of Pharmaceutical Candidate Optimisation , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA and., Yeung KS; b Discovery Chemistry and Molecular Technologies , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA., Zhu J; b Discovery Chemistry and Molecular Technologies , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA., Huang XS; a Departments of Pharmaceutical Candidate Optimisation , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA and., Parcella KE; b Discovery Chemistry and Molecular Technologies , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA., Eastman KJ; b Discovery Chemistry and Molecular Technologies , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA., Kadow JF; b Discovery Chemistry and Molecular Technologies , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA., Meanwell NA; b Discovery Chemistry and Molecular Technologies , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA., Shu YZ; a Departments of Pharmaceutical Candidate Optimisation , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA and., Johnson BM; a Departments of Pharmaceutical Candidate Optimisation , Bristol-Myers Squibb Research and Development , Wallingford , CT , USA and.

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2018 Dec; Vol. 48 (12), pp. 1215-1226. Date of Electronic Publication: 2017 Dec 12.

Rotten to the core: antivirals targeting the HIV-1 capsid core.

Autor: McFadden, William M.¹ (AUTHOR), Snyder, Alexa A.¹ (AUTHOR), Kirby, Karen A.^1,2 (AUTHOR), Tedbury, Philip R.^1,2 (AUTHOR), Raj, Monika³ (AUTHOR), Wang, Zhengqiang⁴ (AUTHOR), Sarafianos, Stefan G.^1,2 (AUTHOR) stefanos.sarafianos@emory.edu

Publikováno v: Retrovirology. 12/22/2021, Vol. 18 Issue 1, p1-24. 24p.

Design, synthesis and biological evaluation of isoxazole-containing biphenyl derivatives as small-molecule inhibitors targeting the programmed cell death-1/ programmed cell death-ligand 1 immune checkpoint.

Autor: Zhu, Peiyu, Zhang, Jian, Yang, Yifei, Wang, Lixun, Zhou, Jinpei, Zhang, Huibin

Publikováno v: Molecular Diversity; Feb2022, Vol. 26 Issue 1, p245-264, 20p

HCV: The Journey From Discovery to a Cure : Volume I

Autor: Michael J. Sofia

Hepatitis C is a liver disease caused by the hepatitis C virus (HCV) and infects approximately 75 million individuals worldwide. It is also one of the major causes of liver cancer and liver transplants. The elucidation of the HCV genome, and the deve