Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Parastoo, Khoshakhlagh"'
Autor:
Songlei Liu, Johannes Striebel, Giovanni Pasquini, Alex H. M. Ng, Parastoo Khoshakhlagh, George M. Church, Volker Busskamp
Publikováno v:
Frontiers in Genome Editing, Vol 3 (2021)
Gene activation with the CRISPR-Cas system has great implications in studying gene function, controlling cellular behavior, and modulating disease progression. In this review, we survey recent studies on targeted gene activation and multiplexed scree
Externí odkaz:
https://doaj.org/article/75507b52e26a4dcd9d24a861e8555c2a
Publikováno v:
Transcription Factor Regulatory Networks ISBN: 9781071628140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5702651f0d6b7a46be36ccfd28cbe04f
https://doi.org/10.1007/978-1-0716-2815-7_10
https://doi.org/10.1007/978-1-0716-2815-7_10
Autor:
Emal, Lesha, Haydy, George, Mark M, Zaki, Cory J, Smith, Parastoo, Khoshakhlagh, Alex H M, Ng
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2594
Transcription factors (TFs) play a cardinal role in the development and maintenance of human physiology by acting as mediators of gene expression and cell state control. Recent advancements have broadened our knowledge on the potency of TFs in govern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c0e5e26293d6dc51c795e4dedcccc44b
https://pubmed.ncbi.nlm.nih.gov/36264493
https://pubmed.ncbi.nlm.nih.gov/36264493
Autor:
Insoo Hyun, J. C. Scharf-Deering, Sarah Sullivan, John Dennis Aach, Paola Arlotta, Matthew L. Baum, George M. Church, Aaron Goldenberg, Henry T. Greely, Parastoo Khoshakhlagh, Richie E. Kohman, Melissa Lopes, Caroline Lowenthal, Aric Lu, Alex H. M. Ng, Sergiu P. Pasca, Bruna Paulsen, Martina Pigoni, Christopher T. Scott, David A. Silbersweig, Mark A. Skylar-Scott, Robert D. Truog, Jeantine E. Lunshof
Publikováno v:
Nature neuroscience. 25(11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e67dda2b4581f76d55ceacc32c37e1
https://pubmed.ncbi.nlm.nih.gov/36258039
https://pubmed.ncbi.nlm.nih.gov/36258039
Autor:
Matthew Dysart, Kathleen Leeper, Marc Vidal, Richie E. Kohman, Seth L. Shipman, Jussi Taipale, Juan M. Melero-Martin, Andyna Vernet, Wren Saylor, Giovanni Pasquini, Kiavash Kiaee, Parastoo Khoshakhlagh, Jesus Eduardo Rojo Arias, Anka Swiersy, George M. Church, Alex Hay-Man Ng, Jeremy Y. Huang, Kai Wang, Volker Busskamp, Evan Appleton, Amanda R. Graveline, David E. Hill
Publikováno v:
Nature Biotechnology
Nature biotechnology
Nature biotechnology
Human pluripotent stem cells (hPSCs) offer an unprecedented opportunity to model diverse cell types and tissues. To enable systematic exploration of the programming landscape mediated by transcription factors (TFs), we present the Human TFome, a comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697cc503c11d7a469f2ea36f2735595d
https://doi.org/10.1038/s41587-020-0742-6
https://doi.org/10.1038/s41587-020-0742-6
Autor:
Raphael Ferreira, Marc Güell, Chun-Ting Wu, Khaled Said, Parastoo Khoshakhlagh, Verena Volf, Hannu Myllykallio, Cory Smith, Shilpa Garg, Amanda Hornick, Alex Hay-Man Ng, George M. Church, Oscar Castanon
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2020, 48 (9), pp.5183-5195. ⟨10.1093/nar/gkaa239⟩
Nucleic Acids Research, Oxford University Press, 2020, 48 (9), pp.5183-5195. ⟨10.1093/nar/gkaa239⟩
To extend the frontier of genome editing and enable editing of repetitive elements of mammalian genomes, we made use of a set of dead-Cas9 base editor (dBE) variants that allow editing at tens of thousands of loci per cell by overcoming the cell deat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e77ef9f3f0ffe80d86beea2eb800763
http://europepmc.org/articles/PMC7229841
http://europepmc.org/articles/PMC7229841
Autor:
Haydy George, Parastoo Khoshakhlagh, Songlei Liu, Kiavash Kiaee, Lindsey R. Robinson-McCarthy, Emal Lesha, Khaled Said, Angy Hanna, Evan Appleton, George M. Church, Mark M. Zaki, Alex Hay-Man Ng
Publikováno v:
Science Advances
Cell therapy has strong promise for treating COVID-19 survivors due to customizability, targetability, and regenerative function.
Coronavirus disease 2019 (COVID-19) continues to burden society worldwide. Despite most patients having a mild cour
Coronavirus disease 2019 (COVID-19) continues to burden society worldwide. Despite most patients having a mild cour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be33a41a6d98e46ac345f14da9cebff
http://europepmc.org/articles/PMC8357240
http://europepmc.org/articles/PMC8357240
Autor:
Hannu Myllykallio, Dysart M, David B. Thompson, Cory Smith, Raphael Ferreira, Khaled Said, George M. Church, Parastoo Khoshakhlagh, Oscar Castanon, Suming Wang, Yildiz R, Marc Güell
We have exploited the repetitive nature of transposable elements of the human genome to generate synthetic circuits. Transposable elements such as LINE-1 and Alu have successfully replicated in mammalian genomes throughout evolution to reach a copy n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e2b4878623650bd1636b7858df42e4
https://doi.org/10.1101/2020.02.03.922146
https://doi.org/10.1101/2020.02.03.922146
Autor:
Gita Kiaee, Nikolaos Dimitrakakis, Shabnam Sharifzadeh, Han‐Jun Kim, Reginald K. Avery, Kamyar Mollozadeh Moghaddam, Reihaneh Haghniaz, Ezgi Pinar Yalcintas, Natan Roberto de Barros, Solmaz Karamikamkar, Alberto Libanori, Ali Khademhosseini, Parastoo Khoshakhlagh
Publikováno v:
Adv Healthc Mater
Laponite is a clay-based material composed of synthetic disc-shaped crystalline nanoparticles with a large and highly ionic surface area. These characteristics enable the intercalation and dissolution of biomolecules in Laponite-based drug delivery s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9454566f44208153a51eea29df008c4a
https://doi.org/10.1002/adhm.202102054
https://doi.org/10.1002/adhm.202102054
Publikováno v:
Journal of Biomedical Materials Research Part A. 107:134-144
Photopolymerization provides a favorable method for hydrogel formation due to its simplicity, convenience, and versatility. However, the light exposure required to initiate photopolymerization is known to have a cytotoxic effect on encapsulated cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0d6521809c06b018d49088e20e3b022
https://doi.org/10.1002/jbm.a.36540
https://doi.org/10.1002/jbm.a.36540