Non-toxic polymer nanovectors for improved delivery of dexamethasone

Autor: Benjamin C. Ede, Paraskevi Diamanti, David S. Williams, Allison Blair

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)

Abstract Dexamethasone (Dex) is a highly insoluble front-line drug used in cancer therapy. Data from clinical trials indicates that the pharmacokinetics of Dex vary considerably between patients and prolonging drug exposure rather than increasing abs

Externí odkaz: https://doaj.org/article/7b565fee84e34ae2a46e1d888530d47a

Investigating CD99 Expression in Leukemia Propagating Cells in Childhood T Cell Acute Lymphoblastic Leukemia.

Autor: Charlotte V Cox, Paraskevi Diamanti, John P Moppett, Allison Blair

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0165210 (2016)

A significant number of children with T-lineage acute lymphoblastic leukemia (T-ALL) fail to respond to therapy and experience early relapse. CD99 has been shown to be overexpressed on T-ALL cells and is considered to be a reliable detector of the di

Externí odkaz: https://doaj.org/article/838653f55ba043deb6a280d3daecea67

Investigating the response of paediatric leukaemia‐propagating cells to BCL‐2 inhibitors

Autor: Phoebe E I Dace, John Moppett, Benjamin C Ede, Paraskevi Diamanti, William J Barendt, Jeremy Hancock, Allison Blair, Charlotte V. Cox

Publikováno v: British Journal of Haematology
Diamanti, P, Ede, B C, Dace, P E I, J Barendt, W, Cox, C V, Hancock, J P, Moppett, J P & Blair, A 2020, ' Investigating the response of paediatric leukaemia propagating cells to BCL-2 inhibitors ', British Journal of Haematology . https://doi.org/10.1111/bjh.16773

Summary Relapse of paediatric acute lymphoblastic leukaemia (ALL) may occur due to persistence of resistant cells with leukaemia‐propagating ability (LPC). In leukaemia, the balance of B‐cell lymphoma‐2 (BCL‐2) family proteins is disrupted, p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df603d96477f17007fc49d8700d4d976
https://doi.org/10.1111/bjh.16773

Investigating chemoresistance to improve sensitivity of childhood T-cell acute lymphoblastic leukemia to parthenolide

Autor: Paraskevi Diamanti, John Moppett, Rafal R Asmaro, Benjamin C Ede, Allison Blair

Publikováno v: Ede, B C, Asmaro, R R, Moppett, J P, Diamanti, P & Blair, A 2018, ' Investigating chemoresistance to improve sensitivity of childhood T-cell acute lymphoblastic leukemia to parthenolide ', Haematologica, vol. 103, no. 9, pp. 1493-1501 . https://doi.org/10.3324/haematol.2017.186700
Haematologica

Current therapies for childhood T-cell acute lymphoblastic leukemia have increased survival rates to above 85% in developed C countries. Unfortunately, some patients fail to respond to therapy and many suffer from serious side effects, highlighting t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644d1425600052e9475a1a93d9022bf6
https://doi.org/10.3324/haematol.2017.186700

Biodegradable, drug-loaded nanovectors via direct hydration as a new platform for cancer therapeutics

Autor: Benjamin C Ede, David S. Williams, Roxane Ridolfo, Jan C. M. van Hest, Paraskevi Diamanti, Adam W. Perriman, Allison Blair, Paul B. White

Publikováno v: Small, 14(32):1703774. Wiley-VCH Verlag
Small, 14, 1-10
Small, 14, 32, pp. 1-10
Small
Ridolfo, R, Ede, B C, Diamanti, P, White, P B, Perriman, A W, van Hest, J C M, Blair, A & Williams, D S 2018, ' Biodegradable, Drug-Loaded Nanovectors via Direct Hydration as a New Platform for Cancer Therapeutics ', Small, vol. 14, no. 32, 1703774 . https://doi.org/10.1002/smll.201703774

The stabilization and transport of low-solubility drugs, by encapsulation in nanoscopic delivery vectors (nanovectors), is a key paradigm in nanomedicine. However, the problems of carrier toxicity, specificity, and producibility create a bottleneck i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1022c261ce0b1e5bd257aef3163f7b
https://research.tue.nl/en/publications/af3054f4-7aa1-4ffb-8ae9-fef07c8c3538