Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Parashar Thapa"'
Autor:
Phuong T Nguyen, Hai M Nguyen, Karen M Wagner, Robert G Stewart, Vikrant Singh, Parashar Thapa, Yi-Je Chen, Mark W Lillya, Anh Tuan Ton, Richard Kondo, Andre Ghetti, Michael W Pennington, Bruce Hammock, Theanne N Griffith, Jon T Sack, Heike Wulff, Vladimir Yarov-Yarovoy
Publikováno v:
eLife, Vol 11 (2022)
The voltage-gated sodium NaV1.7 channel plays a key role as a mediator of action potential propagation in C-fiber nociceptors and is an established molecular target for pain therapy. ProTx-II is a potent and moderately selective peptide toxin from ta
Externí odkaz:
https://doaj.org/article/61a7e4bc52cf45b98b9c1e6f378c835a
Autor:
Michael J. Espiritu, Jonathan K. Taylor, Christopher K. Sugai, Parashar Thapa, Nikolaus M. Loening, Emma Gusman, Zenaida G. Baoanan, Michael H. Baumann, Jon-Paul Bingham
Publikováno v:
Marine Drugs, Vol 21, Iss 2, p 61 (2023)
χ-Conotoxins are known for their ability to selectively inhibit norepinephrine transporters, an ability that makes them potential leads for treating various neurological disorders, including neuropathic pain. PnID, a peptide isolated from the venom
Externí odkaz:
https://doaj.org/article/ae427a0baa8a42f0ad484d5d02a4dc23
Publikováno v:
Molecules, Vol 19, Iss 9, Pp 14461-14483 (2014)
The use of chemical ligation within the realm of peptide chemistry has opened various opportunities to expand the applications of peptides/proteins in biological sciences. Expansion and refinement of ligation chemistry has made it possible for the en
Externí odkaz:
https://doaj.org/article/6c433a61b49e4765bf2d5be4fdac83fa
Autor:
Hai M Nguyen, Phuong T Nguyen, Karen M Wagner, Robert G Stewart, Vikrant Singh, Parashar Thapa, Yi-Je Chen, Mark W Lillya, Anh Tuan Ton, Richard Kondo, Andre Ghetti, Michael W Pennington, Bruce Hammock, Theanne N Griffith, Jon T Sack, Heike Wulff, Vladimir Yarov-Yarovoy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33893d32f016b01de0ad9310c1b61a77
https://doi.org/10.7554/elife.81727.sa2
https://doi.org/10.7554/elife.81727.sa2
Autor:
Hai M Nguyen, Phuong T Nguyen, Karen M Wagner, Robert G Stewart, Vikrant Singh, Parashar Thapa, Yi-Je Chen, Mark W Lillya, Anh Tuan Ton, Richard Kondo, Andre Ghetti, Michael W Pennington, Bruce Hammock, Theanne N Griffith, Jon T Sack, Heike Wulff, Vladimir Yarov-Yarovoy
The voltage-gated sodium NaV1.7 channel plays a key role as a mediator of action potential propagation in C-fiber nociceptors and is an established molecular target for pain therapy. ProTx-II is a potent and moderately selective peptide toxin from ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0988b85ef375b455a45538fdc58e6c47
https://escholarship.org/uc/item/35r029z1
https://escholarship.org/uc/item/35r029z1
Autor:
Phuong T. Nguyen, Hai M. Nguyen, Karen M. Wagner, Robert G. Stewart, Vikrant Singh, Parashar Thapa, Yi-Je Chen, Mark W. Lillya, Anh Tuan Ton, Richard Kondo, Andre Ghetti, Michael W. Pennington, Bruce Hammock, Theanne N. Griffith, Jon T. Sack, Heike Wulff, Vladimir Yarov-Yarovoy
The voltage-gated sodium NaV1.7 channel plays a key role as a mediator of action potential propagation in C-fiber nociceptors and is an established molecular target for pain therapy. ProTx-II is a potent and moderately selective peptide toxin from ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2d947d4b583c02645779462fd248962
https://doi.org/10.1101/2022.07.21.500925
https://doi.org/10.1101/2022.07.21.500925
Autor:
Phuong T. Nguyen, Hai M. Nguyen, Karen M. Wagner, Robert Stewart, Vikrant Singh, Parashar Thapa, Anh Tuan Ton, Richard P. Kondo, Andre Ghetti, Michael W. Pennington, Bruce Hammock, Theanne N. Griffith, Jon T. Sack, Heike Wulff, Vladimir Yarov-Yarovoy
Publikováno v:
Biophysical Journal. 122:309a
Autor:
Parashar Thapa, Jon T. Sack, Sebastian Fletcher-Taylor, Rayan Kaakati, Bruce E. Cohen, Vladimir Yarov-Yarovoy, Rebecka J. Sepela
Publikováno v:
ACS Chem Neurosci
Ion channels are polymorphic membrane proteins whose high-resolution structures offer images of individual conformations, giving us starting points for identifying the complex and transient allosteric changes that give rise to channel physiology. Her
Autor:
Bruce E. Cohen, Parashar Thapa, Sebastian Fletcher-Taylor, Oscar Vivas, Rebecka J. Sepela, Robert Stewart, Mark Lillya, Laxmi Kumar Parajuli, Jon T. Sack, Karen Zito
Publikováno v:
Journal of General Physiology. 153
A primary goal of molecular physiology is to understand how conformational changes of proteins affect the function of cells, tissues, and organisms. Here, we describe an imaging method for measuring the conformational changes of the voltage sensors o
Autor:
Zhong Wang, Rebecka J. Sepela, L.A. Valencia, Bruce E. Cohen, Robert Stewart, Parashar Thapa, Jon T. Sack
Publikováno v:
Biophysical journal, vol 121, iss 8
Kv2 voltage-gated potassium channels are modulated by AMIGO neuronal adhesion proteins. Here, we identify steps in the conductance activation pathway of Kv2.1 channels that are modulated by AMIGO1 using voltage clamp recordings and spectroscopy of he