Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Parashar, Dhapola"'
Concurrent stem- and lineage-affiliated chromatin programs precede hematopoietic lineage restriction
Autor:
Fatemeh Safi, Parashar Dhapola, Sarah Warsi, Mikael Sommarin, Eva Erlandsson, Jonas Ungerbäck, Rebecca Warfvinge, Ewa Sitnicka, David Bryder, Charlotta Böiers, Ram Krishna Thakur, Göran Karlsson
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113357- (2023)
Externí odkaz:
https://doaj.org/article/afa99b9a000946b79b1053681bd6ceed
Autor:
Parashar Dhapola, Johan Rodhe, Rasmus Olofzon, Thomas Bonald, Eva Erlandsson, Shamit Soneji, Göran Karlsson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
As the scale of single-cell genomics experiments grows into the millions, the computational requirements to process this data are beyond the reach of many. Here the authors present Scarf, a modularly designed Python package that makes the analysis wo
Externí odkaz:
https://doaj.org/article/60f7efb619a7412992aebe738a7a79f6
Autor:
Anna Konturek-Ciesla, Parashar Dhapola, Qinyu Zhang, Petter Säwén, Haixia Wan, Göran Karlsson, David Bryder
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112304- (2023)
Summary: Aging negatively affects hematopoiesis, with consequences for immunity and acquired blood cell disorders. Although impairments in hematopoietic stem cell (HSC) function contribute to this, the in vivo dynamics of such changes remain obscure.
Externí odkaz:
https://doaj.org/article/16e2103f62f84a6d9818638bcd2db14c
In vitro clonal multilineage differentiation of distinct murine hematopoietic progenitor populations
Autor:
Fatemeh Safi, Parashar Dhapola, Eva Erlandsson, Linda Geironson Ulfsson, Ariana S. Calderón, Charlotta Böiers, Göran Karlsson
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101965- (2023)
Summary: Here we describe an in vitro co-culture system that can differentiate hematopoietic progenitor populations to all major hematopoietic lineages at clonal level. We present both a sensitive single-cell switch-culture system as well as a less l
Externí odkaz:
https://doaj.org/article/5c57f55d5800494682503c01d97127a2
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103251- (2021)
Summary: Single-cell RNAseq is a routinely used method to explore heterogeneity within cell populations. Data from these experiments are often visualized using dimension reduction methods such as UMAP and tSNE, where each cell is projected in two or
Externí odkaz:
https://doaj.org/article/7d70ed2f0d934eb0a567f32c61290641
Autor:
Vikas Sood, Kiran Bala Sharma, Vishal Gupta, Dhurjhoti Saha, Parashar Dhapola, Manish Sharma, Utsav Sen, Shigetaka Kitajima, Shantanu Chowdhury, Manjula Kalia, Sudhanshu Vrati
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract Stringent regulation of antiviral signaling and cellular autophagy is critical for the host response to virus infection. However, little is known how these cellular processes are regulated in the absence of type I interferon signaling. Here,
Externí odkaz:
https://doaj.org/article/8ce5b5bafe084c7b89b6e768a4e4585a
Autor:
Ivan Imaz-Rosshandler, Christina Rode, Carolina Guibentif, Mai-Linh N. Ton, Parashar Dhapola, Daniel Keitley, Ricard Argelaguet, Fernando J. Calero-Nieto, Jennifer Nichols, John C. Marioni, Marella F.T.R. de Bruijn, Berthold Göttgens
Early organogenesis represents a key step in animal development, where pluripotent cells divide and diversify to initiate formation of all major organs. Here, we used scRNA-Seq to profile over 300,000 single cell transcriptomes sampled in 6 hour inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13426d6f027c88d04c7b99495d72f71e
https://doi.org/10.1101/2023.03.17.532833
https://doi.org/10.1101/2023.03.17.532833
Autor:
Mikael N.E. Sommarin, Rasmus Olofzon, Sara Palo, Parashar Dhapola, Göran Karlsson, Charlotta Böiers
Knowledge of human fetal blood development and how it differs from adult is highly relevant for our understanding of congenital blood and immune disorders as well as childhood leukemia, the latter known to originate in utero. Blood production during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::849fce65876de3f6c26cb96ed2bf43e7
https://doi.org/10.1101/2021.12.29.474425
https://doi.org/10.1101/2021.12.29.474425
Autor:
Parashar Dhapola, Johan Rodhe, Rasmus Olofzon, Thomas Bonald, Eva Erlandsson, Shamit Soneji, Göran Karlsson
Publikováno v:
Nature communications. 13(1)
As the scale of single-cell genomics experiments grows into the millions, the computational requirements to process this data are beyond the reach of many. Herein we present Scarf, a modularly designed Python package that seamlessly interoperates wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da504ed086c1a3a29848c1efb6f71a2c
https://pubmed.ncbi.nlm.nih.gov/35941103
https://pubmed.ncbi.nlm.nih.gov/35941103
Autor:
Aitzkoa Lopez de Lapuente Portilla, Ludvig Ekdahl, Caterina Cafaro, Zain Ali, Natsumi Miharada, Gudmar Thorleifsson, Kristijonas Žemaitis, Antton Lamarca Arrizabalaga, Malte Thodberg, Maroulio Pertesi, Parashar Dhapola, Erik Bao, Abhishek Niroula, Divya Bali, Gudmundur Norddahl, Nerea Ugidos Damboriena, Vijay G. Sankaran, Göran Karlsson, Unnur Thorsteinsdottir, Jonas Larsson, Kari Stefansson, Björn Nilsson
Publikováno v:
Blood
Stem cell transplantation is a cornerstone in the treatment of blood malignancies. The most common method to harvest stem cells for transplantation is by leukapheresis, requiring mobilization of CD34+ hematopoietic stem and progenitor cells (HSPCs) f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc1d0847b219cdf35ef623c434b9506
https://pubmed.ncbi.nlm.nih.gov/35007327
https://pubmed.ncbi.nlm.nih.gov/35007327