Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Paras K. Mishra"'
Autor:
Flobater I. Gawargi, Paras K. Mishra
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Diabetes significantly increases the risk of heart failure by inducing myocardial cell death, potentially through ferroptosis—an iron-dependent, non-apoptotic cell death pathway characterized by lipid peroxidation. The role of cardiac ferr
Externí odkaz:
https://doaj.org/article/ce11763d178e46c6839442b4f0383a73
Autor:
Flobater I. Gawargi, Paras K. Mishra
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110622- (2024)
Summary: Ferroptosis, defined by the suppression of glutathione peroxidase-4 (GPX4) and iron overload, is a distinctive form of regulated cell death. Our in-depth research identifies matrix metalloproteinase-9 (MMP9) as a critical modulator of ferrop
Externí odkaz:
https://doaj.org/article/5c895be2a7304870a4379c4266374b8e
Autor:
Santosh K. Yadav, Flobater I. Gawargi, Mohammad H. Hasan, Ritesh Tandon, Jason W. Upton, Paras K. Mishra
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract Cytomegalovirus (CMV) is a widely prevalent herpesvirus that reaches seroprevalence rates of up to 95% in several parts of the world. The majority of CMV infections are asymptomatic, albeit they have severe detrimental effects on immunocompr
Externí odkaz:
https://doaj.org/article/4c062d611b2e4c5fa9061e4a297584b7
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1392 (2022)
Metabolic remodeling is at the heart of diabetic cardiomyopathy. High glycemic fluctuations increase metabolic stress in the type 1 diabetes mellitus (T1DM) heart. There is a lack of understanding on how metabolites and genes affect metabolic remodel
Externí odkaz:
https://doaj.org/article/85ac45907d034da1a6898f03cb2f3bf2
Autor:
Sumit Kar, Hamid R. Shahshahan, Tyler N. Kambis, Santosh K. Yadav, Zhen Li, David J. Lefer, Paras K. Mishra
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Patients with diabetes, a methionine-rich meat diet, or certain genetic polymorphisms show elevated levels of homocysteine (Hcy), which is strongly associated with the development of cardiovascular disease including diabetic cardiomyopathy. However,
Externí odkaz:
https://doaj.org/article/17f419b775c04e558bde13f3fff08142
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 6 (2019)
Advanced diabetes mellitus (DM) may have both insulin resistance and deficiency (double DM) that accelerates diabetic cardiomyopathy (DMCM), a cardiac muscle disorder. Reduced cardiac miR-133a, a cardioprotective miRNA, is associated with DMCM. Howev
Externí odkaz:
https://doaj.org/article/ee0acdde5b674898925c3c8f79caa51e
Autor:
Mediha Becirovic-Agic, Upendra Chalise, Michael J. Daseke, Shelby Konfrst, Jeffrey D. Salomon, Paras K. Mishra, Merry L. Lindsey
Publikováno v:
Biomolecules, Vol 11, Iss 4, p 491 (2021)
Over the past three decades, numerous studies have shown a strong connection between matrix metalloproteinase 9 (MMP-9) levels and myocardial infarction (MI) mortality and left ventricle remodeling and dysfunction. Despite this fact, clinical trials
Externí odkaz:
https://doaj.org/article/6cb2619efe74410691ba9e7273f342c7
Autor:
Paras K. Mishra, Sushil K. Mahata, Wei Ying, Shyam Sundar Nandi, Gautam K. Bandyopadhyay, Kaushik K. Patel
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
The heart possesses a remarkable inherent capability to adapt itself to a wide array of genetic and extrinsic factors to maintain contractile function. Failure to sustain its compensatory responses results in cardiac dysfunction, leading to cardiomyo
Externí odkaz:
https://doaj.org/article/2520a18f6f764af38e595c00ed0204a4
Autor:
Paras K. MISHRA, Bashisth N. SINGH
Publikováno v:
European Journal of Entomology, Vol 103, Iss 4, Pp 805-815 (2006)
Understanding the genetic mechanisms of morphological evolution is one of the greatest challenges in evolutionary biology and for such studies sexually dimorphic traits in closely related species are of prime interest. In the Drosophila bipectinata s
Externí odkaz:
https://doaj.org/article/74f13a4593924044b2e79f0f25dca2b5
Autor:
Song-Young Park, Elizabeth J. Pekas, Cody P. Anderson, Tyler N. Kambis, Paras K. Mishra, Molly N. Schieber, TeSean K. Wooden, Jonathan R. Thompson, Kyung Soo Kim, Iraklis I. Pipinos
Publikováno v:
Am J Physiol Heart Circ Physiol
Peripheral artery disease (PAD) is an atherosclerotic disease that impairs blood flow and muscle function in the lower limbs. A skeletal muscle myopathy characterized by mitochondrial dysfunction and oxidative damage is present in PAD; however, the u